Zhi, LI - National University of Singapore - Department of Chemical and Biomolecular Engineering

个人简介

PhD (Org. Chem.) University of Vienna, Austria, 1991 MEng (Chem. Eng.) Chinese Academy of Forestry, Nanjing, China, 1985 BSc (Chem.) Nanjing University, China, 1982

研究领域

1. Discovery of Enzymes for Green and Selective Reactions 2. Engineering of Enzymes for Efficient Biocatalysis 3. Engineering of Biocatalytic Systems for Cascade Reactions 4. Conversion of Biomass to Fuel and Chemicals 5. Engineering of Active and Recyclable Nano-biocatalysts 6. Development of Smart Materials for Biomedical Application

近期论文

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Xin, R., See, W.W.L., Li, X., Yun, H., & Li, Z.* Enzyme-Catalyzed Meinwald Rearrangement with an Unusual Regioselective and Stereospecific 1,2-Methyl Shift. Angewandte Chemie, 2022, Angewandte Chemie, doi: 10.1002/anie.202204889. Li, R., Tian, K., Li, X., Gaikaiwari, A.R., & Li, Z.* Engineering P450 Monooxygenases for Highly Regioselective and Active p-Hydroxylation of m-Alkylphenols. ACS Catalysis, 2022, 12, 5939–5948, doi: 10.1021/acscatal.1c06011. Sekar, B.S., Li, X. & Li, Z.* Bioproduction of Natural Phenethyl Acetate, Phenylacetic Acid, Ethyl Phenylacetate, and Phenethyl Phenylacetate from Renewable Feedstock. ChemSusChem, 2022, e202102645, doi: 10.1002/cssc.202102645. Lukito, B.R., Wang, Z., Sekar, B.S., & Li, Z.* Production of (R)-mandelic acid from styrene, L-phenylalanine, glycerol, or glucose via cascade biotransformations. Bioresources and Bioprocessing, 2021, 8: 22, doi: 10.1186/s40643-021-00374-6. Choo, J. P. S., Kammerer, R., Li, X., & Li, Z.* High-level production of phenylacetaldehyde using fusion-tagged styrene oxide isomerase. Advanced Synthesis & Catalysis, 2021, 363: 1714-1721, doi: 10.1002/adsc.202001500. Wang, Z., Sekar B.S., & Li, Z.* Recent advances in artificial enzyme cascades for the production of value-added chemicals. Bioresource Technology, 2021, 323: 124551, doi: 10.1016/j.biortech.2020.124551. Sekar, B.S., Mao J., Lukito B.R., Wang, Z., & Li, Z.* Bioproduction of enantiopure (R)- and (S)-2-phenylglycinols from styrenes and renewable feedstocks. Advanced Synthesis & Catalysis, 2021, 363: 1892-1903, doi: 10.1002/adsc.202001322. Selected as Very Important Paper and published in journal's front cover. Tian, K., & Li, Z.* A simple biosystem for the high-yielding cascade conversion of racemic alcohols to enantiopure amines. Angewandte Chemie, 2020, 59: 21745-21751, doi: 10.1002/anie.202009733. Zhou, Y., Sekar, B. S., Wu, S., & Li, Z.* Benzoic acid production via cascade biotransformation and coupled fermentation-biotransformation. Biotechnology and Bioengineering, 2020, 117: 2340-2350, doi: 10.1002/bit.27366. Yuan J., Lukito B.R., & Li, Z.* De novo biosynthesis of (S)- and (R)-phenylethanediol in yeast via artificial enzyme cascades. ACS Synthetic Biology, 2019, 8: 1801-1808, doi: 10.1021/acssynbio.9b00123. Sekar B.S., Lukito B.R., & Li, Z.* Production of natural 2-phenylethanol from glucose or glycerol with coupled Escherichia coli strains expressing L-phenylalanine biosynthesis pathway and artificial biocascades. ACS Sustainable Chemistry & Engineering, 2019, 14: 12231-12239, doi: 10.1021/acssuschemeng.9b01569. Liu, J., & Li, Z.* Enhancing cofactor recycling in the bioconversion of racemic alcohols to chiral amines with alcohol dehydrogenase and amine dehydrogenase by coupling cells and cell-free system. Biotechnology and Bioengineering, 2019, 116: 536-542, doi: 10.1002/bit.26896. Lukito B.R., Wu S., Saw H.J.J., & Li, Z.* One-pot production of natural 2-phenylethanol from L-phenylalanine via cascade biotransformations. ChemCatChem, 2019, 11: 831-840, doi: 10.1002/cctc.201801613. Wu S., Zhou Y., & Li, Z.* Biocatalytic selective functionalisation of alkenes: Via single-step and one-pot multi-step reactions. Chemical Communications, 2019, 55: 883-896, doi: 10.1039/C8CC07828A. Lukito B.R., Sekar B.S., Wu S., & Li, Z.* Whole cell-based cascade biotransformation for the production of (S)-mandelic acid from styrene, L-phenylalanine, glucose, or glycerol. Advanced Synthesis & Catalysis, 2019, 361: 3560-3568, doi: 10.1002/adsc.201900373. Cui H.-B., Xie L.-Z., Wan N.-W., He Q., Li, Z., Chen Y.-Z.* Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons. Green Chemistry, 2019, 21: 4324-4328, doi: 10.1039/C9GC01802F. Zeng, S.,Liu, J., Anankanbil, S., Chen, M., Guo, Z., Adams, J.P., Snajdrova, R.& Li, Z.* Amide synthesis via aminolysis of ester or acid with an intracellular lipase. ACS Catalysis, 2018, 8: 8856-8865, doi: 10.1021/acscatal.8b02713. Vahidi, A. K., Wang, Z., & Li, Z.* Facile synthesis of S-substituted L-cysteines with nano-sized immobilized O-acetylserine sulfhydrylase. ChemCatChem, 2018, 10: 3671-3674. Zhou, Y., Wu, S., Mao, J., & Li, Z.* Bioproduction of benzylamine from renewable feedstocks via a nine-step artificial enzyme cascade and engineered metabolic pathways. ChemSusChem, 2018, 11: 2221-2228. Liu, J., Wu, S., & Li, Z.* Recent advances in enzymatic oxidation of alcohols. Current Opinion in Chemical Biology, 2018, 43: 77-86.