Hemming, Karl - Huddersfield University - Department of Chemistry and Chemical Engineering

个人简介

First degree: BSc(Hons) Applied Chemistry, University of Salford (1989). PhD: Synthetic Organic Chemistry (Synthesis of Four Membered Ring Nitrogen Heterocycles) supervised by Dr R K Smalley, University of Salford (1993). Postdoctoral work (1993 - 1995): Universities of East Anglia and York with Professor R J K Taylor on the synthesis of polyene natural products, such as vitamin A, using pyrylium heterocycles. I lectured in organic chemistry at the Universities of Bath (1995 - 1996) and Hertfordshire (1996 - 2001), before being appointed to the staff at the University of Huddersfield in August 2001, where I am currently Reader in Organic Chemistry and Course Leader for Chemical Sciences. Teaching Areas: foundations of organic chemistry, functional group chemistry, pharmaceutical chemistry for pharmacy students, organic chemistry for forensic sciences, carbonyl chemistry, organic synthesis, techniques of practical organic chemistry. Other Duties: Year Tutor for Year 2 MChem; Course Leader for Chemistry and Forensic & Analytical Science. External roles: Secretary and Treasurer of the Royal Society of Chemistry Heterocyclic and Synthesis Group 2008-2011 with responsibility for the organisation of the Grasmere Heterocyclic Symposium 2009 and 2011; board of referees for the journal Tetrahedron; regular reviewer for the Journal of Chemical Research, and reviewer for Journal of Organic Chemistry, Tetrahedron Letters and Organic Letters.

研究领域

Small ring heterocycles: The synthesis and chemistry of bicyclic β-lactams and sultams The Synthesis of Benzodiazepines and Related Systems with Potential Biological Activity Applications of the aza-Wittig Reaction in Organic Synthesis The Synthesis of Alkaloid Natural Product Analogues

近期论文

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Hemming, K., Blackburn, J., Molyneux, G., Pitard, A., Rice, C., Page, M., Afshinjavid, S., Javid, F., Coles, S. and Horton, P. (2016) ‘Synthesis, Conformation and Antiproliferative Activity of Isothiazoloisoxazole 1,1-dioxides’ Organic and Biomolecular Chemistry , 14, pp. 2134-2144. ISSN 1477-0539 Hemming, K., Jamshaid, F. and Khan, M. (2015) ‘2-Methylsulfanylbenzo[f]isoquinoline’ Molbank , 2015 (M860), pp. 1-5. ISSN 1422-8559 Hemming, K., Chambers, C., Hamasharif, M., Joãoa, H., Khan, M., Patel, N., Airley, R. and Day, S. (2014) ‘Azide based routes to tetrazolo and oxadiazolo derivatives of pyrrolobenzodiazepines and pyrrolobenzothiadiazepines’ Tetrahedron , 70 (40), pp. 7306-7317. ISSN 0040-4020 Hemming, K., Jamshaid, F. and Chambers, C. (2014) ‘Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines’ Molecules , 19 (10), pp. 16737-16756. ISSN 1420-3049 Hemming, K (2014) ‘Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines’ Molecules , 19 (10), pp. 16737-16756. ISSN 1420-3049 Ward, R. and Hemming, K. (2014) ‘Ethane-beta-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats’ Alcoholoism and Drug Dependence , 2 (2), p. 150. ISSN 2329-6488 Khan, M., Pitard, A., O'Gorman, P. and Hemming, K. (2013) ‘1,2,4-Oxadiazoles from cycloreversions of oxadiazabicyclo[3.2.0]heptenes: 1-azetines as thiocyanate equivalents’ Tetrahedron , 69 (4), pp. 1279-1284. ISSN 0040-4020 Hemming, K., Kondakal, V. and Qamar, M. (2012) ‘The synthesis of hydroxy-pyrrolizidines and indolizidines from cyclopropenones: towards hyacinthacines, australines and jenamidines’ Tetrahedron Letters , 53 (32), pp. 4100-4103. ISSN 0040-4039 Hemming, K., Kondakal, V. and Qamar, M. (2012) ‘The synthesis of hydroxy-pyrrolizidines and indolizidines from cyclopropenones: towards hyacinthacines, australines and jenamidines’ Tetrahedron Letters , 53 (32), pp. 4100-4130. ISSN 0040-4039 Hemming, K., Khan, M., Kondakal, V., Rice, C., Pitard, A. and Qamar, M. (2012) ‘Pyridines from azabicyclo[3.2.0]hept-2-en-4-ones through a proposed azacyclopentadienone’ Organic Letters , 14 (1), pp. 126-129. ISSN 15237060 Hemming, K (2011) ‘Heterocyclic chemistry’ Annual Reports Section B Organic Chemistry , 107 (1), pp. 118-137. ISSN 0069-3039 Ward, R., Lallemand, F., de Witte, P., Chrichton, R., Piette, J., Tipton, K., Hemming, K., Pitard, A., Page, M., Corte, L., Taylor, D. and Dexter, D. (2011) ‘Anti-inflammatory actions of a taurine analogue - ethane beta-sultam’ Biochemical Pharmacology , 81 (6), pp. 743-751. ISSN 0006-2952 Hemming, K (2010) ‘Heterocyclic Chemistry’ Annual Reports on the Progress of Chemistry Section B , 106, pp. 136-155. ISSN 0069-3030 Hemming, K (2010) ‘Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines’ Tetrahedron Letters , 51 (37), pp. 4859-4861. ISSN 0040-4039 Patel, N., Chambers, C. and Hemming, K. (2009) ‘The synthesis of benzothiadiazines, benzothiadiazepines and benzothiadiazocines from intramolecular azide reactions and iodocyclisations’ Synlett , 2009 (18), pp. 3043-3047. ISSN 09365214 Hemming, K (2009) ‘Heterocyclic chemistry’ Annual Reports Section "B" (Organic Chemistry) , 105, pp. 129-149. ISSN 00693030 O’Gorman, P., Chen, T., Cross, H., Naeem, S., Pitard, A., Qamar, M. and Hemming, K. (2008) ‘A new and simple method for the synthesis of highly functionalised pyrrolizidines, indolizidines and pyrroloazepines’ Tetrahedron Letters , 49 (44), pp. 6316-6319. ISSN 0040-4039 Waters, L., Naz, S. and Hemming, K. (2008) ‘Calorimetric investigations of the hydrolytic degradation for a series of ?-sultams’ Journal of Thermal Analysis and Calorimetry , 93 (2), pp. 339-342. ISSN 14182874 Tsang, W., Ahmed, N., Hemming, K. and Page, M. (2008) ‘An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysis’ The Journal of Organic Chemistry , 73 (12), pp. 4504-4512. ISSN 00223263 Hemming, K (2008) ‘Bicyclic 6-6 systems: five or more heteroatoms’. In: Comprehensive Heterocyclic Chemistry III. London, UK: Elsevier. pp. 1093-1134. ISBN 0-08-044991-3