Bown (née Kinnunen), Hanne - Durham University - School of Medicine, Pharmacy & Health, Pharmacy

个人简介

Hanne completed her MSc in chemistry with minors in biochemistry and physics at the University of Joensuu, Finland, in December 2005. Subsequently she spent half a year at the Department of Chemistry at the University of Warwick as a Marie Curie visiting researcher studying non-covalent protein-ligand interactions using ESI-FTICR mass spectrometry. In September 2006 she started working in the applications laboratory of Malvern Instruments at the company’s UK headquarter. During her time at Malvern she gained knowledge in particle sizing and morphological analysis of powders, including active pharmaceutical ingredients and excipients. Her time at Malvern inspired her to pursue a PhD in pharmaceutics, and consequentially in February 2009 she started a PhD project at the University of Bath under the supervision of Professor Robert Price. During her PhD she studied how the bulk properties of lactose that is used as an excipient in dry powder inhaler formulations govern the final formulation performance

研究领域

Drug delivery Biotherapeutics Formulation Particle engineering

近期论文

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Kinnunen, Hanne M., Sharma, Vikas, Contreras-Rojas, Luis Rodrigo, Yu, Yafei, Alleman, Chl?e, Sreedhara, Alavattam, Fischer, Stefan, Khawli, Leslie, Yohe, Stefan T., Bumbaca, Daniela, Patapoff, Thomas W., Daugherty, Ann L. & Mrsny, Randall J. (2015). A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components. Journal of Controlled Release 214: 94-102. Kinnunen, H, Hebbink, G, Peters, H, Huck, D, Makein, L & Price, R (2015). Extrinsic lactose fines improve dry powder inhaler formulation performance of a cohesive batch of budesonide via agglomerate formation and consequential co-deposition. International Journal of Pharmaceutics 478(1): 53-59. Kinnunen, H, Hebbink, G, Peters, H, Shur, J & Price, R (2014). An investigation into the effect of fine lactose particles on the fluidization behaviour and aerosolization performance of carrier-based dry powder inhaler formulations. AAPS PharmSciTech 15(4): 898-909. Kinnunen, H, Hebbink, G, Peters, H, Shur, J & Price, R (2014). Defining the critical material attributes of lactose monohydrate in carrier based dry powder inhaler formulations using artificial neural networks. AAPS PharmSciTech 15(4): 1009-1020. Kinnunen, H.M & Mrsny, R.J (2014). Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site. Journal of Controlled Release 182: 22-32. Kinnunen, H, Shur, J, Hebbink, G, Muresan, A.S & Price, R (2010). Lactose fluidisation properties and their relationship to dry powder inhaler performance. Journal of Pharmacy and Pharmacology 62(10): 1342-1343. Marjasvaara, A, Torvinen, M, Kinnunen, H & Vainiotalo, P (2006). Laccase-catalyzed polymerization of two phenolic compounds studied by matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry with collision-induced dissociation experiments. Biomacromolecules 75(5): 1604-1609.