Bryk, Jarek - Huddersfield University - Department of Biological Sciences

个人简介

I studied biology and obtained MSc in molecular biology from the University of Warsaw, Poland. Following my interest in science education and communication, after the university I co-founded and directed Science Festival School at the International Institute for Molecular and Cell Biology in Warsaw. It was one of the first full-time bioscience popularisation organisation in Poland and it is still active today as the Centre for Innovative Bioscience Education. Deciding to learn more and do research in evolutionary genetics, I started my PhD at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, where I worked on metabolic and behavioural consequences of expression of putatively adaptive human genes using transgenic mice. I generated mice transgenic for genes thought to be important in human evolution, like GLUD2, a hominoid-specific gene encoding neurotransmitter-degrading enzyme glutamate dehydrogenase or a group of genes including ASPM and CENPJ that play a role in brain development and whose mutations cause microcephaly in humans. During my PhD I become more interested in functional and mechanistic consequences of adaptive change, and followed this direction during a postdoc at the Max Planck Institute for Evolutionary Biology in Plön, Germany, where I worked on identification of putatively adaptive genes in wild, non-model organism using whole–genome approaches. I studied copy-number variants in natural (wild) populations of Mus musculus domestics using custom made microarrays and microsatellite scans to identify CNVs under selective sweeps. I then switched my focus back to teaching and education and became involved in secondary and undergraduate education in the National Centre for Biotechnology Education at the University of Reading, UK, where I undertook a EU–funded project to develop practical teaching resources in synthetic biology for undergraduates. I worked on development of DNA parts, plasmids and protocols to manipulate them, as well as organised workshops for undergraduates and A-level students in synthetic biology. I helped establish and mentored the first Reading team for the International Genetically Engineered Machines competition, where the student-driven project - construction and characterisation of solar-powered, cyanobacteria-based fuel cell - was awarded a bronze medal. My Marie-Curie fellowship was immediately followed with Wellcome Trust’s Society Award to NCBE, where I developed similar resources for A-level students. In April 2015 I was appointed as a Senior Lecturer at the University of Huddersfield.

研究领域

I am currently establishing a brand new research project to investigate evolutionary genetics of Apodemus mice and help turn it into a fully-fledged model organism to study genetics and genomics of adaptation. The first direction I undertake is investigation of population structure and phylogeography of Apodemus via the development of genetic markers to study DNA variation of two species, A. flavicolis and A. sylvaticus from the centre of their range in north-eastern Poland.

近期论文

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Li, Q., Guo, S., Jiang, X., Bryk, J., Naumann, R., Enard, W., Tomita, M., Sugimoto, M., Khaitovich, P. and Pääbo, S. (2016) ‘Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development’ Proceedings of the National Academy of Sciences , 113 (19), pp. 5358-5363. ISSN 0027-8424 Bryk, J. and Tautz, D. (2014) ‘Copy number variants and selective sweeps in natural populations of the house mouse (Mus musculus domesticus)’ Frontiers in Genetics , 5. ISSN 1664-8021 Reeves, R., Bryk, J., Altrock, P., Denton, J. and Reed, F. (2014) ‘First Steps towards Underdominant Genetic Transformation of Insect Populations’ PLoS ONE , 9 (5), p. e97557. ISSN 1932-6203 Kaderali, L., Pozhitkov, A., Noble, P., Bryk, J. and Tautz, D. (2014) ‘A Revised Design for Microarray Experiments to Account for Experimental Noise and Uncertainty of Probe Response’ PLoS ONE , 9 (3), p. e91295. ISSN 1932-6203 Bryk, J., Somel, M., Lorenc, A. and Teschke, M. (2013) ‘Early gene expression divergence between allopatric populations of the house mouse (Mus musculus domesticus)’ Ecology and Evolution , 3 (3), pp. 558-568. ISSN 20457758 Chan, Y., Jones, F., McConnell, E., Bryk, J., Bünger, L. and Tautz, D. (2012) ‘Parallel Selection Mapping Using Artificially Selected Mice Reveals Body Weight Control Loci’ Current Biology , 22 (9), pp. 794-800. ISSN 09609822 Lehane, M., Reeves, R., Denton, J., Santucci, F., Bryk, J. and Reed, F. (2012) ‘Scientific Standards and the Regulation of Genetically Modified Insects’ PLoS Neglected Tropical Diseases , 6 (1), p. e1502. ISSN 1935-2735 Wolf, J. and Bryk, J. (2011) ‘General lack of global dosage compensation in ZZ/ZW systems? Broadening the perspective with RNA-seq’ BMC Genomics , 12 (1), p. 91. ISSN 1471-2164 Pulvers, J., Bryk, J., Fish, J., Wilsch-Brauninger, M., Arai, Y., Schreier, D., Naumann, R., Helppi, J., Habermann, B., Vogt, J., Nitsch, R., Toth, A., Enard, W., Paabo, S. and Huttner, W. (2010) ‘Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline’ Proceedings of the National Academy of Sciences , 107 (38), pp. 16595-16600. ISSN 00278424 Stajich, J., Bryk, J., Hardouin, E., Pugach, I., Hughes, D., Strotmann, R., Stoneking, M. and Myles, S. (2008) ‘Positive Selection in East Asians for an EDAR Allele that Enhances NF-?B Activation’ PLoS ONE , 3 (5), p. e2209. ISSN 1932-6203 Semczuk, A., Lorenc, A., Putowski, L., Futyma, K., Bryk, J., Miotla, P. and Bartnik, E. (2006) ‘Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations’ Oncology Reports , 16 (5), pp. 1041-1045. ISSN 1021-335X Semczuk, A., Lorenc, A., Putowski, L., Bryk, J., Marzec, B. and Bartnik, E. (2006) ‘Mitochondrial Mutations in Primary Human Endometrial Carcinomas: Poster Session 3’ International Journal of Gynecological Cancer , 16 (s3), pp. 764-814. ISSN 1048-891X Heissig, F., Krause, J., Bryk, J., Khaitovich, P., Enard, W. and Pääbo, S. (2005) ‘Functional analysis of human and chimpanzee promoters’ Genome Biology , 6 (7), p. R57. ISSN 14656906 Lorenc, A., Bryk, J. and Bartnik, E. (2004) ‘Mitochondrial DNA in Tumors’ Toxicology Mechanisms and Methods , 14 (1-2), pp. 85-90. ISSN 1537-6516 Lorenc, A., Bryk, J., Golik, P., Kupryja?czyk, J., Ostrowski, J., Pronicki, M., Semczuk, A., Szo?kowska, M. and Bartnik, E. (2003) ‘Homoplasmic MELAS A3243G mtDNA mutation in a colon cancer sample’ Mitochondrion , 3 (2), pp. 119-124. ISSN 15677249