Smith, Alan - Huddersfield University

个人简介

Dr Smith graduated from Salford University (Biochemical Science) in 1997 before gaining his PhD from Cranfield University developing polysaccharide substitutes for gelatin in the production of pharmaceutical capsules under the supervision of Prof. Ed Morris. Following his PhD Dr Smith worked for 2 years as a formulation scientist within the pharmaceutical industry before taking up a position as a polysaccharide chemist at Industrial Research Limited, Wellington, New Zealand. On his return to the UK Dr. Smith has worked as a post doctoral research fellow at the University of Birmingham (School of Dentistry) and Aston University (School of Pharmacy) developing 3D cell scaffolds and polysaccharide based drug delivery systems. In 2008 he joined the tissue regeneration and interface laboratory within Chemical Engineering at the University of Birmingham where he continued to develop his research on biopolymers for tissue engineering and drug delivery applications before being appointed as a Senior Lecturer in Pharmaceutics at the University of Huddersfield in March 2011.

研究领域

Dr Smith’s research group focuses on pharmaceutical and medical applications of biopolymers. Biopolymers are a versatile class of materials which exhibit easily tailorable properties that are advantageous in developing bio-responsive drug delivery systems and functional cell culture substrates. Cell Encapsulation and Delivery Polysaccharides hydrogels provide an extremely mild and simple route to 3D cell immobilisation providing the cells with an environment that is similar to natural extracellular matrix. Dr Smith is developing these hydrogels to enable the culture of multiple cell types from a population of mesenchymal stem cells, within a single 3D structure. He is also interested in how the mechanical properties of hydrogels change in physiological and cell culture conditions and how this impacts on the phenotype of encapsulated cells. In addition to this, he is also investigating how the extent of diffusion of molecules through different hydrogels effect tissue development. Bioadhesion and Physiologically Responsive Biopolymers The ability to retain a drug or cells at the site of action is an important consideration for many localised applications such as wound healing and ocular drug delivery. Biopolymers in particular, can interact with physiological secretions via physical interactions allowing sustained delivery of therapeutic molecules. Currently, Dr Smith is developing methods to measure sol- gel transitions in situ and investigating how modification of various biopolymers can enhance bioadhesion and increase drug retention time. Dosage form development Within this research theme Dr Smith is interested in developing modified release formulations for oral delivery by utilizing the physiological responsive nature of biopolymers. In particular, developing novel enteric pharmaceutical capsules (Patent No. WO/2008/119943) and enteric oral liquid formulations. Polysaccharide Extraction Characterisation and Application Dr Smith’s group are also interested in the fundamental chemical and physical properties polysaccharides extracted from plants native to sub Saharan Africa. Funded by Royal Society (Newton Fellowships) this theme is designed to address issues of people within developing countries that cannot afford modern medicines due to the high cost of expensive imported raw materials. Many of these counties however, have an abundance of natural resources from which materials can be extracted that provide an equivalent or even an improved function. By revealing the chemical and physical properties of these polysaccharides we hope to promote their use in pharmaceutical and biomedical applications.

