Obara, Ilona - Durham University - School of Medicine, Pharmacy & Health, Pharmacy

个人简介

She received an MSc in Biology from the Jagiellonian University, Krakow, Poland (2000) and earned a PhD in Medical Sciences from the Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland (2007). Her doctoral work focused on the contribution of peripheral opioid receptors in opioid-induced analgesia following localised drug administration in both neuropathic and inflammatory pain. In 2004 she trained in the Institute of Biochemistry, Research Group for Peptide Chemistry, Hungarian Academy of Sciences, Seged, Hungary and in the Department of Pharmacology and Pharmacotherapy, Medical Faculty, Semmelweis University, Budapest, Hungary. Here she was awarded a START scholarship from the Foundation for Polish Science (FNP) and The Konorski Award-National Neuroscience Highlight of the Year from the Polish Neuroscience Society. Ilona conducted post-doctoral research at the Department of Psychology at the University of California, Santa Barbara, USA (2007-2009) and Department of Cell and Developmental Biology at the University College London, UK (2009-2012). During her post-doctoral training she worked on the molecular and cellular mechanisms underlying neuroplastic changes induced by nerve/tissue injury in chronic pain. Prior to joining the faculty in the Division of Pharmacy in November 2012 she became interested in the mechanisms of trigeminal neuralgia (School of Biomedical Sciences at the Leeds University).

研究领域

Neuroscience Neuropharmacology Neurobiology Pain Intracellular signalling Opioids

近期论文

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Nazar, H., Obara, I., Paterson, A., Nazar, Z., Portlock, J. & Husband, A. (2016). A journey of undergraduate pharmacy Interprofessional Education: the learning for students and educationalists. American Journal of Pharmaceutical Education Pini, A., Obara, I., Battell, E., Chazot, P.L. & Rosa, A.C. (2016). Histamine in diabetes: is it time to reconsider?. Pharmacological Research 111: 316-324. Mangione, A.S., Obara, I., Maiarú, M., Geranton, S.M. Tassorelli, C., Ferrari, E., Leese, Ch., Davletov, B. & Hunt, S.P. (2016). Nonparalytic botulinum molecules for the control of pain. Pain 157(5): 1045-1055. Obara, I., Medrano, M.C., Signoret-Genest, J., Jiménez-Díaz, L., Géranton, S.M. & Hunt, S.P. (2015). Inhibition of the Mammalian Target of Rapamycin Complex 1 (mTORC1) signaling pathway reduces itch behaviour in mice. Pain 156(8): 1519-1529. Jagla, G., Mika, J., Makuch, W., Obara, I., Wordliczek, J. & Przewlocka, B. (2014). Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain. Pharmacological Reports 66(3): 459-465. Obara, I. & Hunt, S.P. (2014). Axonal protein synthesis and the regulation of primary afferent function. Developmental Neurobiology 74(3): 269-278. Obara, I., Goulding, S.P., Gould, A.T., Lominac, K.D., Hu, J.H., Zhang, P.W., von Jonquieres, G., Dehoff, M., Xiao, B., Seeburg, P.H., Worley, P.F., Klugmann, M. & Szumlinski, K.K. (2013). Homers at the Interface between Reward and Pain. Frontiers in Psychiatry 4(39). Obara, I., Goulding, S.P., Hu, J.H., Klugmann, M., Worley, P.F. & Szumlinski, K.K. (2013). Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain. Pain 154(10): 1932-1945. Ferrari, E., Gu, C., Niranjan, D., Restani, L., Rasetti-Escargueil, C., Obara, I., Geranton, S.M., Arsenault, J., Goetze, T.A., Harper, C.B., Nguyen, T.H., Maywood, E., O'Brien, J., Schiavo, G., Wheeler, D.W., Meunier, F.A., Hastings, M., Edwardson, J.M., Sesardic, D., Caleo, M., Hunt, S.P. & Davletov, B. (2013). Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjugate Chemistry 24(10): 1750-1759. Obara, I., Géranton, S.M. & Hunt, S.P. (2012). Axonal protein synthesis: a potential target for pain relief?. Current Opinion in Pharmacology 12(1): 42-48. Goulding, SP, Obara, I, Lominac, KD, Gould, AT, Miller, BW, Klugmann, M & Szumlinski, KK (2011). Accumbens Homer2mediated signalling: a factor contributing to mouse strain differences in alcohol drinking?. "Genes, Brain and Behavior" Obara, I, Tochiki, KK, Geranton, SM, Carr, FB, Lumb, B, Liu, Q & Hunt, SP (2011). Systemic inhibition of the mammalian target of rapamycin (mTOR) pathway reduces neuropathic pain in mice. Pain 152(11): 2582-2595. Mika, J, Obara, I & Przewlocka, B (2011). The role of nociceptin and dynorphin in chronic pain: Implications of neuro-glial interaction. Neuropeptides 45(4): 247-261. Obara, I, Gunduz Cinar, O, Starowicz, K, Benyhe, S, Borsodi, A & Przewlocka, B (2010). Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats. Journal of Neural Transmission 117(4): 421-429. Marinelli, S, Luvisetto, S, Cobianchi, S, Makuch, W, Obara, I, Mezzaroma, E, Caruso, M, Straface, E, Przewlocka, B & Pavone, F (2010). Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models. Neuroscience 171(1): 316-328. Cozzoli, DK, Goulding, SP, Zhang, PW, Xiao, B, Hu, JH, Ary, AW, Obara, I, Rahn, A, Abou-Ziab, H, Tyrrel, B, Marini, C, Yoneyama, N, Metten, P, Snelling, C, Dehoff, MH, Crabbe, JC, Finn, DA, Klugmann, M, Worley, PF, & Szumlinski, KK (2009). Binge drinking upregulates accumbens mGluR5-Homer2-P13K signaling: functional implications for alcoholism. Journal of Neuroscience 29(27): 8655-8668. Obara, I, Bell, RL, Goulding, SP, Reyes, CM, Larson, LA, Ary, AW, Truitt, WA & Szumlinski, KK (2009). Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcoholism: Clinical and Experimental Research 33(11): 1924-1934. Wrzosek, A, Obara, I, Wordliczek, J & Przewlocka, B (2009). Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis. Journal of Physiology and Pharmacology 60(4): 71-78. Ben-Shahar, O, Obara, I, Ary, AW, Ma, N, Mangiardi, MA, Medina, RL & Szumlinski, KK (2009). Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse 63(7): 598-609. Obara, I, Parkitna, JR, Korostynski, M, Makuch, W, Kaminska, B, Przewlocka, B & Przewlocki, R (2009). Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain. Pain 141(3): 283-291.