Boutelle, Martyn - Imperial College London - Department of Bioengineering

个人简介

Martyn Boutelle trained at Imperial College gaining a PhD in electrochemistry with John Albery FRS in the Department of Chemistry. He then moved to Physiology at the University of Oxford where he worked with Marianne Fillenz and Allen Hill FRS in the interdisciplinary area of in vivo monitoring of the brain using electrochemical sensors. His work there lead to an interest in brain metabolism, and monitoring extracellular neurochemistry with high time resolution by use of microelectrodes and on-line microdialysis. This was extended to clinical monitoring of the brain in 1995 when he moved to the Department of Chemistry, King’s College where he was a Lecturer then Reader in Biomedical Analysis. He joined Imperial College in December 2004. He now works closely with neurosurgeons at King’s College Hospital, bowel and kidney surgeons at Imperial College, and Maxillofacial surgeons at Queen Alexandra's Hospital Portsmouth on the use of on-line microdialysis to detect transient ischaemia, and the development of new clinical monitoring techniques. These techniques combine electrochemical biosensors in novel microfludic devices with other real-time measurements such as tissue oxygen, electrical activity, blood pressure and flow to give multimodal monitoring. He is a founder member of COSBID (www.cosbid.org), a grouping of clinicians and fundamental scientists interested in the role of spontaneous brain depolarisations in the maturation of brain injury.

研究领域

My biomedical monitoring research group is multidisciplinary, embracing both the development of fundamental physical/ analytical science methods and the use of these new techniques in a programme of neuroscience and clinical science research. My approach is to combine real-time measurement of neurochemical, electrical and physical measurements such as blood flow and local brain pressure to give a clear picture of the dynamics of tissue response to stimulation or trauma. The same measurement techniques are used in patients and in experimental models allowing genuine translational research.

