Belton, Daniel - Huddersfield University - Department of Chemistry and Chemical Engineering

个人简介

Dr Daniel Belton MEng PhD AMIChemE MRSC was appointed as a Lecturer in Analytical Chemistry at Huddersfield in 2008. He was awarded his MEng (hons) in Chemical Engineering from UMIST, which included industrial placements at Jacobs Engineering and BNFL. He then studied for a PhD in Chemical Engineering and Analytical Science with Dr Aline Miller at the University of Manchester. The PhD was sponsored by industry (Avecia and Intertek) and focused on the stability of Protective Antigen, the active ingredient in a new anthrax vaccine. Principal research interests are in biopharmaceutical stability, protein behaviour, smart particles for drug delivery and 2nd generation biofuels. The work encompasses various areas of analytical chemistry including spectroscopy, analytical bioscience and particle characterisation.

研究领域

Protein Behaviour and Biopharmaceutical Stability Aggregation is a major issue with many biopharmaceutical proteins. There is a need to characterise the effect of environmental conditions (temp, pH, ionic strength etc), processing conditions and formulation on stability in order to improve the manufacture of biopharmaceuticals. Key areas of work include: Aggregation: growth rate, kinetics and thermodynamics using light scattering Formulation: testing effect of additives on stability and aggregation Processing: effect of different processing conditions on stability and aggregation Properties: modelling UV absorption coefficient and refractive index from structure Folding: analysis of protein unfolding and refolding using spectroscopic methods Smart Particles for Drug Delivery Effective delivery of therapeutic macromolecules (proteins, DNA etc) is a major challenge. The use of smart particles could greatly enhance the pharmacokinetics of such agents if the particles are able to overcome a number of challenges, such as extended residence time within the body, targeting of cells or tissue and trafficking across cell membranes (i.e. to cross blood-brain barrier or to target DNA to cell nucleus etc).There is a need to optimise properties for both physical stability and biological interaction. Key areas of work include: Synthesis: model systems which combine biological functionality with physical stability Characterisation: physical stability (using analytical techniques) and biological interaction (using biological assays) 2nd Generation Biofuels Climate change and over dependency on oil and gas has led to increased interest in biofuels. The first generation of biofuels have been criticised for competing with food production, high energy demand and use of fertilisers. Second generation biofuels seek to address these issues by utilising waste cellulosic by-products from forestry and agriculture. There are many challenges in converting such materials into useful liquid fuels. One possible route is gasification and catalysis. However, the extreme processing conditions required gives rise to major challenges for catalyst stability and life-time. There is a need to characterise catalyst performance under these conditions and ultimately develop a new generation of more robust catalysts. Key areas of work include: Characterisation: catalyst performance and degradation under normal operating conditions Development: theory guided development using various approaches to improve stability

近期论文

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Belton, D (2016) ‘Teaching process simulation using video-enhanced and discovery/inquiry-based learning: methodology and analysis within a theoretical framework for skill acquisition’ Education for Chemical Engineers , 17, pp. 54-64. ISSN 1749-7728 Almond, M., Belton, D., Humphreys, P. and Laws, A. (2016) ‘A study of the metal binding capacity of saccharinic acids formed during the alkali catalysed decomposition of cellulosic materials: nickel complexation by glucoisosaccharinic acids and xyloisosaccharinic acids’ Carbohydrate Research , 427, pp. 48-54. ISSN 0008-6215 Campbell, G. and Belton, D. (2016) ‘Setting up new chemical engineering degree programmes: Exercises in design and retrofit within constraints’ Education for Chemical Engineers , 17, pp. 1-13. ISSN 1749-7728 Austerberry, J. and Belton, D. (2016) ‘The aggregation of cytochrome C may be linked to its flexibility during refolding’ 3 Biotech , 6 (1). ISSN 2190-572X Knapton, S. and Belton, D. (2015) ‘Active Learning Resources for 'Students as Researchers'’. In: RSC Chemistry Teaching Symposium: Showcase for Student Projects on Chemical Education, 2nd June 2015, York, UK Harling, G. and Belton, D. (2015) ‘Creating an Immersive Learning Experience for Teaching ICP-MS’. In: RSC Chemistry Teaching Symposium: Showcase for Student Projects on Chemical Education, 2nd June 2015, York, UK Torpe, A. and Belton, D. (2015) ‘Improved Spectrophotometric Analysis of Fullerenes C60 and C70 in High-solubility Organic Solvents’ Analytical Sciences , 31 (2), pp. 125-130. ISSN 1348-2246 Bentley, S., Allan, R. and Belton, D. (2014) ‘Flipping the Classroom with Peer Instruction - How Effective Is It?’. In: eLearning 2.0, 23 July 2014, Brunel Business School Belton, D (2014) ‘Experience of Trying Out the Inverted Classroom Approach’. In: ChemEngDayUK 2014, 7th to 8th April 2014, Manchester, UK Bentley, S., Allan, R., Belton, D., Moffat, F., Pufal, D., Balac, P., Hunter, A. and Shaw, N. (2013) ‘Flipping the Classroom with Just in Time Teaching and Peer Instruction: Case Studies from the Sciences and Business’. In: ALT-C 2013, 10-12 September 2013, East Midlands Conference Centre, University of Nottingham Belton, D., Allan, R. and Bentley, S. (2013) ‘Inverting the Classroom for Final year Analytical Chemistry’. In: HEA STEM: Annual Learning and Teaching Conference 2013, 17-18 Apr 2013, University of Birmingham Belton, D. and Miller, A. (2013) ‘Thermal Aggregation of Recombinant Protective Antigen: Aggregate Morphology and Growth Rate’ Journal of Biophysics (751091). ISSN 1687-8000 Taylor, N., Austerberry, J., Laity, P. and Belton, D. (2012) ‘The application of simultaneous electric and magnetic fields to aid protein crystallisation’. In: Nanoformulation 2012, 27th May – 1st June 2012, Barcelona, Spain Fenton, A., Austerberry, J. and Belton, D. (2012) ‘Investigating the mechanisms responsible for and the factors affecting protein aggregation’. In: Nanoformulation 2012, 27th May – 1st June 2012, Barcelona Winter, E., Laity, P. and Belton, D. (2012) ‘Synthesis of internally supported liposomes’. In: Nanoformulation 2012, 27th May – 1st June 2012, Barcelona, Spain Austerberry, J. and Belton, D. (2012) ‘Small Angle Neutron Scattering Studies of Protein Aggregation’. In: Nanoformulation 2012, 27th May – 1st June 2012, Barcelona, Spain Winter, E., Laity, P. and Belton, D. (2012) ‘Characterisation of internally supported liposomes’. In: Nanoformulation 2012, 27th May – 1st June 2012, Barcelona, Spain Austerberry, J., Miller, A. and Belton, D. (2010) ‘Elucidating the mechanism and thermodynamics of protein aggregation in order to create novel biomaterials’. In: Nanoformulation 2010, 9th – 11th June 2010, Stockholm, Sweden Belton, D (2010) ‘Synthesis and characterisation of novel composite nano particles’. In: Nanoformulation 2010, 9th – 11th June 2010, Stockholm, Sweden Belton, D. and Miller, A. (2009) ‘Thermal Aggregation of Protective Antigen Monitored by Light Scattering Spectroscopy’. In: 8th World Congress of Chemical Engineering (WCCE8), 23-27 August 2009, Palais des Congrès de Montréal