Cobb, Steven - Durham University - Department of Chemistry

个人简介

Steven Cobb carried out his PhD with Professor David O’Hagan at St. Andrews University (2001-2005). His work focused on the biosynthesis of fluorinated natural products, in the bacteria Streptomyces cattleya. The highlight of this research was the identification of the first ever naturally-occurring C-F bond forming enzyme (Nature, 2002, 416, 279). Steven was awarded an Alberta Heritage Foundation for Medical Research Fellowship and moved to the University of Alberta, to work with Professor John Vederas, FRS. During this time he was introduced to the field of peptide chemistry and he worked on the development of new peptide based antibiotics. In October 2007 Steven moved to the Chemistry Department at Durham University as a temporary lecturer, and from this position he was awarded a prestigious Ramsay Memorial Trust Research Fellowship (2008–2010). In 2010 he was appointed to the position of Lecturer and since then he has attracted research funding from various competitive sources as a PI including the Royal Society, the EPSRC, The Wellcome Trust, The Leverhulme Trust, UK industry and he was recently the successful PI on a Bill and Melinda Gates Foundation Grant (one of only 100 grants award worldwide from over 2100 applications)

研究领域

Peptide Drug Design and Delivery Peptidomimetics Bioorganic Fluorine Chemistry

近期论文

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Li H., Chadbourne FL, Lan R., Chi-Fai Chan, Wai-Lun Chan W-L, Law G-L,* Chi-Sing Lee,* Cobb SL, and Wong K-L*Structural and functional analysis of lanthanide bioprobes for europium signaling changes in different Cyclin A concentrations on living tumor cells. 2013, Dalton Trans. DOI: 10.1039/C3DT51053K Hudson AS., Hoose A, Coxon CR.,Sandford G. and Cobb SL, Synthesis of a novel tetrafluoropyridine containing amino acid and tripeptide. Tetrahedron Lett. 2013, 54(36), 4865-4867 Saleki M, Colgin N, Kirby JA, Cobb SL and Ali S. Evaluation of two cyclic di-peptides as inhibitors of CCL2 induced chemotaxis. Med. Chem. Comm., 2013, 4, 860-864 Colgin N, Tatum NJ, Pohl E, Cobb SL, G. Sandford. Synthesis and molecular structure of a perfluorinated pyridyl carbanion. J. Fluorine Chem. 2012, 133, 33-37 Colgin N, Flinn T, Cobb SL. Synthesis and properties of MIDA boronate containing aromatic amino acids: New peptide building blocks. Org. Biomol. Chem. 2011, 9, 1864 – 1870. Kong HK, Chadbourne FL, Law GL, Ko CYT, Tam HL, Cobb SL, Lau CK, Lee CS, Wong KL. Two-Photon Induced Responsive f-f Emissive Detection for Cyclin A with Europium-Chelating Peptide. Chem. Commun., 2011, 47, 8052-8054. Chadbourne FL, Raleigh C, Ali HZ, Denny PW, Cobb SL, Studies on the antileishmanial properties of the antimicrobial peptides Temporin A, B and 1Sa. J. Pept. Sci. 2011, 17, 751-755