Allison, Simon - Huddersfield University - Department of Biological Sciences

个人简介

My first degree (First class honours) was in Natural Sciences (Biological) at the University of Cambridge specialising in Biochemistry in my final year. After this I decided to embark on a PhD after catching the ‘bug’ for research during a summer research placement in Edinburgh looking at apoptotic cells down the microscope! My PhD (University of Glasgow) focused on the deregulation of RNA polymerase III transcription in cancers and mechanistic studies relating to this. This was followed by my first post-doctoral position at the University of York within the group of Prof Jo Milner during which I identified a novel role for the tumour suppressor p53 in the regulation of global histone modifications. This was followed by a year’s teaching English as a Foreign Language in a town in Northern Greece before I returned to the UK to resume my scientific career. After further postdoctoral research positions at the Universities of York and Leeds, I began my independent research career at the Institute of Cancer Therapeutics of the University of Bradford after successfully securing my own external independent research funding as a PI. I joined the University of Huddersfield as a Senior Research Fellow within the Department of Pharmacy in August 2015.

研究领域

The focus of my research is on improving our understanding of the molecular and cellular biology of cancers with the aim of exploiting fundamental ‘basal' differences that exist between cancer and non-cancer cells for more selective targeting of cancers. Most currently used anti-cancer agents lack selectivity towards cancer cells and target both rapidly proliferating cancer and non-cancer cells. This leads to unpleasant side effects for the patient but also impacts on drug dosage that can be safely used and effectiveness of treatment. As a result, development of drug resistance and tumour recurrence are major problems. By focusing on the biology of cancers, and exploiting intricate cancer cell molecular dependencies or ‘addictions’ not shared by non-cancer cells, there is an opportunity to develop potent, more selective anti-cancer therapies and improve the selectivity of existing drugs. Other research interests include the development and utilisation of more physiologically relevant in vitro models for studying cancers as well as patient-derived in vitro models for studying tumor heterogeneity and variability in patient response to drugs. Another area of interest is the further development of novel siRNA/DNA constructs developed as potential experimental and therapeutic tools. Specific current research interests include:- Exploitation of cancer cell metabolic re-wiring The sirtuins and other NAD+-dependent enzymes Molecular addictions/dependencies of cancer cells Inter- and intra-cellular crosstalk Regulation of epigenetic alterations in cancer cells Elucidation of mechanisms of action of novel anti-cancer agents

近期论文

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Elkashef, S., Allison, S., Sadiq, M., Basheer, H., Ribeiro Morais, G., Loadman, P., Pors, K. and Falconer, R. (2016) ‘Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment’ Scientific Reports , 6, p. 33026. ISSN 2045-2322 Lord, R., Allison, S., Rafferty, K., Ghandhi, L., Pask, C. and McGowan, P. (2016) ‘Cytotoxic Hydrogen Bridged Ruthenium Quinaldamide Complexes Showing Induced Cancer Cell Death by Apoptosis’ Dalton Trans. . ISSN 1477-9226 Lucas, S., Lord, R., Basri, A., Allison, S., Phillips, R., Blacker, A. and McGowan, P. (2016) ‘Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes’ Dalton Transactions (16). ISSN 1477-9226 Kaner, R., Allison, S., Faulkner, A., Phillips, R., Roper, D., Shepherd, S., Simpson, D., Waterfield, N. and Scott, P. (2015) ‘Anticancer metallohelices: nanomolar potency and high selectivity’ Chemical Science . ISSN 2041-6520 Lord, R., Hebden, A., Pask, C., Henderson, I., Allison, S., Shepherd, S., Phillips, R. and McGowan, P. (2015) ‘Hypoxia Sensitive Metal ?-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis’ Journal of Medicinal Chemistry , 58 (12), pp. 4940-4953. ISSN 0022-2623 Allison, S., Knight, J., Granchi, C., Rani, R., Minutolo, F., Milner, J. and Phillips, R. (2014) ‘Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways’ Oncogenesis , 3 (e102), pp. 1-11. ISSN 2157-9024 Allison, S. and Milner, J. (2014) ‘RNA Interference by Single- and Double-stranded siRNA With a DNA Extension Containing a 3? Nuclease-resistant Mini-hairpin Structure’ Molecular Therapy—Nucleic Acids , 2 (12), p. e141. ISSN 2162-2531 Ahmadi, M., Ahmadihosseini, Z., Allison, S., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. and Phillips, R. (2014) ‘Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors’ British Journal of Pharmacology , 171 (1), pp. 224-236. ISSN 0007-1188 Knight, J., Allison, S. and Milner, J. (2013) ‘Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity’ Open Biology , 3 (11), pp. 130130-130130. ISSN 2046-2441 Shah, Z., Ahmed, S., Ford, J., Allison, S., Knight, J. and Milner, J. (2012) ‘A Deacetylase-Deficient SIRT1 Variant Opposes Full-Length SIRT1 in Regulating Tumor Suppressor p53 and Governs Expression of Cancer-Related Genes’ Molecular and Cellular Biology , 32 (3), pp. 704-716. ISSN 0270-7306 Milner, J. and Allison, S. (2011) ‘SIRT1, p53 and mitotic chromosomes’ Cell Cycle , 10 (18), pp. 3049-3049. ISSN 1538-4101 Blagosklonny, M., Lynch, C., Shah, Z., Allison, S., Ahmed, S., Ford, J., Warnock, L., Li, H., Serrano, M. and Milner, J. (2010) ‘SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53’ PLoS ONE , 5 (10), p. e13502. ISSN 1932-6203 Allison, S., Jiang, M. and Milner, J. (2009) ‘Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells’ Aging , 1 (3), pp. 316-327. Ford, J., Ahmed, S., Allison, S., Jiang, M. and Milner, J. (2008) ‘JNK2-dependent regulation of SIRT1 protein stability’ Cell Cycle , 7 (19), pp. 3091-3097. ISSN 1538-4101 Allison, S. and Milner, J. (2007) ‘SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways’ Cell Cycle , 6 (21), pp. 2669-2677. ISSN 1538-4101 Allison, S. and Milner, J. (2004) ‘Remodelling chromatin on a global scale: a novel protective function of p53’ Carcinogenesis , 25 (9), pp. 1551-1557. ISSN 1460-2180 Allison, S. and Milner, J. (2003) ‘Loss of p53 has site-specific effects on histone H3 modification, including serine 10 phosphorylation important for maintenance of ploidy’ Cancer Research , 63 (20), pp. 6674-6679. ISSN 0008-5472 Johnston, I., Allison, S., Morton, J., Schramm, L., Scott, P. and White, R. (2002) ‘CK2 Forms a Stable Complex with TFIIIB and Activates RNA Polymerase III Transcription in Human Cells’ Molecular and Cellular Biology , 22 (11), pp. 3757-3768. ISSN 0270-7306, Sutcliffe, J., Brown, T., Allison, S., Scott, P. and White, R. (2000) ‘Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription’ Molecular and Cellular Biology , 20 (24), pp. 9192-9202. ISSN 0270-7306 Winter, A., Sourvinos, G., Allison, S., Tosh, K., Scott, P., Spandidos, D. and White, R. (2000) ‘RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors’ Proceedings of the National Academy of Sciences , 97 (23), pp. 12619-12624. ISSN 0027-8424