个人简介
Dr Olajide received his Ph.D. in Pharmacology from the University of Ibadan in Nigeria where he investigated anti-inflammatory properties of natural products. He was a Humboldt Postdoctoral Research Fellow at the Center for Drug Research (Pharmaceutical Biology), Department of Pharmacy, University of Munich, Germany where he studied cellular and molecular pharmacology of anti-inflammatory natural products, focusing on Nuclear Factor-kappa B (NF-κB) signalling. Part of his postdoctoral work was carried out in the Neurochemistry Research Laboratory, Department of Psychiatry, University of Freiburg Medical School where he conducted research on cellular and molecular pharmacology of anti-neuroinflammatory natural products.
Dr Olajide started his academic career as a Lecturer in Pharmacology in the Faculty of Pharmacy, Obafemi Awolowo University, Nigeria. He later moved to the College of Medicine, University of Ibadan, Nigeria as a Lecturer in Pharmacology. Dr Olajide had a brief stint in industry where he was involved in drug development and clinical research; he helped in developing new drugs for type 2 diabetes and atopic dermatitis. Prior to moving to Huddersfield, he was Senior Lecturer in Pharmaceutical Sciences at London Metropolitan University. Dr Olajide is on the editorial board of Evidence Based Complementary and Alternative Medicine (eCAM).
研究领域
Nuclear Factor-kappa B (NF-κB) Signalling in the Activated Microglia
Microglial NF-κB signalling pathway is critical to neuroinflammation as it is responsible for the transcriptional regulation of genes which contribute to damage and death of adjacent neurons in neurodegenerative disorders such as Alzheimer’s disease. Targeting NF-κB signalling in neuroinflammation is therefore an important strategy in identifying novel small molecules for delaying the onset and/or progression of diseases like AD. Research in my group investigates natural and novel synthetic compounds which inhibit neuroinflammation by targeting NF-κB and associated pathways involving the mitogen activated protein kinases (MAPKs) and PI3K/Akt.
Neuroprotection by Natural and Synthetic Steroids
Menopause is associated with sharp declines in the levels of circulating oestrogens. This hormonal change has been linked to impairment in brain functions relevant to dementia and cognitive aging. An accumulation of evidence suggests that oestrogens are neuroprotective. However, there are significant cancer risks associated with these hormones. Consequently, a promising translational tool could be the development of selective oestrogen receptor modulators (SERMs). In collaboration with medicinal chemists, we are currently employing structure-activity relationships to synthesise, optimise and investigate novel neuroprotective SERMs with much lower risks of cancer.
AMPK and Nrf2 Signalling in Neuroinflammation
Adenosine monophosphate-activated protein kinase (AMPK) is a critical sensor of cellular energy balance. However, new evidence shows that this kinase exhibits neuroprotective potentials. AMPK activation has been shown to cause marked inhibition on lipopolysaccharide (LPS)-mediated neuroinflammation in the microglia. Consequently, pharmacological activation of AMPK could be an important strategy in blocking the detrimental effects of neuroinflammation on neurons. The nuclear factor E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) antioxidant cytoprotective mechanism has been linked to AMPK signalling. Activation of Nrf2/HO-1 has also been shown to inhibit NF-κB, and ultimately neuroinflammation. Using pharmacological antagonists and RNA interference (RNAi), we are investigating the roles of AMPK/Nrf2 in anti-neuroinflammatory activity of selected compounds.
Neuroinflammation in Cerebral Malaria (CM)
Malaria is a wide spread infectious disease that is responsible for 2-3 million deaths annually. The most severe neurological complication of acute Plasmodium falciparum malaria is cerebral malaria (CM). In CM, the formation of a metabolic waste, hemozoin (HZ) has been shown to induce inflammation and morphological changes in microvascular endothelium, leading to an increase in blood brain barrier (BBB) permeability, neuroinflammation and neurological sequelae in survivors. Consequently, adjunctive therapies which target neuroinflammation are needed. We are currently investigating the impact of HZ on multiple signalling pathways in the microglia. We expect that this research will identify novel targets for discovering new drugs for adjunctive treatment of CM.
