Chadderton, Paul - Imperial College London - Department of Bioengineering

个人简介

The brain is composed of billions of neurons that are intricately connected within small circuits. We are interested in the roles that these circuits play in sensory perception and behaviour. To do this, we record the electrical activity of single cells and small populations, combining advanced electrophysiology and molecular tools to record and manipulate neuronal activity in behaving animals. We are especially interested in how the circuits of neocortex and cerebellum combine information from the outside world (the senses) with internally generated signals (thoughts and intentions) to appropriately guide behaviour. Our goal is to understand how computation by neural circuits is applied in the representation of the external and internal world.

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Chen S, Augustine GJ, Chadderton P 2016. The cerebellum linearly encodes whisker position during voluntary movement. eLife 10509 Duguid I, Branco T, Chadderton P, Arlt C, Powell K, Häusser M 2015. Control of cerebellar granule cell output by sensory-evoked Golgi cell inhibition. PNAS 112: 13099-13104 Chadderton P, Schaefer AT, Williams SR, Margrie TW 2014. Sensory-evoked synaptic integration in cerebellar and cerebral cortical neurons, Nature Rev Neurosci 15: 71-83. Duguid I, Branco T, London M, Chadderton P, Häusser M 2012. Tonic inhibition enhances fidelity of sensory information transmission in the cerebellar cortex. J Neurosci 32: 11132-11143. Harris KD, Bartho P, Chadderton P, Curto C, de la Rocha J, Hollender L, Itskov V, Luczak A, Marguet SL, Renart A, Sakata S 2011. How do neurons work together? Lessons from auditory cortex, Hearing Res 271: 37-53 Saleem AB, Chadderton P, Apergis-Schoute J, Harris KD, Schultz SR 2010. Methods for predicting cortical UP and DOWN states from the phase of deep layer local field potentials. J Comp Neurosci 29: 49-62 Chadderton P, Agapiou JP, McAlpine D, Margrie TW 2009. The synaptic representation of sound source location in auditory cortex. J Neurosci 29: 14127-14135 Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, Häusser M 2007. High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature 450: 1245-1248 Loewenstein Y, Mahon S, Chadderton P, Kitamura K, Sompolinsky H, Yarom Y, Häusser M 2005. Bistability of cerebellar Purkinje cells modulated by sensory stimulation. Nat Neurosci 8: 202-211 Chadderton P, Margrie TW, Häusser M, 2004. Integration of quanta in cerebellar granule cells during sensory processing. Nature 428: 856-860 Mittmann W, Chadderton P, Häusser M, 2004. Neuronal microcircuits: frequency-dependent flow of inhibition. Curr Biol 14: R837-R839