Conway, Barbara - Huddersfield University

个人简介

Barbara is Head of Pharmacy at the University of Huddersfield. She was appointed as Professor of Pharmaceutics at the University of Huddersfield in 2010. Following her first degree in Pharmacy at Queen’s University, Belfast, she registered as a pharmacist in 1990 and practised full-time in community pharmacy until joining Aston University in Birmingham in 1992 to undertake a Ph.D. Her PhD research project at Aston was in the pharmaceutics and drug delivery field, focusing on microencapsulation for delivery of biopharmaceuticals. Following completion of her PhD studies in 1995, she was employed in various posts at Aston University, including lecturer and senior lecturer and was Director of the M.Pharm. programme prior to moving to the University of Huddersfield in 2010 as Professor of Pharmaceutics. During this time, she also became a Fellow of the Higher Education Academy and supervised projects on the application of e-learning technologies in Pharmacy. She was also a Medici Fellow, specialising in driving forward innovation within the university sector and hold several patents in the pharmaceutical area. She has supervised over 20 Ph.D. students and on-going research programmes focus on chrontherapeutic delivery and delivery of antimicrobials, novel excipients for drug delivery, the mechanical properties of pharmaceuticals and excipients and the development of chewing gum delivery systems. She has a number of successful collaborations with other universities, NHS and pharmaceutical industry leading to publications and development of new products.

研究领域

Her research encompasses the improvement of traditional and development of novel drug formulations in relation to stability, bioavailability and patient compliance. A major barrier to introduction of new chemical entities onto the market as novel therapeutics is the design of efficient delivery systems for drugs that are poorly soluble, unstable, or are of low permeability. Research in the group focuses on application of pharmaceutics, with the aim of improving delivery of challenging molecules through biological membranes and barriers with particular emphasis on rational formulation design and the introduction of innovation. Understanding the fundamental physical properties of delivery systems in relation to their performance is key and one research strand focuses on the characterising the relationship between solid state properties and the performance of pharmaceutical materials, for example the prediction of mechanical properties of salt forms of drugs based on their crystal structures with a view to improving processing. Other research strands involve the development of formulations for oral, ophthalmic and transdermal drug delivery, the design of modified release systems, including the use of mucoadhesives, fast-dissolving and chewing gum formulations and the enhancement of solubility and dissolution for poorly soluble drugs. It is essential to address both physiological and physiochemical barriers to drug absorption with a view to developing improved formulation strategies in clinical practice, for example, effective delivery of antiseptics into the lower layers of the skin to improve asepsis.

近期论文

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Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions’ Colloids and Surfaces B: Biointerfaces , 146, pp. 841-851. ISSN 0927-7765 Mohammad, M., Grimsey, I., Forbes, R., Blagbrough, I. and Conway, B. (2016) ‘Effect of mechanical denaturation on surface free energy of protein powders’ Colloids and Surfaces B: Biointerfaces , 146, pp. 700-706. ISSN 0927-7765 Adebisi, A., Kaialy, W., Hussain, T., Al-Hamidi, H., Nokhodchi, A., Conway, B. and Asare-Addo, K. (2016) ‘An assessment of triboelectrification effects on co-ground solid dispersions of carbamazepine’ Powder Technology , 292, pp. 342-350. ISSN 00325910 Nep, E., Asare-Addo, K., Ghori, M., Conway, B. and Smith, A. (2015) ‘Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour’ International Journal of Pharmaceutics , 496 (2), pp. 689-698. ISSN 03785173 Adebisi, A., Conway, B. and Asare-Addo, K. (2015) ‘The influence of fillers on theophylline release from clay matrices’ American Journal of Pharmacological Sciences , 3 (5), pp. 120-125. ISSN 2327-6711 Ghori, M., Mahdi, M., Smith, A. and Conway, B. (2015) ‘Nasal Drug Delivery Systems: An Overview’ American Journal of Pharmacological Sciences , 3 (5), pp. 110-119. ISSN 2327-6711 Casey, A., Karpanen, T., Nightingale, P., Conway, B. and Elliott, T. (2015) ‘Antimicrobial activity and skin permeation of iodine present in an iodine-impregnated surgical incise drape’ Journal of Antimicrobial Chemotherapy , 70 (8), pp. 2255-2260. ISSN 0305-7453 Mahdi, M., Conway, B. and Smith, A. (2015) ‘Development of mucoadhesive sprayable gellan gum fluid gels’ International Journal of Pharmaceutics , 488 (1-2), pp. 12-19. ISSN 0378-5173 Adebisi, A. and Conway, B. (2015) ‘Modification of drug delivery to improve antibiotic targeting to the stomach’ Therapeutic Delivery , 6 (6), pp. 741-762. ISSN 2041-5990 Ghori, M. and Conway, B. (2015) ‘Hydrophilic Matrices for Oral Control Drug Delivery’ American Journal of Pharmacological Sciences , 3 (5), pp. 103-109. ISSN 2327-6711 Asare-Addo, K., Šupuk, E., Al-Hamidi, H., Owusu-Ware, S., Nokhodchi, A. and Conway, B. (2015) ‘Triboelectrification and dissolution property enhancements of solid dispersions’ International Journal of Pharmaceutics , 485 (1/2), pp. 306-316. ISSN 03785173 Laity, P., Asare-Addo, K., Sweeney, F., Šupuk, E. and Conway, B. (2015) ‘Using small-angle X-ray scattering to investigate the compaction behaviour of a granulated clay’ Applied Clay Science , 108, pp. 149-164. ISSN 01691317 Adebisi, A., Laity, P. and Conway, B. (2015) ‘Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori’ Journal of Pharmacy and Pharmacology , 67 (4), pp. 511-524. ISSN 0022-3573 Ghori, M., Šupuk, E. and Conway, B. (2015) ‘Tribo-electrification and Powder Adhesion Studies in the Development of Polymeric Hydrophilic Drug Matrices’ Materials , 8 (4), pp. 1482-1498. ISSN 1996-1944 Kakadia, P. and Conway, B. (2015) ‘Lipid nanoparticles for dermal drug delivery’ Current Pharmaceutical Design , 21 (20), pp. 2823-2829. ISSN 1381-6128 Ghori, M., Šupuk, E. and Conway, B. (2014) ‘Tribo-electric Charging and Adhesion of Cellulose Ethers and their Mixtures with Flurbiprofen’ European Journal of Pharmaceutical Sciences , 65, pp. 1-8. ISSN 0928-0987 Ghori, M., Alba, K., Smith, A., Conway, B. and Kontogiorgos, V. (2014) ‘Okra Extracts In Pharmaceutical And Food Applications’ Food Hydrocolloids , 42 (3), pp. 342-347. ISSN 0268-005X Mahdi, M., Conway, B. and Smith, A. (2014) ‘Evaluation of gellan gum fluid gels as modified release oral liquids’ International Journal of Pharmaceutics , 475 (1-2), pp. 335-343. ISSN 0378-5173 Kakadia, P. and Conway, B. (2014) ‘Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery’ American Journal of Pharmacological Sciences , 2 (5A). Adebisi, A. and Conway, B. (2014) ‘Lectin-conjugated microspheres for eradication of Helicobacter pylori infection and interaction with mucus’ International Journal of Pharmaceutics , 470 (1-2), pp. 28-40. ISSN 0378-5173