近期论文
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Onasanwo, S., Velagapudi, R., El-Bakoush, A. and Olajide, O. (2016) ‘Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism’ Molecular and Cellular Biochemistry , 414 (1), pp. 23-36. ISSN 0300-8177
Okorji, U., Velagapudi, R., El-Bakoush, A., Fiebich, B. and Olajide, O. (2015) ‘Antimalarial drug artemether inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms’ Molecular Neurobiology , pp. 1-18. ISSN 1559-1182
Olajide, O., Velagapudi, R., Kumar, A., Schindler, S. and Fiebich, B. (2015) ‘Thymoquinone inhibits inflammation in IL-1?-stimulated SK-N-SH cells’ Inflammation Research , 64 (2), pp. 51-248. ISSN 1023-3830
Velagapudi, R., Baco, G., Khela, S., Okorji, U. and Olajide, O. (2015) ‘Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1? stimulated SK-N-SH cells’ European Journal of Nutrition . ISSN 1436-6207
Velagapudi, R., Aderogba, M. and Olajide, O. (2014) ‘Tiliroside, a dietary glycosidic flavonoid inhibits TRAF-6/NF-kB/p38-mediated neuroinflammation in activated BV2 microglia’ Biochimica et Biophysica Acta (BBA) - General Subjects , 1840 (12), pp. 3311-3319. ISSN 03044165
Okorji, U. and Olajide, O. (2014) ‘A semi-synthetic derivative of artemisinin, artesunate inhibits prostaglandin E2 production in LPS/IFN?-activated BV2 microglia’ Bioorganic and Medicinal Chemistry , 22 (17), pp. 4726-4734. ISSN 0968-0896
Olajide, O., Kumar, A., Velagapudi, R., Okorji, U. and Fiebich, B. (2014) ‘Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia’ Molecular Nutrition and Food Research , 58 (9), pp. 1843-1851. ISSN 1613-4133
Olajide, O., Velagapudi, R., Okorji, U., Sarker, S. and Fiebich, B. (2014) ‘Picralima nitida seeds suppress PGE2 production by interfering with multiple signalling pathways in IL 1?-stimulated SK-N-SH neuronal cells’ Journal of ethnopharmacology , 152 (2), pp. 377-383. ISSN 0378-8741
Olajide, O. and Wright, C. (2014) ‘Cryptolepine induced apoptosis in TNFalpha-stimulated A549 lung carcinoma cells through NF-kappaB signalling pathway’ pA2 Online . ISSN 1741-1149
Velagapudi, R., Olajide, O. and Aderogba, M. (2014) ‘Tiliroside Produced Anti-Neuroinflammatory Effects Through Interference With NF-?B And MAPK Signalling In LPS+ IFN-? Stimulated BV-2 Microglia.’ pA2 Online . ISSN 1741-1149
Okorji, U. and Olajide, O. (2014) ‘Artesunate inhibits prostaglandin E2 (PGE2) production in LPS + IFN-? activated BV-2 microglia cells’ pA2 Online , 11 (3). ISSN 1741-1157
Olajide, O. and Fiebich, B. (2013) ‘Traditional African Medicine as a source of biologically active substances inhibiting neuroinflammation’ Planta Medica , 79 (13), p. 1112. ISSN 0032-0943
Olajide, O., Bhatia, H., de Oliveira, A., Wright, C. and Fiebich, B. (2013) ‘Inhibition of neuroinflammation in LPS-activated microglia by cryptolepine’ Evidence-Based Complementary and Alternative Medicine , 2013, pp. 1-10. ISSN 1741-427X
Olajide, O., Bhatia, H., Oliveira, A., Wright, C. and Fiebich, B. (2013) ‘Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-kappaB and p38 MAPK inhibition’ European Journal of Medicinal Chemistry , 63, pp. 333-339. ISSN 0223-5234
Olajide, O., Aderogba, M. and Fiebich, B. (2013) ‘Mechanisms of Anti-inflammatory Property of Anacardium occidentale Stem Bark: Inhibition of NF-kappaB and MAPK Signaling in the Microglia’ Journal of ethnopharmacology , 145 (1), pp. 42-49. ISSN 0378-8741
Olajide, O. and Fiebich, B. (2013) ‘Pomegranate suppresses PGE2 production and COX- 2 expression in IL-1?-stimulated SK-N-SH neuronal cells: implications for Alzheimer’s disease.’ Planta Medica , 79, p. 1266. ISSN 0032-0943
Olajide, O., Aderogba, M., Okorji, U. and Fiebich, B. (2012) ‘Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling’ Evidence-Based Complementary and Alternative Medicine , 2012, pp. 1-8. ISSN 1741-427X
Olajide, O (2012) ‘Anti-neuroinflammatory and Anti-amyloidogenic Properties of Punicalagin in LPS-Activated Rat Primary Microglia’. In: BPS Winter Meeting, 18th - 20th December 2012, London, UK
Olajide, O., Pinheiro de Oliveira, A., Unekwe, J., Wright, C. and Fiebich, B. (2010) ‘Cryptolepis sanguinolenta (Lindl.) Schltr. root extract inhibits prostaglandin production in IL-1b stimulated SK-N-SH neuronal cells’ Planta Medica , 76 (12), p. 601. ISSN 0032-0943
Olajide, O., Ajayi, A. and Wright, C. (2009) ‘Anti-inflammatory properties of cryptolepine.’ Phytotherapy research , 23 (10), pp. 1421-1425. ISSN 1099-1573
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