Sweeney, Joe - Huddersfield University - Department of Chemistry and Chemical Engineering

个人简介

Joe was awarded a BSc in Chemistry and elected an Associate of the Royal College of Science at Imperial College in 1984, then carried out a PhD studying synthetic uses of aziridines and allylstannanes with Prof. J. E. Baldwin in the Dyson Perrins Lab at the University of Oxford in the period 1984-87. During this period, the first ring-openings of enantiomerically-pure aziridines were discovered. Joe continued his research career as a Royal Society Fellow in the group of Prof. Steve Benner at ETH Zürich (1988-89), before returning to the UK as a lecturer in the Department of Chemistry at the University of Leicester. In 1990 Joe was appointed as Lecturer in Chemistry at the University of Bristol where he developed research projects focused on new methods for preparation and use of polyhydroxylated ring structures, aziridines and metalled furanones, and the total synthesis of several naturally-occurring lactones. In 1996, he moved to a Readership in Organic Chemistry at the University of Reading, where his research expanded into asymmetric methodology, his group delivering new methods for preparation of chiral aziridines and describing the first asymmetric [2,3]-sigmatropic rearrangements of ammonium ylids. In 2007 Joe was awarded the inaugural Faculty Output Prize at the University of Reading for his group's publication on asymmetric rearrangements, and he became Professor of Synthesis and Chemical Biology. In 2008, Joe was awarded a Royal Society Industry Fellowship to collaborate with AstraZeneca Pharmaceuticals; after two years of vibrant collaborative interactions, the Fellowship was extended (for only the second time in the history of the programme) to enable expansion of the new networking model for chemistry collaborations which had been devised during the first Fellowship. In 2011 Joe was appointed to a research chair at Huddersfield.

研究领域

Joe's research group are currently exploring two broad areas of chemical research: catalyzed synthesis and chemical biology. The research programmes in progress included new methods for direct functionalization of heterocycles (research sponsored by AstraZeneca Pharmaceuticals and EPSRC); catalytic tandem bond-forming reactions of reactive intermediates (AZ/EPSRC); new methods for introduction of fluorine into drug-like cores (AZ/EPSRC); rapid C-alkylation of peptides and proteins (EPSRC); new imaging agents for in vivo tracing and mechanistic studies (EPSRC). In addition to research activities, Joe is a passionate advocate for and deliverer of positive outreach activities; he has also appeared in films highlighting the activities of the Royal Society during its 350th anniversary, culminating in his participation in the Convocation of 2010. Joe believes science is about making life better and his aim is to help make a positive contribution towards achieving that aim.