近期论文

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Dreier JP, Fabricius M, Ayata C, Sakowitz OW, William Shuttleworth C, Dohmen C, Graf R, Vajkoczy P, Helbok R, Suzuki M, Schiefecker AJ, Major S, Winkler MK, Kang EJ, Milakara D, Oliveira-Ferreira AI, Reiffurth C, Revankar GS, Sugimoto K, Dengler NF, Hecht N, Foreman B, Feyen B, Kondziella D, Friberg CK, Piilgaard H, Rosenthal ES, Westover MB, Maslarova A, Santos E, Hertle D, Sánchez-Porras R, Jewell SL, Balança B, Platz J, Hinzman JM, Lückl J, Schoknecht K, Schöll M, Drenckhahn C, Feuerstein D, Eriksen N, Horst V, Bretz JS, Jahnke P, Scheel M, Bohner G, Rostrup E, Pakkenberg B, Heinemann U, Claassen J, Carlson AP, Kowoll CM, Lublinsky S, Chassidim Y, Shelef I, Friedman A, Brinker G, Reiner M, Kirov SA, Andrew RD, Farkas E, Güresir E, Vatter H, Chung LS, Brennan KC, Lieutaud T, Marinesco S, Maas AI, Sahuquillo J, Dahlem MA, Richter F, Herreras O, Boutelle MG, Okonkwo DO, Bullock MR, Witte OW, Martus P, van den Maagdenberg AM, Ferrari MD, Dijkhuizen RM, Shutter LA, Andaluz N, Schulte AP, MacVicar B, Watanabe T, Woitzik J, Lauritzen M, Strong AJ, Hartings JAet al., 2016, Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group., J Cereb Blood Flow Metab Hamaoui K, Gowers S, Boutelle M, Cook T, Hanna G, Darzi A, Smith R, Dorling A, Papalois Vet al., 2016, Organ Pretreatment with Cytotopic Endothelial Localising Peptides To Ameliorate Microvascular Thrombosis & Perfusion Deficits In Ex-vivo Renal Haemo-reperfusion Models., Transplantation Hamaoui K, Gowers S, Damji S, Rogers M, Leong CL, Hanna G, Darzi A, Boutelle M, Papalois Vet al., 2016, Rapid sampling microdialysis as a novel tool for parenchyma assessment during static cold storage and hypothermic machine perfusion in a translational ex vivo porcine kidney model, JOURNAL OF SURGICAL RESEARCH, Vol: 200, Pages: 332-345, ISSN: 0022-4804 Hartings JA, Shuttleworth CW, Kirov SA, Ayata C, Hinzman JM, Foreman B, Andrew RD, Boutelle MG, Brennan KC, Carlson AP, Dahlem MA, Drenckhahn C, Dohmen C, Fabricius M, Farkas E, Feuerstein D, Graf R, Helbok R, Lauritzen M, Major S, Oliveira-Ferreira AI, Richter F, Rosenthal ES, Sakowitz OW, Sánchez-Porras R, Santos E, Schöll M, Strong AJ, Urbach A, Westover MB, Winkler MK, Witte OW, Woitzik J, Dreier JPet al., 2016, The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão's legacy., J Cereb Blood Flow Metab Moser N, Leong CL, Hu Y, Boutelle M, Georgiou Pet al., 2016, An ion imaging ISFET array for Potassium and Sodium detection, Pages: 2847-2850, ISSN: 0271-4310 Papadimitriou KI, Wang C, Rogers ML, Gowers SAN, Leong CL, Boutelle MG, Drakakis EMet al., 2016, High-Performance Bioinstrumentation for Real-Time Neuroelectrochemical Traumatic Brain Injury Monitoring, FRONTIERS IN HUMAN NEUROSCIENCE, Vol: 10, ISSN: 1662-5161 Phairatana T, Leong CL, Gowers SA, Patel BA, Boutelle MGet al., 2016, Real-time detection of carboplatin using a microfluidic system., Analyst, Vol: 141, Pages: 6270-6277 Rogers ML, Leong CL, Gowers SA, Samper IC, Jewell SL, Khan A, McCarthy L, Pahl C, Tolias CM, Walsh DC, Strong AJ, Boutelle MGet al., 2016, Simultaneous monitoring of potassium, glucose and lactate during spreading depolarisation in the injured human brain - Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis., J Cereb Blood Flow Metab Sharma S, Huang Z, Rogers M, Boutelle M, Cass AEet al., 2016, Evaluation of a minimally invasive glucose biosensor for continuous tissue monitoring., Anal Bioanal Chem Fotopoulou C, Gorgy T, Paterson A, Petkos K, Cunnea P, Wu W, Drakakis E, Gabra H, Boutelle Met al., 2015, Molecular physiology monitoring of ovarian cancer ex vivo., Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X Gowers SAN, Curto VF, Seneci CA, Wang C, Anastasova S, Vadgama P, Yang G-Z, Boutelle MGet al., 2015, 3D Printed Microfluidic Device with Integrated Biosensors for Online Analysis of Subcutaneous Human Microdialysate, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 7763-7770, ISSN: 0003-2700 Hutchinson PJ, Jalloh I, Helmy A, Carpenter KL, Rostami E, Bellander BM, Boutelle MG, Chen JW, Claassen J, Dahyot-Fizelier C, Enblad P, Gallagher CN, Helbok R, Hillered L, Le Roux PD, Magnoni S, Mangat HS, Menon DK, Nordström CH, O'Phelan KH, Oddo M, Perez Barcena J, Robertson C, Ronne-Engström E, Sahuquillo J, Smith M, Stocchetti N, Belli A, Carpenter TA, Coles JP, Czosnyka M, Dizdar N, Goodman JC, Gupta AK, Nielsen TH, Marklund N, Montcriol A, O'Connell MT, Poca MA, Sarrafzadeh A, Shannon RJ, Skjøth-Rasmussen J, Smielewski P, Stover JF, Timofeev I, Vespa P, Zavala E, Ungerstedt Uet al., 2015, Consensus statement from the 2014 International Microdialysis Forum., Intensive Care Med, Vol: 41, Pages: 1517-1528 Lawrance D, Williamson C, Boutelle MG, Cass AEGet al., 2015, Development of a disposable bile acid biosensor for use in the management of cholestasis, ANALYTICAL METHODS, Vol: 7, Pages: 3714-3719, ISSN: 1759-9660 Wu W, Vitharana K, Gorgy T, Paterson A, Cunnea P, Gabra H, Fotopoulou C, Boutelle MG, Drakakis EMet al., 2015, A Method for Voltage Measurements of Cancerous vs Non-cancerous Omentum, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 7514-7517, ISSN: 1557-170X Gorgy T, Paterson A, Vitharana K, Wu W, Drakakis M, Gabra H, Boutelle M, Fotopoulou Cet al., 2014, MOLECULAR PHYSIOLOGY MONITORING OF OVARIAN CANCER EX VIVO, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 24, Pages: 402-402, ISSN: 1048-891X Jeffcote T, Hinzman JM, Jewell SL, Learney RM, Pahl C, Tolias C, Walsh DC, Hocker S, Zakrzewska A, Fabricius ME, Strong AJ, Hartings JA, Boutelle MGet al., 2014, Detection of Spreading Depolarization with Intraparenchymal Electrodes in the Injured Human Brain, NEUROCRITICAL CARE, Vol: 20, Pages: 21-31, ISSN: 1541-6933 Jeffcote T, Jewell S, Pahl C, Tolias C, Walsh D, Strong A, Mulcahy S, Boutelle Met al., 2014, INTRAPARENCHYMAL ELECTRODE RECORDINGS OF CORTICAL SPREADING DEPOLARISATION AND CONTINUOUS SEIZURE ACTIVITY - NEUROVASCULAR DISRUPTION AND SEIZURE OXYGEN THRESHOLDS, 11th Symposium of the International-Neurotrauma-Society, Publisher: MARY ANN LIEBERT, INC, Pages: A51-A51, ISSN: 0897-7151 Kothur RR, Hall J, Patel BA, Leong CL, Boutelle MG, Cragg PJet al., 2014, A low pH sensor from an esterified pillar[5]arene, CHEMICAL COMMUNICATIONS, Vol: 50, Pages: 852-854, ISSN: 1359-7345 Boutelle MG, Rogers ML, Leong CL, Feuerstein D, Graff Ret al., 2013, The dynamics of glucose and lactate metabolism in the injured brain during spreading depolarisation, 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American-Society-for-Neurochemistry, Publisher: WILEY-BLACKWELL, Pages: 48-48, ISSN: 0022-3042 Hamaoui K, Aftab A, Gowers S, Mastoridis S, Rudd D, Boutelle M, Darzi A, Dobson G, Papalois Vet al., 2013, A NOVEL ADENOSINE/LIDOCAINE PRESERVATION SOLUTION FOR RENAL MACHINE PERFUSION - A POTENTIAL ALTERNATIVE TO UNIVERSITY OF WISCONSIN SOLUTION?, TRANSPLANT INTERNATIONAL, Vol: 26, Pages: 336-336, ISSN: 0934-0874