近期论文

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Nep, E., Carnachan, S., Ngwuluka, N., Kontogiorgos, V., Morris, G., Sims, I. and Smith, A. (2016) ‘Structural characterisation and rheological properties of a polysaccharide from sesame leaves (Sesamum radiatum Schumach. & Thonn.)’ Carbohydrate Polymers , 152, pp. 541-547. ISSN 0144-8617 Abodinar, A., Tømmeraas, K., Ronander, E., Smith, A. and Morris, G. (2016) ‘The physicochemical characterisation of pepsin degraded pig gastric mucin’ International Journal of Biological Macromolecules , 87, pp. 281-286. ISSN 0141-8130 Smith, A., Moxon, S. and Morris, G. (2016) ‘Biopolymers as wound healing materials’. In: Wound Healing Biomaterials - Volume 2: Functional Biomaterials. : Woodhead Publishing: an imprint of Elsevier. pp. 261-287. ISBN 978-0-08-100606-1 Moxon, S. and Smith, A. (2016) ‘Controlling the rheology of gellan gum hydrogels in cell culture conditions’ International Journal of Biological Macromolecules , 84, pp. 79-86. ISSN 01418130 Nep, E., Sims, I., Kontogiorgos, V., Morris, G. and Smith, A. (2016) ‘Evaluation of some important physicochemical properties of starch free grewia gum’ Food Hydrocolloids , 53, pp. 134-140. ISSN 0268-005X Nep, E., Asare-Addo, K., Ghori, M., Conway, B. and Smith, A. (2015) ‘Starch-free grewia gum matrices: Compaction, swelling, erosion and drug release behaviour’ International Journal of Pharmaceutics , 496 (2), pp. 689-698. ISSN 03785173 Ghori, M., Mahdi, M., Smith, A. and Conway, B. (2015) ‘Nasal Drug Delivery Systems: An Overview’ American Journal of Pharmacological Sciences , 3 (5), pp. 110-119. ISSN 2327-6711 Kontogiorgos, V., Smith, A. and Morris, G. (2015) ‘The parallel lives of polysaccharides in food and pharmaceutical formulations’ Current Opinion in Food Science , 4, pp. 13-18. ISSN 2214-7993 Mahdi, M., Conway, B. and Smith, A. (2015) ‘Development of mucoadhesive sprayable gellan gum fluid gels’ International Journal of Pharmaceutics , 488 (1-2), pp. 12-19. ISSN 0378-5173 Diryak, R., Mahdi, M., Kontogiorgos, V., Morris, G. and Smith, A. (2015) ‘In situ rheological measurements of the external gelation of alginate’ Food Hydrocolloids , 55, pp. 77-80. ISSN 0268-005X Thompson, M., Hunt, B., Smith, A. and Joyce, T. (2015) ‘Wear Tests of a Potential Biolubricant for Orthopedic Biopolymers’ Lubricants , 3 (2), pp. 80-90. ISSN 2075-4442 Smith, A., Paxton, J., Hung, Y., Hadley, M., Bowen, J., Williams, R. and Grover, L. (2015) ‘Nanoscale crystallinity modulates cell proliferation on plasma sprayed surfaces’ Materials Science and Engineering: C , 48, pp. 5-10. ISSN 09284931 Ghori, M., Alba, K., Smith, A., Conway, B. and Kontogiorgos, V. (2014) ‘Okra Extracts In Pharmaceutical And Food Applications’ Food Hydrocolloids , 42 (3), pp. 342-347. ISSN 0268-005X Morris, G., Smith, A. and Kontogiorgos, V. (2014) ‘Editorial: Special Issue of Food Hydrocolloids: Bridging the Divide’ Food Hydrocolloids , 42 (3), p. 317. ISSN 0268-005X Mahdi, M., Conway, B. and Smith, A. (2014) ‘Evaluation of gellan gum fluid gels as modified release oral liquids’ International Journal of Pharmaceutics , 475 (1-2), pp. 335-343. ISSN 0378-5173 Abodinar, A., Smith, A. and Morris, G. (2014) ‘A novel method to estimate the stiffness of carbohydrate polyelectrolyte polymers based on the ionic strength dependence of zeta potential’ Carbohydrate Polymers , 112, pp. 6-9. ISSN 0144-8617 Ghori, M., Ginting, G., Smith, A. and Conway, B. (2014) ‘Simultaneous quantification of drug release and erosion from hypromellose hydrophilic matrices’ International Journal of Pharmaceutics , 465 (1-2), pp. 405-412. ISSN 0378-5173 Smith, A., Fleming, L., Wudebwe, U., Bowen, J. and Grover, L. (2014) ‘Development of a synovial fluid analogue with bio-relevant rheology for wear testing of orthopaedic implants’ Journal of the Mechanical Behavior of Biomedical Materials , 32, pp. 177-184. ISSN 17516161 Asare-Addo, K., Mahdi, M. and Smith, A. (2013) ‘Development of modified release paediatric liquids’. In: 5th EuPFI Conference, 18th-19th Spain 2013, Barcelona, Spain , pp. 31-32 Jamshidi, P., Ma, P., Khosrowyar, K., Smith, A. and Grover, L. (2012) ‘Tailoring gel modulus using dispersed nanocrystalline hydroxyapatite’ Journal of Experimental Nanoscience , 7 (6), pp. 652-661. ISSN 1745–8080