Williams, Graham - Huddersfield University - Department of Chemistry and Chemical Engineering

个人简介

Graham Williams graduated from the University of Leeds in 1998 with a BSc (Hons) in Physiology. He then went on to do an MSc in Neurosciences at the Institute of Psychiatry, King’s College London. His research thesis was titled 'The signal transduction pathways of the abnormal prion protein'. He has a PhD from the University of Huddersfield with the thesis title of ‘Identification and Resolution of Capability Gaps in Forensic Science’, which is centred around forensic genetics. From 1999 to 2002, Graham worked in the Neurosciences Group of the Weatherall Institute of Molecular Medicine at the University of Oxford researching the auto-immune aspects of epilepsy - investigating possible treatment pathways for disorders such as Rasmussen's encephalitis and Guillain Barre Syndrome. In April 2002, Graham became a Forensic Biologist for the London laboratory of the Forensic Science Service (then part of the Home Office). During this time, Graham reported hundreds of cases ranging from volume crime such as 'taking without consent' and muggings through to sexual offences, homicides and terrorism cases. He developed particular expertise with interpreting DNA profiling results from firearms. He has forensic expertise in Body Fluid evidence, DNA profiling, Bloodstain Pattern Analysis and Clothing Damage Analysis. He is also an expert witness with court-going experience. In 2007, Graham became a Lecturer in Forensic Science in the School of Applied Sciences, where he lectures in Crime Scene Investigations, Forensic Investigations and Forensic Science and the Law. He also provides workshops on Bloodstain Pattern Analysis (BPA). Graham also developed and is course leader for the MSc Forensic Science suite of courses. Graham has extensive research interests, but his main research strand is Forensic RNA Analysis for body fluid identification and time-since-deposition of stains – managing a large team working in this field and has extensive publications and conference presentations in this field. He also has research interests in clothing damage analysis and bloodstain pattern analysis. In his professional capacity, Graham also acts as a Consultant Forensic Biologist for a number of organisations; including a governmental organisation and an overseas company. He is also a reporting forensic scientist on an ad hoc basis for various organisations, providing reports for both the prosecution and the defence. He is extremely experienced in case work, having examined thousands of items for body fluids, DNA, BPA, and clothing damage. As a predominantly defence expert witness, he currently averages about 15-20 cases per year.

研究领域

Investigating the auto-immune aspects of epilepsy, such as that in Rasmussen's Encephalitis, Guillian-Barre Syndrome and Systemic Lupus Erythematosus (SLE). This research was also looking to improve therapy for infection induced seizures, such as those exhibited in patients with Falciparum Malaria. Current Research I am currently carrying out research in to: Forensic messenger RNA analysis for body fluid identification (BFID) Forensic micro RNA analysis for body fluid identification Developing strategies for the interpretation of miRNA BFID results Developing optimal DNA recovery methods for various surfaces Developing strategies for RNA based stain age determination Clothing damage analysis Bloodstain pattern analysis

