Clarke, Dougie - Huddersfield University - Department of Biological Sciences

个人简介

Dougie graduated from the University of Strathclyde in 1985 with a BSc in Biochemistry and subsequently gained a PhD in Biochemical pharmacology /toxicology from the Medical Sciences Institute, University of Dundee. He then worked as a Medical Research Council Post Doctoral Research Fellow in the department of Biochemical Medicine and subsequently in the department of Molecular Pathology at Ninewells Hospital and Medical School, Tayside researching the molecular basis of hereditary diseases (such as congenital jaundice) and metabolism of drugs by liver enzymes. From 1992 to 1998, he was a Lecturer in Molecular Medicine at the University of Dundee's Medical School. Dougie joined the department in 1998 as a Senior Lecturer and became Head of Biological Sciences & Nutrition in 2006. During his time here the number of biological sciences degrees have tripled (including one of the few medical genetics courses in the UK) and the first postgraduate bioscience masters course was initiated in 2005. In 2008 he led a major restructuring of biological sciences and nutrition in which six new lecturing staff were appointed from RAE5* rated groups to lead medical and food science research teams at Huddersfield. His main academic role is to lead, manage and teach on a suite of ten undergraduate BSc courses and two MSc courses. He is currently engaged on a diverse range of research projects encompassing the medical and biotechnology fields. At Huddersfield Dougie teaches predominantly on honours and postgraduate level modules which he is module leader of such as Applied Molecular Genetics, Bioinformatics, Molecular and Cellular Toxicology and Biochemical Methods. He is the University's representative for the Higher Education Academy Centre of Bioscience and serves on the several School committees including the Management Committee and School Board. Away from academia, Dougie enjoys travelling, mountain walking, studying wildlife and photography.

研究领域

Dougie's research team are currently involved in a diverse range of research projects encompassing the medical and biotechnology fields as follows: Khaled Al Salhen – Functional and molecular characterisation of molybdenum hydroxylases Tracey Cheetham - Characterisation of novel anaerobic cellulytic fungi using molecular genetic techniques Stuart Dent - Characterisation of novel sea anemone toxins (in collaboration with Integrin Advanced Biosystems) Dr Graham Williams - The use of novel methodologies to enhance DNA profiling from firearms and discharged cartridge casings Investigation of genetic mutations in rodenticide resistant rats Characterisation of human mesenchymal stem cells using proteomics

近期论文

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Gomes, V., Pala, M., Salas, A., Álvarez-Iglesias, V., Amorim, A., Gómez-Carballa, A., Carracedo, &., Clarke, D., Hill, C., Mormina, M., Shaw, M., Dunne, D., Pereira, R., Pereira, V., Prata, M., Sánchez-Diz, P., Rito, T., Soares, P., Gusmão, L. and Richards, M. (2015) ‘Mosaic maternal ancestry in the Great Lakes region of East Africa’ Human Genetics , 134 (9), pp. 1013-1027. ISSN 0340-6717 Connolly, J., Clarke, D. and Williams, G. (2011) ‘The use of forensic mRNA analysis to determine stain age’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 26. Uchimoto, M., Clarke, D. and Williams, G. (2011) ‘A novel method for the simultaneous co-isolation of DNA and mRNA for forensic casework samples’. In: Proceedings of the 7th National FORREST Conference 2011(FORensic RESearch and Teaching). Nottingham, UK: The Higher Education Academy UK Physical Sciences Centre in conjunction with Nottingham Trent University. p. 30. Soares, P., Rito, T., Trejaut, J., Mormina, M., Hill, C., Tinkler-Hundal, E., Braid, M., Clarke, D., Loo, J., Thomson, N., Denham, T., Donohue, M., Macaulay, V., Lin, M., Oppenheimer, S. and Richards, M. (2011) ‘Ancient Voyaging and Polynesian Origins’ The American Journal of Human Genetics , 88 (2), pp. 239-247. ISSN 00029297 Williams, G. and Clarke, D. (2010) ‘The use of multiple displacement amplification upon DNA recovered from discharged cartridge casings and shotgun shells’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK Connelly, J., Williams, G. and Clarke, D. (2010) ‘The development of an mRNA body fluid identification test utilising real-time PCR and the SYBR green fluorescent dye’. In: 6th National FORREST Conference 2010, 29th - 30th June 2010, Coventry, UK Hill, C., Soares, P., Mormina, M., Macaulay, V., Clarke, D., Blumbach, P., Vizuete-Forster, M., Forster, P., Bulbeck, D., Oppenheimer, S. and Richards, M. (2007) ‘A mitochondrial stratigraphy for Island Southeast Asia’ American Journal of Human Genetics , 80, pp. 29-43. ISSN 1537-6605 Hill, C., Soares, P., Mormina, M., Macaulay, V., Meehan, W., Blackburn, J., Clarke, D., Raja, J., Ismail, P., Bulbeck, D., Oppenheimer, S. and Richards, M. (2006) ‘Phylogeography and Ethnogenesis of Aboriginal Southeast Asians’ Molecular Biology and Evolution , 23 (12), pp. 2480-2491. ISSN 0737-4038 Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D., Meehan, W., Blackburn, J., Semino, O., Scozzari, R., Cruciani, F., Taha, A., Shaari, N., Raja, J., Ismail, P., Zainuddin, Z., Goodwin, W., Bulbeck, D., Bandelt, H., Oppenheimer, S., Torroni, A. and Richards, M. (2005) ‘A Response to Tracing Modern Human Origins’ Science , 309 (5743), p. 1995b-1997b. ISSN 0036-8075 Harpending, H., Eswaran, V., Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D. and Meehan, W. (2005) ‘Tracing Modern Human Origins’ Science , 309 (5743), p. 1995b-1997. ISSN 0036-8075 Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D., Meehan, W., Blackburn, J., Semino, O., Scozzari, R., Cruciani, F., Taha, A., Shaari, N., Raja, J., Ismail, P., Zainuddin, Z., Goodwin, W., Bulbeck, D., Bandelt, H., Oppenheimer, S., Torroni, A. and Richards, M. (2005) ‘Single, rapid coastal settlement of Asia revealed by analysis of complete mitochondrial genomes’ Science , 308 (5724), pp. 1034-1036. ISSN 0036-8075 Macaulay, V., Hill, C., Achilli, A., Rengo, C., Clarke, D. and Meehan, W. (2005) ‘Single, Rapid Coastal Settlement of Asia Revealed by Analysis of Complete Mitochondrial Genomes’ Science , 308 (5724), pp. 1034-1036. ISSN 0036-8075 Lee, W., McKiernan, P., Beath, S., Preece, M., Baty, D., Kelly, D., Burchell, B. and Clarke, D. (2001) ‘Bile bilirubin pigment analysis in disorders of bilirubin metabolism in early infancy’ Archives of Disease in Childhood , 85 (1), pp. 38-42. ISSN 00039888