Merchant, Hamid - Huddersfield University

个人简介

Dr Hamid Merchant is a Senior Lecturer in Pharmaceutics at the University of Huddersfield. He has a formulation sciences background with extensive experience both from industry and academia. He has a particular interest in drug delivery research at the interface of gastroenterology and publishes regularly in peer-reviewed journals. He is an overseas qualified and registered pharmacist. His clinical knowledge and expertise in pharmaceutics helps students to understand the clinical and therapeutic principles underpinning the science of dosage form design. Before joining Huddersfield in November 2013, he was a postdoctoral fellow at the University College London (UCL), where he investigated various technologies for drug delivery into gastrointestinal tract and offered technical support and expert advice to collaborators and clients from academia and industry on various formulation and drug delivery aspects. One of his postdoc assignments at UCL was to develop a novel formulation for colonic delivery of statins for an emerging pharmaceutical company in UK. During his time at UCL (Nov 2007 to Nov 2012), he has also developed novel in-vitro solutions for assessment of pharmaceutical and neutraceutial products in physiologically relevant conditions. He developed innovative strategies for exploiting physiological bicarbonate buffers for dissolution testing and devised an Auto pH SystemTM – a robust instrumentation and dynamic dissolution media (PCT/GB2013/051145) employing physiological bicarbonate buffers simulating the aboral changes in gastrointestinal pH while dosage form transits down the gut. Hamid has also won a proof of concept fund from UCL Business to further the technology. He was associated with Abbott Laboratories Ltd from December 2002 to November 2007 and served in various capacities such as quality, formulation, new product development, continuous improvement and project management. He is involved in peer review of various research journals and is a member of American Association of Pharmaceutical Scientists (AAPS), Controlled Release Society (CRS) and Academy of Pharmaceutical Sciences, Great Britain (APS). Hamid graduated with a BPharm from the University of Karachi (Pakistan) in 2002 and became a registered pharmacist (RPh) with the Pharmacy Council of Sindh in 2003. He started his career with Pharma Professional Services in May 2002, the then small emerging consultancy company in Pakistan and soon acceded to a dynamic role in Abbott Laboratories. During his time at Abbott, he also completed his MPharm (part-time) in Pharmaceutical Formulations in September 2005 and also completed a PGD in Quality Management from NED University of Engineering and Technology and became a Certified Quality Professional (CQP) by the Institute of Quality Control in 2006. Hamid served at Abbott until Nov 2007 when he received a prestigious scholarship by The Aga Khan Foundation (AKF) to pursue his doctoral research with Prof Abdul Basit at The School of Pharmacy (UCL), where he was also awarded an esteemed Overseas Research Scholarship (ORS) by the British Government and completed his PhD in November 2011.

