Morral, Jordi - Huddersfield University

个人简介

I graduated with a First Class degree in Pharmacy (MPharm) from the University of Barcelona in 1993 and I was awarded the Degree Extraordinary Award. I decided to stay at the University of Barcelona to carry out a PhD in Organic and Medicinal Chemistry (Synthesis of tacrine-huperzine A hybrids and huperzine A analogues, with potential utility in the treatment of Alzheimer’s disease) under the co-supervision of Prof Camps and Dr Muñoz-Torrero (1999). After my PhD I gained five years’ postdoctoral experience at: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium (2000) with Prof. Herdewijn. Cyclohexene nucleosides as new potent antiviral compounds and antisense oligonucleotides. Laboratory of Medicinal Chemistry, University of Antwerp, Belgium (2001) with Prof. Augustyns and Dr. Wigerinck, Dept. of Medicinal Chemistry and Drug Discovery, Tibotec, Mechelen, Belgium. Bio-affinity resins as absorption model for drug candidates. Chemistry Department at the University of Manchester (2002-2004) with now Prof Micklefield. Exploring the high affinity, kinetically selective binding of RNA over DNA by pyrrolidine-amide oligonucleotide mimics (POM). After an unexpected change of career working for a while as a Pharmacy Manager for Lloydspharmacy, I am now working as part-time lecturer ((“Drug Synthesis, Metabolism and Analysis” and “Drug Design and Development I”) at the University of Huddersfield. I am an Honorary Research Fellow at the Institute of Cancer Therapeutics, University of Bradford, and work as a part-time pharmacist for Cohens Chemist.

研究领域

My experience is in the areas of Organic and Medicinal Chemistry and Chemical Biology. I have published widely in these areas and I am co-author of 15 refereed journal articles and one International Patent.

近期论文

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Morral-Cardoner, J (2014) ‘Linking a Pharmaceutical Chemistry Workshop to Pharmacy Practice’ Scientia Pharmaceutica , 83 (1), pp. 125-142. ISSN 0036-8709 Tan, T., Worthington, R., Pritchard, R., Morral-Cardoner, J. and Micklefield, J. (2007) ‘Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties’ Organic & Biomolecular Chemistry , 5 (2), pp. 239-248. ISSN 14770520 Worthington, R., O'Rourke, A., Morral-Cardoner, J., Tan, T. and Micklefield, J. (2007) ‘Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties’ Organic & Biomolecular Chemistry , 5 (2), pp. 249-259. ISSN 14770520 Tan, T., Hickman, D., Morral-Cardoner, J., Beadham, I. and Micklefield, J. (2004) ‘Nucleic acid binding properties of thyminyl and adeninyl pyrrolidine-amide oligonucleotide mimics (POM)’ Chemical Communications (5), pp. 516-517. ISSN 1359-7345 Gu, P., Morral-Cardoner, J., Wang, J., Rozenski, J., Busson, R., Van Aerschot, A., De Clercq, E. and Herdewijn, P. (2003) ‘Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides’ Nucleosides, Nucleotides & Nucleic Acids , 22 (5), pp. 845-847. ISSN 1525-7770 Hickman, D., Tan, T., Morral-Cardoner, J., King, P., Cooper, M. and Micklefield, J. (2003) ‘Design, synthesis, conformational analysis and nucleic acid hybridisation properties of thymidyl pyrrolidine-amide oligonucleotide mimics (POM)’ Organic & Biomolecular Chemistry , 1 (19), pp. 3277-3292. ISSN 14770520 Gu, P., Morral-Cardoner, J., Wang, J., Rozenski, J., Busson, R., Van Aerschot, A., De Clercq, E. and Herdewijn, P. (2003) ‘Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides’ Antivral Chemistry and Chemotherapy , 14 (1), pp. 31-37. ISSN 0956-3202 Wang, J., Morral-Cardoner, J., Hendrix, C. and Herdewijn, P. (2001) ‘A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine’ The Journal of Organic Chemistry , 66 (25), pp. 8478-8482. ISSN 00223263 Camps, P., El Achab, R., Morral-Cardoner, J., Muñoz-Torrero, D., Badia, A., Baños, J., Vivas, N., Barril, X., Orozco, M. and Luque, F. (2000) ‘New Tacrine?Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease’ Journal of Medicinal Chemistry , 43 (24), pp. 4657-4666. ISSN 0022-2623 Camps, P., Contreras, J., El Achab, R., Morral-Cardoner, J., Muñoz-Torrero, D., Font-Bardia, M., Solans, X., Badia, A. and Vivas, N. (2000) ‘New Syntheses of rac-Huperzine A and its rac-7-Ethyl-Derivative. Evaluation of Several Huperzine A Analogues as Acetylcholinesterase Inhibitors’ Tetrahedron , 56 (26), pp. 4541-4553. ISSN 0040-4020 Camps, P., Cusack, B., Mallender, W., El Achab, R., Morral-Cardoner, J., Muñoz-Torrero, D. and Rosenberry, T. (2000) ‘Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease’ Molecular Pharmacology , 57 (2), pp. 409-417. ISSN 0026-895X Camps Garcia, P., Muñoz-Torrero, D., Gorbig, D., Contreras, J., Simon, M., Morral-Cardoner, J., El Achab, R., Badia, A., Baños, J. and Vivas, N.(1999) Polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use. 5,965,569. Camps, P., El Achab, R., Görbig, D., Morral-Cardoner, J., Muñoz-Torrero, D., Badia, A., Baños, J., Vivas, N., Barril, X., Orozco, M. and Luque, F. (1999) ‘Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine?Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease’ Journal of Medicinal Chemistry , 42 (17), pp. 3227-3242. ISSN 0022-2623 Camps, P., Contreras, J., Morral-Cardoner, J., Muñoz-Torrero, D., Font-Bardia, M. and Solans, X. (1999) ‘Synthesis of an 11-unsubstituted analogue of (±)-huperzine A’ Tetrahedron , 55 (28), pp. 8481-8496. ISSN 0040-4020 Camps, P., Contreras, J., Font-Bardia, M., Morral-Cardoner, J., Muñoz-Torrero, D. and Solans, X. (1998) ‘Enantioselective synthesis of tacrine–huperzine A hybrids. Preparative chiral MPLC separation of their racemic mixtures and absolute configuration assignments by X-ray diffraction analysis’ Tetrahedron: Asymmetry , 9 (5), pp. 835-849. ISSN 09574166 Camps, P., Morral-Cardoner, J. and Muñoz-Torrero, D. (1998) ‘On the synthesis of 2-Amino-4,6-difluorobenzonitrile: Highly Selective Formation of 5-Fluoro-3-nitro-1,2-benzoquinone 2-diazide in the Attempted Sandmeyer Cyanation of 2,4-Difluoro-6-nitrobenzenediazonium cation’ Journal of chemical research , pp. 144-145. ISSN 1747-5198 Camps, P., Elachab, R., Font-bardia, M., Gorbig, D., Morral-Cardoner, J., Munoz-torrero, D., Solans, X. and Simon, M. (1996) ‘Easy synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones by silica gel-promoted fragmentation of 3-alkyl-2-oxaadamant-1-yl mesylates’ Tetrahedron , 52 (16), pp. 5867-5880. ISSN 0040-4020