Ginger, Michael - Huddersfield University - Department of Biological Sciences

个人简介

Michael graduated from the University of Liverpool in 1993 with a first class Honours degree in Biochemistry. He remained in Liverpool to complete his PhD, using classical biochemistry and analytical chemistry approaches to study lipid biosynthesis in pathogenic Leishmania and Trypanosoma parasites. The PhD was supervised by Drs John Goad and Michael Chance. A Wain Fellowship taken to the Universitat de Barcelona next saw Michael learn something of the molecular biology of lipid biosynthesis in plants before a return to Liverpool and post-doctoral research with Professor George Wolff. Here, the project involved application of analytical methods to address how seasonal deposition of organic matter helps support dynamic, diverse communities of large, sediment-feeding invertebrates in the deep-sea. Following the brief, but enjoyable, foray into deep-sea biology, Michael resumed his interest in parasites taking successive post-doctoral positions in the Universities of Glasgow (with Professor David Barry), Manchester, and Oxford (with Professor Keith Gull CBE FRS) to study the molecular and cellular biology of trypanosomes. Whilst in Oxford, Michael was awarded a Royal Society University Research Fellowship to study protist metabolism and cell biology and also held a non-stipendary lectureship with Brasenose College. He moved to Lancaster University in July 2007, stepping from his Royal Society Fellowship in 2011 as a senior lecturer, before promotion to Reader (2012) and finally Head of Division for Biomedical and Life Sciences (2015). Michael joined the University of Huddersfield as Professor of Biochemistry and Head of Department for Biological Sciences in April 2016.

研究领域

Working with a small research team and through collaboration with groups in the UK and abroad, Michael is interested in the atypical metabolism and evolutionary cell biology of parasitic and free-living protists. Ongoing projects include (i) characterisation of the unique way in which trypanosomatids (and their nearest relatives) add heme to their mitochondrial cytochromes c and (ii) metabolic flexibility in the alga Euglena gracilis – a distant relative to the parasitic trypanosomatids. In Huddersfield, Michael is also returning to the field of deep-sea biology using analytical and genomic approaches to understand how communities of sediment-feeding invertebrates thrive in deep-sea ocean plains despite a paucity of organic matter in these abyssal environments and thus, impact on carbon cycling. This work involves collaboration with Professor George Wolff from Earth, Ocean and Ecological Sciences at the University of Liverpool.

