Georgopoulos, Nikolaos - Huddersfield University

个人简介

I did my BSc in Biochemistry & Genetics (1994-1997) and my PhD (1997-2001) in the Department of Biochemistry and Molecular Biology at the University of Leeds. I then worked as a post-doctoral research fellow firstly at the Cancer research UK Clinical centre, St James's Hospital in Leeds (2001-2005) and then at the Jack Birch Unit of Molecular Carcinogenesis, Department of Biology, University of York (2005-2008).

研究领域

I am interested in understanding the molecular aetiology of epithelial cancer development (activation of oncogenes, loss of tumour suppressor function, constitutive induction of cell proliferation and attenuation of pro-apoptotic pathways) and how the process of carcinogenesis itself affects the way epithelial cells respond to the immune system and its products, particularly in the context of proliferation, differentiation and apoptosis (cell death).

近期论文

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Baker, S., Shabir, S., Georgopoulos, N. and Southgate, J. (2016) ‘Ketamine-Induced Apoptosis in Normal Human Urothelial Cells’ The American Journal of Pathology . ISSN 0002-9440 Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D. and Georgopoulos, N. (2016) ‘Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process’ International Wound Journal . ISSN 1742-4801 Albarbar, B., Dunnill, C. and Georgopoulos, N. (2015) ‘Regulation of cell fate by lymphotoxin (LT) receptor signalling: Functional differences and similarities of the LT system to other TNF superfamily (TNFSF) members’ Cytokine & Growth Factor Reviews , 26 (6), pp. 659-671. ISSN 1359-6101 Rubenwolf, P., Thomas, C., Denzinger, S., Hartmann, A., Burger, M., Georgopoulos, N. and Otto, W. (2015) ‘Loss of AQP3 protein expression is associated with worse progression-free and cancer-specific survival in patients with muscle-invasive bladder cancer’ World Journal of Urology . ISSN 0724-4983 Al-Tameemi, W., Dunnill, C., Hussain, O., Komen, M., van den Hurk, C., Collett, A. and Georgopoulos, N. (2014) ‘Use of in vitro human keratinocyte models to study the effect of cooling on chemotherapy drug-induced cytotoxicity’ Toxicology in Vitro , 28 (8), pp. 1366-1376. ISSN 08872333 Georgopoulos, N., Kirkwood, L. and Southgate, J. (2014) ‘A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration’ Journal of Cell Science , 127 (13), pp. 2967-2982. ISSN 0021-9533 Kayamba, F., Dunnill, C., Hamnett, D., Rodríguez, A., Georgopoulos, N. and Moran, W. (2013) ‘Piperolein B, isopiperolein B and piperamide C9:1(8E): total synthesis and cytotoxicities’ RSC Advances , 3 (37), pp. 16681-16685. ISSN 2046-2069 Rubenwolf, P., Otto, W., Denzinger, S., Hofstädter, F., Wieland, W. and Georgopoulos, N. (2013) ‘Expression of aquaporin water channels in human urothelial carcinoma: correlation of AQP3 expression with tumour grade and stage.’ World journal of urology . ISSN 1433-8726 Rubenwolf, P., Georgopoulos, N., Kirkwood, L., Baker, S. and Southgate, J. (2012) ‘Aquaporin Expression Contributes to Human Transurothelial Permeability In Vitro and Is Modulated by NaCl’ PLoS ONE , 7 (9), p. e45339. ISSN 1932-6203 Georgopoulos, N., Kirkwood, L., Varley, C., Maclaine, N., Aziz, N. and Southgate, J. (2011) ‘Immortalisation of Normal Human Urothelial Cells Compromises Differentiation Capacity.’ European urology , 60 (1), pp. 141-149. ISSN 1873-7560 Georgopoulos, N., Kirkwood, L., Walker, D. and Southgate, J. (2010) ‘Differential Regulation of Growth-Promoting Signalling Pathways by E-Cadherin’ PLoS ONE , 5 (10), p. e13621. ISSN 1932-6203 Walker, D., Georgopoulos, N. and Southgate, J. (2010) ‘Anti-social cells: Predicting the influence of E-cadherin loss on the growth of epithelial cell populations’ Journal of Theoretical Biology , 262 (3), pp. 425-440. ISSN 0022-5193 Rubenwolf, P., Georgopoulos, N., Clements, L., Feather, S., Holland, P., Thomas, D. and Southgate, J. (2009) ‘Expression and Localisation of Aquaporin Water Channels in Human Urothelium In Situ and In Vitro’ European Urology , 56 (6), pp. 1013-1024. ISSN 0302-2838 Chopra, B., Georgopoulos, N., Nicholl, A., Hinley, J., Oleksiewicz, M. and Southgate, J. (2009) ‘Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels’ Cell Proliferation , 42 (5), pp. 688-700. ISSN 0960-7722 Walker, D., Georgopoulos, N. and Southgate, J. (2008) ‘From pathway to population - a multiscale model of juxtacrine EGFR-MAPK signalling’ BMC Systems Biology , 2 (1), p. 102. ISSN 1752-0509 Hill, K., Errington, F., Steele, L., Merrick, A., Morgan, R., Selby, P., Georgopoulos, N., O'Donnell, D. and Melcher, A. (2008) ‘OK432-Activated Human Dendritic Cells Kill Tumor Cells via CD40/CD40 Ligand Interactions’ Journal of Immunology , 181, pp. 3108-3115. ISSN 0022-1767 Kottke, T., Sanchez-Perez, L., Diaz, R., Thompson, J., Chong, H., Harrington, K., Calderwood, S., Pulido, J., Georgopoulos, N., Selby, P., Melcher, A. and Vile, R. (2007) ‘Induction of hsp70-Mediated Th17 Autoimmunity Can Be Exploited as Immunotherapy for Metastatic Prostate Cancer’ Cancer Research , 67 (24), pp. 11970-11979. ISSN 00085472 Georgopoulos, N., Merrick, A., Scott, N., Selby, P., Melcher, A. and Trejdosiewicz, L. (2007) ‘CD40-mediated death and cytokine secretion in colorectal cancer: A potential target for inflammatory tumour cell killing’ International Journal of Cancer , 121 (6), pp. 1373-1381. ISSN 00207136 Crallan, R., Georgopoulos, N. and Southgate, J. (2006) ‘Experimental models of human bladder carcinogenesis’ Carcinogenesis , 27 (3), pp. 374-381. ISSN 0143-3334 Steele, L., Georgopoulos, N., Southgate, J., Selby, P. and Trejdosiewicz, L. (2006) ‘Differential susceptibility to TRAIL of normal versus malignant human urothelial cells’ Cell Death and Differentiation , 13 (9), pp. 1564-1576. ISSN 1350-9047