Moghimi, Moein - Durham University - School of Medicine, Pharmacy & Health, Pharmacy

研究领域

Nanoparticle engineering for medicine Systems approaches to site-specific targeting and controlled drug delivery and release Nucleic acid therapeutics Mechanistic aspects of injection-related adverse reactions to nanopharmaceuticals & nanomedicine "Structure-activity" cascade and real-time medium-throughput integrated approaches for determination of nanopharmaceutical performance at cell and molecular levels Mechanistic aspects of integrated efficacy-safety profiling of nanopharmaceuticals Experimental T-cell therapies

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Wibroe, P.P., Ahmadvand, D., Oghabianc, M.A., Yaghmur, A. & Moghimi, S.M. (2016). An integrated assessment of morphology, size, and complement activation of the PEGylated liposomal doxorubicin products Doxil?, Caelyx?, DOXOrubicin, and SinaDoxosome. Journal of Controlled Release 221: 1-8. Moghimi, S.M., Hunter, A.C. & Peer, D. (2016). Platelet mimicry: The emperor's new clothes?. Nanomedicine: Nanotechnology, Biology and Medicine 12(1): 245-248. Wibroe, P.P., Petersen, S.V., Bovet, N., Laursen, B.W. & Moghimi, S.M. (2016). Soluble and immobilized graphene oxide activates complement system differently dependent on surface oxidation state. Biomaterials 78: 20-26. Moghimi, S.M., Wibroe, P.P., Wu, L. & Farhangrazi, Z.S. (2015). Insidious pathogen-mimicking properties of nanoparticles in triggering the lectin pathway of the complement system. European Journal of Nanomedicine 7(3): 263-268. Inturi, S., Wang, G., Chen, F., Banda, N.K., Holers, V.M., Wu, L., Moghimi, S.M. & Simbery, D. (2015). Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS Nano 9(11): 10758-10768. Hall, A., Parhamifar, L., Lange, M.K., Meyle, K.D., Sanderhoff, M., Andersen, H., Roursgaard, M., Larsen, A.K., Jensen, P.B., Christensen, C., Bartek, J. & Moghimi, S.M. (2015). Polyethylenimine architecture-dependent metabolic imprints and perturbation of cellular redox homeostasis. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1847(3): 328-342. Jamnani, FR, Rahbarizadeh, F, Shokrgozar, MA, Mahboudi, F, Ahmadvand D, Sharifzadeh, Z, Parhamifar, L & Moghimi, SM (2014). T cells expressing VHH-directed oligoclonal chimeric HER2 antigen receptors: Towards tumor-directed oligoclonal T cell therapy. Biochimica et Biophysica Acta (BBA) - General Subjects 1840(1): 378-386. Andersen, AJ, Robinson, JT, Dai, H, Hunter, AC, Andresen, TL & Moghimi, SM (2013). Single-Walled Carbon Nanotube Surface Control of Complement Recognition and Activation. ACS Nano 7(2): 1108-1119. Moghimi, SM, Hunter, AC & Andresen, TL (2012). Factors Controlling Nanoparticle Pharmacokinetics: An Integrated Analysis and Perspective. Annual Review of Pharmacology and Toxicology 52(1): 481-503. Moghimi, SM, Wibroe, PP, Helvig, SY, Farhangrazi, ZS & Hunter, AC (2012). Genomic perspectives in inter-individual adverse responses following nanomedicine administration: The way forward. Advanced Drug Delivery Reviews 64(13): 1385-1393. Brambilla, D, Verpillot, R, Le Droumaguet, B, Nicolas, J, Taverna, M, Kona J, Lettiero, B, Hashemi, SH, De Kimpe, L, Canovi, M, Gobbi, M, Nicolas, V, Scheper, W, Moghimi, SM, Tvaro?ka, I, Couvreur, P & Andrieuz, K (2012). PEGylated Nanoparticles Bind to and Alter Amyloid-Beta Peptide Conformation: Toward Engineering of Functional Nanomedicines for Alzheimer’s Disease. ACS Nano 6(7): 5897-5908. Moghimi, SM, Peer, D & Langer, R (2011). Reshaping the Future of Nanopharmaceuticals: Ad Iudicium. ACS Nano 5(11): 8454-8458. Moghimi, SM & Hunter, AC (2010). Complement monitoring of carbon nanotubes. Nature Nanotechnology 5(6): 382-383. Hamad, I, Al-Hanbali, O, Hunter, AC, Rutt, KJ, Andresen, TL & Moghimi, SM (2010). Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere?Serum Interface: Implications for Stealth Nanoparticle Engineering. ACS Nano 4(11): 6629-6638. Hamad, I, Hunter, AC, Szebeni, J & Moghimi, SM (2008). Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process. Molecular Immunology 46(2): 225-232. Mukhopadhyay, R, Al-Hanbali, O, Pillai, S, Hemmersam, AG, Meyer, RL, Hunter, AC, Rutt, KJ, Besenbacher, F, Moghimi, SM & Kingshott, P (2007). Ordering of Binary Polymeric Nanoparticles on Hydrophobic Surfaces Assembled from Low Volume Fraction Dispersions. Journal of the American Chemical Society 129(44): 13390-13391. Moghimi, SM, Hamad, I, Andresen, TL, J?rgensen, K & Szebeni, J (2006). Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production. The FASEB Journal 20(14): 2591-2593. Moghimi, SM, Symonds, P, Murray, JC, Hunter, AC, Debska, G & Szewczyk, A (2005). A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Molecular Therapy 11(6): 990-995. Moghimi, SM, Hunter, AC & Murray, JC (2005). Nanomedicine: current status and future prospects. The FASEB Journal 19(3): 311-330. Moghimi, SM, Hunter, AC, Murray, JC & Szewczyk, A (2004). Cellular Distribution of Nonionic Micelles. Science 303(5658): 626-627. Moghimi, SM & Szebeni, J (2003). Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Progress in Lipid Research 42(6): 463-478. Moghimi, SM, Hunter, AC & Murray, JC (2001). Long-Circulating and Target-Specific Nanoparticles: Theory to Practice. Pharmacological Reviews 53(2): 283-318.