近期论文

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Gabaldón, T., Ginger, M. and Michels, P. (2016) ‘Peroxisomes in parasitic protists’ Molecular and Biochemical Parasitology . ISSN 0166-6851 Jackson, A., Otto, T., Aslett, M., Armstrong, S., Bringaud, F., Schlacht, A., Hartley, C., Sanders, M., Wastling, J., Dacks, J., Acosta-Serrano, A., Field, M., Ginger, M. and Berriman, M. (2016) ‘Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism’ Current Biology , 26 (2), pp. 161-172. ISSN 0960-9822 Sunter, J., Benz, C., Andre, J., Whipple, S., McKean, P., Gull, K., Ginger, M. and Lukes, J. (2015) ‘Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions’ Journal of Cell Science , 128 (16), pp. 3117-3130. ISSN 0021-9533 Shameer, S., Logan-Klumpler, F., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Butikofer, P., Cattanach, A., Bannerman-Chukualim, B., Creek, D., Crouch, K., de Koning, H., Denise, H., Ebikeme, C., Fairlamb, A., Ferguson, M., Ginger, M., Hertz-Fowler, C., Kerkhoven, E., Maser, P., Michels, P., Nayak, A., Nes, D., Nolan, D., Olsen, C., Silva-Franco, F., Smith, T., Taylor, M., Tielens, A., Urbaniak, M., van Hellemond, J., Vincent, I., Wilkinson, S., Wyllie, S., Opperdoes, F., Barrett, M. and Jourdan, F. (2015) ‘TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei’ Nucleic Acids Research , 43 (D1), p. D637-D644. ISSN 0305-1048 Moran, J., McKean, P. and Ginger, M. (2014) ‘Eukaryotic Flagella: Variations in Form, Function, and Composition during Evolution’ BioScience , 64 (12), pp. 1103-1114. ISSN 0006-3568 Ginger, M (2014) ‘Protein moonlighting in parasitic protists’ Biochemical Society Transactions , 42 (6), pp. 1734-1739. ISSN 0300-5127 Hayes, P., Varga, V., Olego-Fernandez, S., Sunter, J., Ginger, M. and Gull, K. (2014) ‘Modulation of a cytoskeletal calpain-like protein induces major transitions in trypanosome morphology’ The Journal of Cell Biology , 206 (3), pp. 377-384. ISSN 0021-9525 Voncken, F., Brown, R., Collingridge, P., Gull, K., Rigden, D. and Ginger, M. (2014) ‘Evidence for Loss of a Partial Flagellar Glycolytic Pathway during Trypanosomatid Evolution’ PLoS ONE , 9 (7), p. e103026. ISSN 1932-6203 Andre, J., Kerry, L., Qi, X., Hawkins, E., Drizyte, K., Ginger, M. and McKean, P. (2014) ‘An Alternative Model for the Role of RP2 Protein in Flagellum Assembly in the African Trypanosome’ Journal of Biological Chemistry , 289 (1), pp. 464-475. ISSN 0021-9258 Andre, J., Harrison, S., Towers, K., Qi, X., Vaughan, S., McKean, P. and Ginger, M. (2013) ‘The tubulin cofactor C family member TBCCD1 orchestrates cytoskeletal filament formation’ Journal of Cell Science , 126 (23), pp. 5350-5356. ISSN 0021-9533 Koumandou, V., Wickstead, B., Ginger, M., van der Giezen, M., Dacks, J. and Field, M. (2013) ‘Molecular paleontology and complexity in the last eukaryotic common ancestor’ Critical Reviews in Biochemistry and Molecular Biology , 48 (4), pp. 373-396. ISSN 1040-9238 Ginger, M., Collingridge, P., Brown, R., Sproat, R., Shaw, M. and Gull, K. (2013) ‘Calmodulin is Required for Paraflagellar Rod Assembly and Flagellum-Cell Body Attachment in Trypanosomes’ Protist , 164 (4), pp. 528-540. ISSN 1434-4610 Clarke, M., Lohan, A., Liu, B., Lagkouvardos, I., Roy, S., Zafar, N., Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T., Frech, C., Turcotte, B., Kopec, K., Synnott, J., Choo, C., Paponov, I., Finkler, A., Heng Tan, C., Hutchins, A., Weinmeier, T., Rattei, T., Chu, J., Gimenez, G., Irimia, M., Rigden, D., Fitzpatrick, D., Lorenzo-Morales, J., Bateman, A., Chiu, C., Tang, P., Hegemann, P., Fromm, H., Raoult, D., Greub, G., Miranda-Saavedra, D., Chen, N., Nash, P., Ginger, M., Horn, M., Schaap, P., Caler, L. and Loftus, B. (2013) ‘Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling’ Genome Biology , 14 (2), p. R11. ISSN 1465-6906 Basu, S., Leonard, J., Desai, N., Mavridou, D., Tang, K., Goddard, A., Ginger, M., Lukes, J. and Allen, J. (2013) ‘Divergence of Erv1-Associated Mitochondrial Import and Export Pathways in Trypanosomes and Anaerobic Protists’ Eukaryotic Cell , 12 (2), pp. 343-355. ISSN 1535-9778 Ginger, M., Sam, K. and Allen, J. (2012) ‘Probing why trypanosomes assemble atypical cytochromecwith an AxxCH haem-binding motif instead of CxxCH’ Biochemical Journal , 448 (2), pp. 253-260. ISSN 0264-6021 Jackson, A., Berry, A., Aslett, M., Allison, H., Burton, P., Vavrova-Anderson, J., Brown, R., Browne, H., Corton, N., Hauser, H., Gamble, J., Gilderthorp, R., Marcello, L., McQuillan, J., Otto, T., Quail, M., Sanders, M., van Tonder, A., Ginger, M., Field, M., Barry, J., Hertz-Fowler, C. and Berriman, M. (2012) ‘Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species’ Proceedings of the National Academy of Sciences , 109 (9), pp. 3416-3421. ISSN 0027-8424 Fritz-Laylin, L., Ginger, M., Walsh, C., Dawson, S. and Fulton, C. (2011) ‘The Naegleria genome: a free-living microbial eukaryote lends unique insights into core eukaryotic cell biology’ Research in Microbiology , 162 (6), pp. 607-618. ISSN 0923-2508 Brennand, A., Gualdrón-López, M., Coppens, I., Rigden, D., Ginger, M. and Michels, P. (2011) ‘Autophagy in parasitic protists: Unique features and drug targets’ Molecular and Biochemical Parasitology , 177 (2), pp. 83-99. ISSN 0166-6851 Duszenko, M., Ginger, M., Brennand, A., Gualdrón-López, M., Colombo, M., Coombs, G., Coppens, I., Jayabalasingham, B., Langsley, G., Lisboa de Castro, S., Menna-Barreto, R., Mottram, J., Navarro, M., Rigden, D., Romano, P., Stoka, V., Turk, B. and Michels, P. (2011) ‘Autophagy in protists’ Autophagy , 7 (2), pp. 127-158. ISSN 1554-8627 Ginger, M., Fritz-Laylin, L., Fulton, C., Cande, W. and Dawson, S. (2010) ‘Intermediary Metabolism in Protists: a Sequence-based View of Facultative Anaerobic Metabolism in Evolutionarily Diverse Eukaryotes’ Protist , 161 (5), pp. 642-671. ISSN 1434-4610