Haslam, Iain - Huddersfield University - Department of Biological Sciences

个人简介

My scientific career began with an undergraduate degree in Biomedical Sciences at the University of Aberdeen, after which I went on to complete my PhD research at the University of Newcastle. Under the guidance of Professor Nick Simmons in the Epithelial Research Group, I spent 3 years investigating the regulation of ATP binding cassette (ABC) transporters by the pregnane X receptor. This was followed by a Postdoctoral Fellowship with AstraZeneca, developing a modified Ussing chamber system to investigate cross-species intestinal absorption. Returning to academic research, I spent 4 years working with Professor Ralf Paus at the University of Manchester. Here I developed an interest in cutaneous biology, specifically investigating mechanisms for hair follicle defence against endogenous and exogenous stressors, including oxidative and xenobiotic. In 2015 I joined the University of Huddersfield as a Senior Lecturer in Biological Sciences where I continue research into my twin interests of skin biology and active transport processes.

研究领域

I am primarily interested in active transport processes, in particular energy-dependent efflux mediated by ABC transporters. Having spent a number of years investigating the impact of ABC transporters on drug-drug interactions and the intestinal absorption of drug molecules, more recently I have been examining their roles in the skin, specifically focusing on the hair follicle. I recently identified the expression of numerous ABC transporter proteins within the hair follicle and this has led on to current investigations into their ability to modulate hair follicle drug penetration, with a view to understanding their impact on drug toxicity and hair loss during chemotherapy. Furthermore, the physiological roles of the ABC transporter family are increasingly appreciated. To this end I am investigating whether ABC transporter activity in the hair follicle might influence the movement and compartmentalization of lipid signalling activities. Understanding the role of active transport in regulating hair growth, cycling and development could have important implications for a number hair growth disorders.