近期论文

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Andrews, D., Broad, L., Edwards, P., Fox, D., Gallagher, T., Garland, S., Kidd, R. and Sweeney, J. (2016) ‘The creation and characterisation of a National Compound Collection: the Royal Society of Chemistry pilot’ Chemical Science , 7 (6), pp. 3869-3878. ISSN 2041-6520 Elmekawy, A., Sweeney, J. and Brown, D. (2015) ‘Efficient synthesis of supported proline catalysts for asymmetric aldol reactions’ Catalysis Science & Technology , 5 (2), pp. 690-696. ISSN 2044-4753 Hill, G. and Sweeney, J. (2015) ‘Reaction Workup Planning: A Structured Flowchart Approach, Exemplified in Difficult Aqueous Workup of Hydrophilic Products’ Journal of Chemical Education , 92 (3), pp. 488-496. ISSN 0021-9584 Sweeney, J., Gill, D., McLay, N., Waring, M. and Wilkinson, C. (2014) ‘An Improved Method for Difluorocyclopropanation of Alkenes’ Synlett , 25 (12), pp. 1756-1758. ISSN 0936-5214 Sweeney, J. and Walsh, A. (2014) ‘1.16 Epoxidation and Related Processes’. In: Comprehensive Organic Synthesis II. : Elsevier. pp. 609-652. ISBN 978-0-08-097743-0 Ochocinska, A., Bethel, P. and Sweeney, J. (2013) ‘Catalytic Synthesis of Riboside-Amino Acid Hybrids’ Synlett , 24 (16), pp. 2170-2172. ISSN 0936-5214 Pugh, V., Matthews, T., Powell, L., Sweeney, J. and Rattray, M. (2013) ‘The development of riluzole derivatives with improved potency’. In: 24th Biennial Meeting of the International-Society-for-Neurochemistry and the American Society for Neurochemistry, 20th-24th April 2013, Cancun, Mexico , pp. 272-272 Jarvis, A., McLaren, A., Osborn, H. and Sweeney, J. (2013) ‘Preparation and ring-opening reactions ofN-diphenylphosphinyl vinyl aziridines’ Beilstein Journal of Organic Chemistry , 9, pp. 852-859. ISSN 1860-5397 Murray, P., Bower, J., Cox, D., Galbraith, E., Parker, J. and Sweeney, J. (2013) ‘A Robust First-Pass Protocol for the Heck–Mizoroki Reaction’ Organic Process Research & Development , 17 (3), pp. 397-405. ISSN 1083-6160 Sweeney, J. and Hudson, J. (2012) ‘An Efficient Method for Reductive Amination of Carbonyl Compounds under Nonacidic Conditions’ Synlett , 23 (15), pp. 2176-2178. ISSN 0936-5214 Goldberg, K., Groombridge, S., Hudson, J., Leach, A., MacFaul, P., Pickup, A., Poultney, R., Scott, J., Svensson, P. and Sweeney, J. (2012) ‘Oxadiazole isomers: all bioisosteres are not created equal’ MedChemComm , 3 (5), p. 600. ISSN 2040-2503 Sweeney, J. and Sançon, J. (2010) ‘Probing the Effect of Allylic Substitution on Cyclic Ammonium Ylid Rearrangements’ Synlett , 2010 (04), pp. 664-666. ISSN 0936-5214 Sweeney, J (2009) ‘Aziridine Synthesis via Nucleophilic Attack of Carbene Equivalents on Imines: the Aza-Darzens Reaction’ European Journal of Organic Chemistry , 2009 (29), pp. 4911-4919. ISSN 1434-193X Sweeney, J (2009) ‘Sigmatropic rearrangements of ‘onium’ ylids’ Chemical Society Review , 38 (4), pp. 1027-1038. ISSN 0306-0012 Sweeney, J (2008) ‘Aziridines’. In: Science of Synthesis. Stuttgart: Thieme. pp. 643-772. ISBN 9783131189318 Norman, D., Carraz, C., Hyett, D., Pringle, P., Sweeney, J., Orpen, A., Phetmung, H. and Wingad, R. (2008) ‘Bidentates versus Monodentates in Asymmetric Hydrogenation Catalysis: Synergic Effects on Rate and Allosteric Effects on Enantioselectivity’ Journal of the American Chemical Society , 130 (21), pp. 6840-6847. ISSN 0002-7863 Sweeney, J. and Sançon, J. (2008) ‘A Low-Temperature Ammonium Ylid Rearrangement: Enhanced Reactivity Engendered by Rigidity’ Synlett , 2008 (14), pp. 2213-2214. ISSN 0936-5214 Ochocinska, A. and Sweeney, J. (2007) ‘Stereoselective addition to furanones’. In: The 234th ACS National Meeting, 19th - 23rd August 2007, Boston, MA, USA Tran, F. and Sweeney, J. (2007) ‘[2,3]-Sigmatropic rearrangement of benzofused oxonium and ammonium ylids’. In: National meeting, American Chemical Society, 19-23rd August 2007, Boston Ponce, M. and Sweeney, J. (2007) ‘Asymmetric [1,2]-sigmatropic rearrangement of benzylic ammonium ylids’. In: The 234th ACS National Meeting, 19th - 23rd August 2007, Boston, MA, USA