近期论文

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Jung, S., Cho, S., Antunes, J., Gomes, I., Uchimoto, M., Oh, Y., Giacomo, L., Schneider, P., Park, M., van der Meer, D., Williams, G., McCord, B., Ahn, H., Choi, D., Lee, Y., Lee, S. and Lee, H. (2016) ‘A collaborative exercise on DNA methylation-based body fluid typing’ ELECTROPHORESIS . ISSN 0173-0835 Bexon, K. and Williams, G. (2015) ‘Characterising the fluctuation of microRNA expression throughout a full menstrual cycle’ Forensic Science International: Genetics Supplement Series , 5, pp. 264-266. ISSN 1875-1768 Bexon, K. and Williams, G. (2015) ‘Characterising the fluctuation of microRNA expression throughout a full menstrual cycle’ Forensic Science International: Genetics Supplement Series , 5, pp. 264-266. ISSN 1875-1768 van der Meer, D. and Williams, G. (2015) ‘Performing Body Fluid Identification using a MicroRNA Multiplex with Capillary Electrophoresis’. In: 26th Congress of the International Society for Forensic Genetics, 31st August - 5th September 2015, Poland Rada, N., van der Meer, D., Uchimoto, M. and Williams, G. (2015) ‘Methylation profiling of ELOVL2 for age prediction in forensic investigations using SNaPshot’. In: 7th European Academy of Forensic Science Conference, 6th - 11th September 2015, Prague Bexon, K. and Williams, G. (2015) ‘Body Fluid Specific Micro-RNA Markers: Characterising the Fluctuation of Expression in Vaginal Material when Analysed Over a Full Menstrual Cycle’. In: 26th Congress of the International Society for Forensic Genetics, 31st August - 5th September 2015, Poland Bexon, K. and Williams, G. (2015) ‘Body Fluid Specific Micro-RNA Markers: Characterising the Fluctuation of Expression in Vaginal Material when Analysed Over a Full Menstrual Cycle’. In: 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Individualized Medicine, 22nd - 26th June 2015, Croatia van der Meer, D. and Williams, G. (2015) ‘On combining microRNA analysis with DNA profiling in a single stream process’. In: American Academy of Forensic Sciences 67th Annual Meeting, Orlando, FL, USA, 16th - 21st February 2015, Orlando, FL, USA , p. 935 Stewart, L., Evans, N., Bexon, K., van der Meer, D. and Williams, G. (2015) ‘Differentiating between monozygotic twins through DNA methylation specific high resolution melt curve analysis’ Analytical Biochemistry . ISSN 0003-2697 Dunnett, H., Williams, G. and Van der Meer, D. (2015) ‘Evaluation of Stem-Loop Reverse Transcription and Poly-A Tail Extension in MicroRNA Analysis of Body Fluids’ MicroRNA , 4. ISSN 2211-5366 Bexon, K. and Williams, G. (2014) ‘Characterising changes in expression of body fluid specific microRNA markers in vaginal material over a 31 day period’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece Stewart, L., Evans, N., Bexon, K., van der Meer, D. and Williams, G. (2014) ‘Differentiating between monozygotic twins through methylation specific high resolution melt curve analysis’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece Uchimoto, M., Coult, N. and Williams, G. (2014) ‘Characterisation of OFMIR-205,MIR-451 and RNU44 in blood and saliva samples’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece van der Meer, D., Uchimoto, M. and Williams, G. (2014) ‘Combining microRNA analysis with DNA profiling in a single stream process’. In: International Society for Forensic Genetics English Speaking Working Group Annual Meeting, 28th - 31st May 2014, Athens, Greece Williams, G (2014) ‘Latest Developments in Forensic Applications in MicroRNA Analysis’. In: Forensic Europe Expo 2014, 29th - 30th April 2014, London, UK Williams, G., Connolly, J., Omelia, E., Beasley, E. and Gaduzo, D. (2013) ‘Characterising degradation profiles of RNA molecules within blood stains: Pilot studies’. In: Advances in Temporal Forensic Investigations, 4th-5th November 2013, Huddersfield, UK Williams, G., Uchimoto, M., Coult, N., World, D. and Beasley, E. (2013) ‘Body fluid mixtures; resolution using forensic microRNA analysis’ Forensic Science International: Genetics Supplement Series , 4 (1), pp. 292-293. ISSN 1875-1768 Williams, G., Uchimoto, M., Coult, N., World, D., Beasley, E. and Avenell, P. (2013) ‘Characterisation of body fluid specific microRNA markers by capillary electrophoresis’ Forensic Science International: Genetics Supplement Series , 4 (1), pp. 274-275. ISSN 1875-1768 Williams, G., Uchimoto, M., Coult, N., World, D. and Beasley, E. (2013) ‘Body fluid mixtures; resolution using forensic microRNA analysis’. In: The 25th World Congress of the International Society for Forensic Genetics, 2nd-7th September 2013, Melbourne, Australia , p. 172 Williams, G., Uchimoto, M., Coult, N., World, D., Beasley, E. and Avenell, P. (2013) ‘Characterisation of body fluid specific microRNA markers by capillary electrophoresis’. In: The 25th World Congress of the International Society for Forensic Genetics, 2nd-7th September 2013, Melbourne, Australia , p. 171