近期论文

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Hawkshaw, N., Haslam, I., Ansell, D., Shamalak, A. and Paus, R. (2015) ‘Re-Evaluating Cyclosporine A as a Hair Growth-Promoting Agent in Human Scalp Hair Follicles’ The Journal of Investigative Dermatology , 135 (8), pp. 2129-2132. ISSN 1523-1747 Purba, T., Haslam, I., Shahmalak, A., Bhogal, R. and Paus, R. (2015) ‘Mapping the expression of epithelial hair follicle stem cell-related transcription factors LHX2 and SOX9 in the human hair follicle’ Experimental dermatology , 24 (6), pp. 462-467. ISSN 1600-0625 Haslam, I., El-Chami, C., Faruqi, H., Shahmalak, A., O'Neill, C. and Paus, R. (2015) ‘Differential expression and functionality of ATP-binding cassette transporters in the human hair follicle’ The British Journal of Dermatology , 172 (6), pp. 1562-1572. ISSN 1365-2133 Hardman, J., Tobin, D., Haslam, I., Farjo, N., Farjo, B., Al-Nuaimi, Y., Grimaldi, B. and Paus, R. (2015) ‘The peripheral clock regulates human pigmentation’ The Journal of Investigative Dermatology , 135 (4), pp. 1053-1064. ISSN 1523-1747 Hardman, J., Haslam, I., Farjo, N., Farjo, B. and Paus, R. (2015) ‘Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle’ PLoS ONE , 10 (3), p. e0121878. ISSN 1932-6203 Haslam, I., Roubos, E., Mangoni, M., Yoshizato, K., Vaudry, H., Kloepper, J., Pattwell, D., Maderson, P. and Paus, R. (2014) ‘From frog integument to human skin: dermatological perspectives from frog skin biology’ Biological reviews of the Cambridge Philosophical Society , 89 (3), pp. 618-655. ISSN 1469-185X El-Chami, C., Haslam, I., Steward, M. and O'Neill, C. (2014) ‘Role of organic osmolytes in water homoeostasis in skin’ Experimental dermatology , 23 (8), pp. 534-537. ISSN 1600-0625 Kloepper, J., Ernst, N., Krieger, K., Bodó, E., Bíró, T., Haslam, I., Schmidt-Ullrich, R. and Paus, R. (2014) ‘NF-?B activity is required for anagen maintenance in human hair follicles in vitro’ The Journal of Investigative Dermatology , 134 (7), pp. 2036-2038. ISSN 1523-1747 Haslam, I. and Simmons, N. (2014) ‘Expression of the ABC transport proteins MDR1 (ABCB1) and BCRP (ABCG2) in bovine rumen’ Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology , 184 (5), pp. 673-681. ISSN 1432-136X Purba, T., Haslam, I., Poblet, E., Jiménez, F., Gandarillas, A., Izeta, A. and Paus, R. (2014) ‘Human epithelial hair follicle stem cells and their progeny: current state of knowledge, the widening gap in translational research and future challenges’ BioEssays : news and reviews in molecular, cellular and developmental biology , 36 (5), pp. 513-525. ISSN 1521-1878 Al-Nuaimi, Y., Hardman, J., Bíró, T., Haslam, I., Philpott, M., Tóth, B., Farjo, N., Farjo, B., Baier, G., Watson, R., Grimaldi, B., Kloepper, J. and Paus, R. (2014) ‘A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock’ The Journal of Investigative Dermatology , 134 (3), pp. 610-619. ISSN 1523-1747 Haslam, I., Pitre, A., Schuetz, J. and Paus, R. (2013) ‘Protection against chemotherapy-induced alopecia: targeting ATP-binding cassette transporters in the hair follicle?’ Trends in pharmacological sciences , 34 (11), pp. 599-604. ISSN 1873-3735 Hinde, E., Haslam, I., Schneider, M., Langan, E., Kloepper, J., Schramm, C., Zouboulis, C. and Paus, R. (2013) ‘A practical guide for the study of human and murine sebaceous glands in situ’ Experimental dermatology , 22 (10), pp. 631-637. ISSN 1600-0625 Meier, N., Haslam, I., Pattwell, D., Zhang, G., Emelianov, V., Paredes, R., Debus, S., Augustin, M., Funk, W., Amaya, E., Kloepper, J., Hardman, M. and Paus, R. (2013) ‘Thyrotropin-releasing hormone (TRH) promotes wound re-epithelialisation in frog and human skin’ PLoS ONE , 8 (9), p. e73596. ISSN 1932-6203 Paus, R., Haslam, I., Sharov, A. and Botchkarev, V. (2013) ‘Pathobiology of chemotherapy-induced hair loss’ The Lancet Oncology , 14 (2), p. e50-e59. ISSN 1474-5488 Wright, J., Haslam, I., Coleman, T. and Simmons, N. (2011) ‘Breast cancer resistance protein BCRP (ABCG2)-mediated transepithelial nitrofurantoin secretion and its regulation in human intestinal epithelial (Caco-2) layers’ European journal of pharmacology , 672 (1-3), pp. 70-76. ISSN 1879-0712 Haslam, I., Wright, J., O'Reilly, D., Sherlock, D., Coleman, T. and Simmons, N. (2011) ‘Intestinal ciprofloxacin efflux: the role of breast cancer resistance protein (ABCG2)’ Drug metabolism and disposition: the biological fate of chemicals , 39 (12), pp. 2321-2328. ISSN 1521-009X Haslam, I., O'Reilly, D., Sherlock, D., Kauser, A., Womack, C. and Coleman, T. (2011) ‘Pancreatoduodenectomy as a source of human small intestine for Ussing chamber investigations and comparative studies with rat tissue’ Biopharmaceutics & drug disposition , 32 (4), pp. 210-221. ISSN 1099-081X Lowes, S., Haslam, I., Fihn, B., Hilgendorf, C., Karlsson, J., Simmons, N. and Ungell, A. (2010) ‘The Effects of Pregnenolone 16?-Carbonitrile Dosing on Digoxin Pharmacokinetics and Intestinal Absorption in the Rat’ Pharmaceutics , 2 (1), pp. 61-77. ISSN 1999-4923 Brown, C., Sayer, R., Windass, A., Haslam, I., De Broe, M., D'Haese, P. and Verhulst, A. (2008) ‘Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling’ Toxicology and applied pharmacology , 233 (3), pp. 428-438. ISSN 1096-0333