Brown, Alistair - Durham University - School of Medicine, Pharmacy & Health, Pharmacy

个人简介

Alistair Brown carried out his PhD studies under the supervision of Prof. Gurdyal Besra at Newcastle University (2000-2004). His work primarily focused on fatty acid biosynthesis in Mycobacterium tuberculosis, the causative organism of TB. He continued to work with Prof. Besra as a BBSRC funded Post-Doctoral Research associate at University of Birmingham, UK (2004-2009). His work concentrated on identification and characterisation of novel drug targets in M. tuberculosis through crystallographic and biochemical analysis. Alistair joined Northumbria University in 2009 after accepting a lectureship in microbiology

研究领域

The biology of Mycobacterium tuberculosis Molecular biology Lipid biochemistry Bacteriology Antimicrobial discovery

近期论文

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Bhakta, S., Scalacci, N., Maitra, A., Brown, A. K., Dasugari, S., Evangelopoulos, D., McHugh, T. D., Mortazavi, P. N., Twist, A., Petricci, E., Manetti, F. & Castagnolo, D. (2016). Design and Synthesis of 1-(1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N′-(E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria. Journal of Medicinal Chemistry 59(6): 2780-2793. Winther, K. S., Brodersen, D. E., Brown, A. K. & Gerdes, K. (2013). VapC20 of Mycobacterium tuberculosis cleaves the sarcin-ricin loop of 23S rRNA. Nature Communications 4: 2796. Taylor, R.C., Brown, A.K., Singh, A., Bhatt, A. & Besra, G.S. (2010). Characterization of a beta-hydroxybutyryl-CoA dehydrogenase from Mycobacterium tuberculosis. Microbiology 156: 1975-1982. Sutcliffe, L.C., Brown, A.K. & Dover, L.G. (2010). The Rhodococcal Cell Envelope: Composition, Organisation and Biosynthesis. Microbiol Monogr 16: 29-71. Al-Balas, Q., Anthony, N.G., Al-Jaidi, B., Alnimr, A., Abbott, G., Brown, A.K., Taylor, R.C., Besra, G.S., McHugh, T.D., Gillespie, S.H., Johnston, B.F., Mackay, S.P. & Coxon, G.D. (2009). Identification of 2-aminothiazole-4-carboxylate derivatives active against Mycobacterium tuberculosis H37Rv and the beta-ketoacyl-ACP synthase mtFabH. PloS one 4: e5617. Brown, A.K., Taylor, R.C., Bhatt, A., Futterer, K. & Besra, G.S. (2009). Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases. PloS one 4: e6306. Veyron-Churlet, R., Molle, V., Taylor, R.C., Brown, A.K., Besra, G.S., Zanella-Cleon, I., Futterer, K. & Kremer, L. (2009). The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue. The Journal of biological chemistry 284: 6414-6424. Dover, L.G., Alderwick, L., Bhowruth, V., Brown, A.K., Kremer, L. & Besra, G.S. (2008). Antibiotics and New Inhibitors of the Cell Wall. Mycobacterial Cell Envelope 107-131. Mishra, K.C., de Chastellier, C., Narayana, Y., Bifani, P., Brown, A.K., Besra, G.S., Katoch, V.M., Joshi, B., Balaji, K.N. & Kremer, L. (2008). Functional role of the PE domain and immunogenicity of the Mycobacterium tuberculosis triacylglycerol hydrolase LipY. Infection and immunity 76: 127-140. Bhatt, A., Brown, A.K., Singh, A., Minnikin, D.E. & Besra, G.S. (2008). Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones. Chemistry & biology 15: 930-939. Bhowruth, V., Brown, A.K. & Besra, G.S. (2008). Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636. Microbiology 154: 1866-1875. Bhowruth, V., Alderwick, L.J., Brown, A.K., Bhatt, A. & Besra, G.S. (2008). Tuberculosis: a balanced diet of lipids and carbohydrates. Biochem Soc T 36: 555-565. Brown, A.K., Meng, G., Ghadbane, H., Scott, D.J., Dover, L.G., Nigou, J., Besra, G.S. & Futterer, K. (2007). Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+. BMC structural biology 7: 55. Brown, A.K., Papaemmanouil, A., Bhowruth, V., Bhatt, A., Dover, L.G. & Besra, G.S. (2007). Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II. Microbiology 153: 3314-3322. Brown, A.K., Bhatt, A., Singh, A., Saparia, E., Evans, A.F. & Besra, G.S. (2007). Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex. Microbiology 153: 4166-4173. Dover, L.G., Alderwick, L.J., Brown, A.K., Futterer, K. & Besra, G.S. (2007). Regulation of cell wall synthesis and growth. Current molecular medicine 7: 247-276. Ghadbane, H., Brown, A.K., Kremer, L., Besra, G.S. & Futterer, K. (2007). Structure of Mycobacterium tuberculosis mtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT). Acta crystallographica Section F, Structural biology and crystallization communications 63: 831-835. Bhowruth, V., Brown, A.K., Senior, S.J., Snaith, J.S. & Besra, G.S. (2007). Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library. Bioorganic & medicinal chemistry letters 17: 5643-5646. Sridharan, S., Wang, L., Brown, A.K., Dover, L.G., Kremer, L., Besra, G.S. & Sacchettini, J.C. (2007). X-ray crystal structure of Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase II (mtKasB). Journal of molecular biology 366: 469-480. Bhowruth, V., Brown, A.K., Reynolds, R.C., Coxon, G.D., Mackay, S.P., Minnikin, D.E. & Besra, G.S. (2006). Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 16: 4743-4747. Molle, V., Brown, A.K., Besra, G.S., Cozzone, A.J. & Kremer, L. (2006). The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. The Journal of biological chemistry 281: 30094-30103. Brown, A.K., Sridharan, S., Kremer, L., Lindenberg, S., Dover, L.G., Sacchettini, J.C. & Besra, G.S. (2005). Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity. The Journal of biological chemistry 280: 32539-32547. Radmacher, E., Alderwick, L.J., Besra, G.S., Brown, A.K., Gibson, K.J., Sahm, H. & Eggeling, L. (2005). Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum. Microbiology 151: 2421-2427. Gande, R., Gibson, K.J., Brown, A.K., Krumbach, K., Dover, L.G., Sahm, H., Shioyama, S., Oikawa, T., Besra, G.S. & Eggeling, L. (2004). Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis. The Journal of biological chemistry 279: 44847-44857. Kremer, L., Dover, L.G., Carrere, S., Nampoothiri, K.M., Lesjean, S., Brown, A.K., Brennan, P.J., Minnikin, D.E., Locht, C. & Besra, G.S. (2002). Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis. The Biochemical journal 364: 423-430.