Collett, Andrew - Huddersfield University

个人简介

My first degree was in Applied Biology at the University of Hatfield I then went on to do a PhD at the University of Newcastle upon Tyne researching the mechanism of novel epithelial chloride channel blockers. I then worked at the University of Manchester in the Departments of Medicine and Pharmacy investigating intestinal drug absorption using in vitro models. After that I moved to Dundee University where my main research interest was ion transport across the lung epithelia. I returned to work in the Department of Pharmacy at Manchester and continued my interest in intestinal drug absorption and the role of P-glycoprotein. Most recently I have worked in the Department of Translational Medicine in Manchester investigating intestinal inflammation and the importance of the interaction between P-glycoprotein and the enteric micro-flora. I was appointed as a Lecturer in Biological Sciences at Huddersfield in 2008 my main teaching is Cellular and Molecular Biology to MPharm students.

研究领域

I have two major areas of research, firstly an ongoing interest in the development of more predictive in vitro models of intestinal drug absorption particularly in the area of controlled release preparations and the potential modifying role of intestinal transport proteins. In addition I also conduct research in the area of intestinal inflammation particularly the interaction of the gut epithelial cells with the normal enteric microflora. This is tightly regulated in health but can be the source of significant pathology in susceptible individuals leading to chronic inflammatory conditions such as Crohn's disease and Ulcerative colitis. My work tries to understand at a molecular level the mechanisms that initiate the inflammatory response in intestinal epithelial cells.

近期论文

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Patten, D., Leivers, S., Chadha, M., Maqsood, M., Humphreys, P., Laws, A. and Collett, A. (2014) ‘The structure and immunomodulatory activity on intestinal epithelial cells of the EPSs isolated from Lactobacillus helveticus sp. Rosyjski and Lactobacillus acidophilus sp. 5e2.’ Carbohydrate Research , 384, pp. 119-127. ISSN 00086215 Patten, D. and Collett, A. (2013) ‘Exploring the immunomodulatory potential of microbial-associated molecular patterns derived from the enteric bacterial microbiota’ Microbiology , 159 (8), pp. 1535-1544. ISSN 1465-2080 Bannon, C., Davies, P., Collett, A. and Warhurst, G. (2009) ‘Potentiation of flagellin responses in gut epithelial cells by interferon-? is associated with STAT-independent regulation of MyD88 expression’ Biochemical Journal , 423 (1), pp. 119-128. ISSN 0264-6021 Collett, A., Higgs, N., Meritxell, G., Zeef, L., Hayes, A., Salmo, E., Haboubi, N., Iovanna, J., Carlson, G. and Warhurst, G. (2008) ‘Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(?/?) mice’ Inflammatory Bowel Diseases , 14 (5), pp. 620-631. ISSN 10780998 Collett, A (2008) ‘Investigation of Regional Mechanisms Responsible for Poor Oral Absorption in Humans of a Modified Release Preparation of the -Adrenoreceptor Antagonist, 4-Amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4 tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline (UK-338,003): The Rational Use of ex Vivo Intestine to Predict in Vivo Absorption’ Drug Metabolism and Disposition , 36 (1), pp. 87-94. ISSN 00909556 Collett, A., Tanianis-Hughes, J., Carlson, G., Harwood, M. and Warhurst, G. (2005) ‘Comparison of P-glycoprotein-mediated drug–digoxin interactions in Caco-2 with human and rodent intestine: Relevance to in vivo prediction’ European Journal of Pharmaceutical Sciences , 26 (5), pp. 386-393. ISSN 0928-0987 Collett, A., Tanianis-Hughes, J. and Warhurst, G. (2004) ‘Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?’ Biochemical Pharmacology , 68 (4), pp. 783-790. ISSN 0006-2952 Collett, A., Tanianis-Hughes, J., Hallifax, D. and Warhurst, G. (2004) ‘Predicting P-Glycoprotein Effects on Oral Absorption: Correlation of Transport in Caco-2 with Drug Pharmacokinetics in Wild-Type and mdr1a(-/-) Mice in Vivo’ Pharmaceutical Research , 21 (5), pp. 819-826. ISSN 0724-8741 Collett, A., Ramminger, S., Olver, R. and Wilson, S. (2002) ‘Beta-Adrenoceptor-mediated control of apical membrane conductive properties in fetal distal lung epithelia’ American journal of physiology - Lung cellular and molecular physiology , 282 (4), p. L621-L630. ISSN 1040-0605 Baines, D., Ramminger, S., Collett, A., Haddad, J., Best, O., Land, S., Olver, R. and Wilson, S. (2001) ‘Oxygen-evoked Na+ transport in rat fetal distal lung epithelial cells’ The Journal of Physiology , 532 (1), pp. 105-113. ISSN 0022-3751 Haddad, J., Collett, A., Land, S., Olver, R. and Wilson, S. (2001) ‘NF-?B Blockade Reduces the O2-Evoked Rise in Na+ Conductance in Fetal Alveolar Cells’ Biochemical and Biophysical Research Communications , 281 (4), pp. 987-992. ISSN 0006-291X Land, S. and Collett, A. (2001) ‘Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells’ Journal of Experimental Biology , 204 (4), pp. 785-795. ISSN 0022-0949 McAlroy, H., Ahmed, S., Day, S., Baines, D., Wong, H., Yip, C., Ko, W., Wilson, S. and Collett, A. (2000) ‘Multiple P2Y receptor subtypes in the apical membranes of polarized epithelial cells’ British Journal of Pharmacology , 131 (8), pp. 1651-1658. ISSN 0007-1188 Inglis, S., Collett, A., McAlroy, H., Wilson, S. and Olver, R. (1999) ‘Effect of luminal nucleotides on Cl - secretion and Na + absorption in distal bronchi’ Pflügers Archiv - European Journal of Physiology , 438 (5), pp. 621-627. ISSN 0031-6768 Ramminger, S., Collett, A., Baines, D., Murphie, H., McAlroy, H., Olver, R., Inglis, S. and Wilson, S. (1999) ‘P2Y2 receptor-mediated inhibition of ion transport in distal lung epithelial cells’ British Journal of Pharmacology , 128 (2), pp. 293-300. ISSN 0007-1188 Collett, A., Higgs, N., Sims, E., Rowland, M. and Warhurst, G. (1999) ‘Modulation of the Permeability of H2 Receptor Antagonists Cimetidine and Ranitidine by P-Glycoprotein in Rat Intestine and the Human Colonic Cell Line Caco-21’ The Journal of pharmacology and experimental therapeutics , 288 (1), pp. 178-178. ISSN 0022-3565