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Merchant, H., Liu, F., Orlu Gul, M. and Basit, A. (2016) ‘Age-mediated changes in the gastrointestinal tract’ International Journal of Pharmaceutics . ISSN 0378-5173 Hatton, G., Yadav, V., Basit, A. and Merchant, H. (2015) ‘Animal Farm: Considerations in Animal Gastrointestinal Physiology and Relevance to Drug Delivery in Humans’ Journal of Pharmaceutical Sciences , 104 (9), pp. 2747-2776. ISSN 0022-3549 Merchant, H., Afonso-Pereira, F., Rabbie, S., Youssef, S. and Basit, A. (2015) ‘Gastrointestinal characterisation and drug solubility determination in animals’ Journal of Pharmacy and Pharmacology , 67 (5), pp. 630-639. ISSN 0022-3573 Goyanes, A., Hatton, G., Merchant, H. and Basit, A. (2015) ‘Gastrointestinal release behaviour of modified-release drug products: Dynamic dissolution testing of mesalazine formulations’ International Journal of Pharmaceutics , 484 (1-2), pp. 103-108. ISSN 03785173 Merchant, H., Goyanes, A., Parashar, N. and Basit, A. (2014) ‘Predicting the gastrointestinal behaviour of modified-release products: Utility of a novel dynamic dissolution test apparatus involving the use of bicarbonate buffers’ International Journal of Pharmaceutics , 475 (1-2), pp. 585-591. ISSN 0378-5173 Merchant, H., Rabbie, S., Varum, F., Afonso-Pereira, F. and Basit, A. (2014) ‘Influence of ageing on the gastrointestinal environment of the rat and its implications for drug delivery.’ European Journal of Pharmaceutical Sciences , 62, pp. 76-85. ISSN 0928-0987 Varum, F., Merchant, H., Goyanes, A., Zboranová, V. and Basit, A. (2014) ‘Accelerating the dissolution of enteric coatings in the upper small intestine: Evolution of a novel pH 5.6 bicarbonate buffer system to assess drug release.’ International Journal of Pharmaceutics , 468 (1-2), pp. 172-177. ISSN 03785173 Kaassis, A., Young, N., Sano, N., Merchant, H., Yu, D., Chatterton, N. and Williams, G. (2014) ‘Pulsatile drug release from electrospun poly(ethylene oxide)–sodium alginate blend nanofibres’ Journal of Materials Chemistry B (10), pp. 1400-14078. ISSN 2050-750X Yadav, V., Gaisford, S., Merchant, H. and Basit, A. (2013) ‘Colonic bacterial metabolism of corticosteroids.’ International Journal of Pharmaceutics , 457 (1), pp. 268-274. ISSN 03785173 Merchant, H., Frost, J. and Basit, A.(2013) Apparatus and methods for testing medicaments. PCT/GB2013/051145. Araujo, V., Gamboa, A., Caro, N., Abugoch, L., Gotteland, M., Valenzuela, F., Merchant, H., Basit, A. and Tapia, C. (2013) ‘Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery.’ Journal of Pharmaceutical Sciences , 102 (8), pp. 2748-2759. ISSN 0022-3549 Araujo, V., Gamboa, A., Caro, N., Abugoch, L., Gotteland, M., Valenzuela, F., Merchant, H., Basit, A. and Tapia, C. (2013) ‘Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery.’ Journal of Pharmaceutical Sciences , 102 (8), pp. 2748-2759. ISSN 0022-3549 Freire, A., Basit, A., Choudhary, R., Piong, C. and Merchant, H. (2011) ‘Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery.’ International Journal of Pharmaceutics , 415 (1-2), pp. 15-28. ISSN 0378-5173 Freire, A., Basit, A., Choudhary, R., Piong, C. and Merchant, H. (2011) ‘Does sex matter? The influence of gender on gastrointestinal physiology and drug delivery.’ International Journal of Pharmaceutics , 415 (1-2), pp. 15-28. ISSN 03785173 Liu, F., Merchant, H., Kulkarni, R., Alkademi, M. and Basit, A. (2011) ‘Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products.’ European Journal of Pharmaceutics and Biopharmaceutics , 78 (1), pp. 151-157. ISSN 0939-6411 Liu, F., Merchant, H., Kulkarni, R., Alkademi, M. and Basit, A. (2011) ‘Evolution of a physiological pH 6.8 bicarbonate buffer system: application to the dissolution testing of enteric coated products.’ European Journal of Pharmaceutics and Biopharmaceutics , 78 (1), pp. 151-157. ISSN 0939-6411 Merchant, H., McConnell, E., Liu, F., Ramaswamy, C., Kulkarni, R., Basit, A. and Murdan, S. (2011) ‘Assessment of gastrointestinal pH, fluid and lymphoid tissue in the guinea pig, rabbit and pig, and implications for their use in drug development.’ European Journal of Pharmaceutical Sciences , 42 (1-2), pp. 3-10. ISSN 0928-0987 Varum, F., Merchant, H. and Basit, A. (2010) ‘Oral modified-release formulations in motion: the relationship between gastrointestinal transit and drug absorption.’ International Journal of Pharmaceutics , 395 (1-2), pp. 26-36. ISSN 03785173 Fadda, H., Merchant, H., Arafat, B. and Basit, A. (2009) ‘Physiological bicarbonate buffers: stabilisation and use as dissolution media for modified release systems.’ International Journal of Pharmaceutics , 382 (1-2), pp. 56-60. ISSN 03785173 Merchant, H., Shoaib, H., Tazeen, J. and Yousuf, R. (2006) ‘Once-daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: a technical note.’ AAPS PharmSciTech , 7 (3), p. E178-E183. ISSN 1530-9932