Sharples, Gary - Durham University - School of Biological and Biomedical Science

研究领域

Bacteriophage genome rearrangements Evolution of bacterial pathogenicity Horizontal gene transfer Mechanisms of homologous recombination Antimicrobial surfaces and peptides

近期论文

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Eissa, A.M., Abdulkarim, A., Sharples, G.J. & Cameron, N.R. (2016). Glycosylated nanoparticles as efficient antimicrobial delivery agents. Biomacromolecules 17(8): 2672-2679. Nautiyal, A., Rani, P.S., Sharples, G.J. & Muniyappa, K. (2016). Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain. Molecular Microbiology 100(4): 656-674. Joubert, Fanny, Yeo, R. Paul, Sharples, Gary J., Musa, Osama M., Hodgson, David R. W. & Cameron, Neil R. (2015). Preparation of an antibacterial poly(ionic liquid) graft copolymer of hydroxyethyl cellulose. Biomacromolecules 16(12): 3970-3979. Joubert, Fanny, Sharples, Gary J., Musa, Osama M., Hodgson, David R. W. & Cameron, Neil R. (2015). Preparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups. Journal of Polymer Science Part A: Polymer Chemistry 53(1): 68-78. Fenyk, Stepan, Townsend, Philip D., Dixon, Christopher H., Spies, Gerhard B., de San Eustaquio Campillo, Alba, Slootweg, Erik J., Westerhof, Lotte B., Gawehns, Fleur K.K., Knight, Marc R., Sharples, Gary J., Goverse, Aska, P?lsson, Lars-Olof, Takken, Frank L.W. & Cann, Martin J. (2015). The Potato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor Rx1 is a Pathogen Dependent DNA-Deforming Protein. Journal of Biological Chemistry 290(41): 24945-24960. Curtis, F.A., Malay, A.D., Trotter, A.J., Wilson, L.A., Barradell-Black, M.M., Bowers, L.Y., Reed, P., Hillyar, C.R.T., Yeo, R.P., Sanderson, J.M., Heddle, J.G. & Sharples, G.J. (2014). Phage Orf family recombinases: conservation of activities and involvement of the central channel in DNA binding. PLoS One 9(8): e102454. Green, V., Curtis, F.A., Sedelnikova, S., Rafferty, J.B. & Sharples, G. (2013). Mutants of phage bIL67 RuvC with enhanced Holliday junction binding selectivity and resolution symmetry. Molecular Microbiology 89(6): 1240–1258. Matsubara, K., Malay, A.D., Curtis, F.A., Sharples, G.J. & Heddle, J.G. (2013). Structural and functional characterization of the Redβ recombinase from bacteriophage λ. PLOS ONE 8(11): e78869. Wood, T.J., Hurst, G.A., Schofield, W.C.E., Thompson, R.L., Oswald, G., Evans, J.S.O., Sharples, G.J., Pearson, C., Petty, M.C. & Badyal, J.P.S. (2012). Electroless deposition of multi-functional zinc oxide surfaces displaying photoconductive, superhydrophobic, photowetting, and antibacterial properties. Journal of Materials Chemistry 22(9): 3859-3867. Curtis F.A., Reed, P., Wilson, L.A., Bowers, L.Y., Yeo, P., Sanderson, J.M., Walmsley, A.R. & Sharples, G.J. (2011). The C-terminus of the phage lambda Orf recombinase is involved in DNA binding. Journal of Molecular Recognition 24(2): 330-340. Sharples, G.J. (2009). For absent friends: life without recombination in mutualistic gamma-proteobacteria. Trends in Microbiology 17(6): 233-242. Carrasco, B., Ca?as, C., Sharples, G.J., Alonso, J.C. & Ayora, S. (2009). The N-terminal region of the RecU Holliday junction resolvase is essential for homologous recombination. Journal of Molecular Biology 390(1): 1-9. Pan, P.-S., Curtis, F.A., Carroll, C.L., Medina, I., Rodrigeuz, R., Liotta, L.A., Sharples, G.J. & McAlpine, S.R. (2006). Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorg Med Chem 14: 4731-4739. Wen, Q., Mahdi, A.A., Briggs, G.S., Sharples, G.J. & Lloyd, R.G. (2005). Conservation of RecG activity from pathogens to hyperthermophiles. DNA Repair 4: 23-31. Curtis, F.A., Reed, P. & Sharples, G.J. (2005). Evolution of a phage RuvC endonuclease for resolution of both Holliday and branched DNA junctions. Molecular Microbiology 55(5): 1332-1345. Maxwell, K. L., Reed, P., Zhang, R. G., Beasley, S., Walmsley, A. R., Curtis, F. A., Joachimiak, A., Edwards, A. M. & Sharples, G. J. (2005). Functional similarities between phage lambda Orf and Escherichia coli RecFOR in initiation of genetic exchange. Proceedings of the National Academy of Sciences of the United States of America 102(32): 11260-11265. Sanchez, H., Kidane, D., Reed, P., Curtis, F.A., Cozar, M.C., Graumann, P.L., Sharples, G.J. & Alonso, J.C. (2005). The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis. Genetics 171: 873-883. Borges-Walmsley, M.I., Du, D., McKeegan, K.S., Sharples, G.J. & Walmsley, A.R. (2005). VceR regulates the vceCAB drug efflux pump operon of Vibrio cholerae by alternating between mutually exclusive conformations that bind either drugs or promoter DNA. Journal of Molecular Biology 349(2): 387-400. Moore, T., Sharples, G.J. & Lloyd, R.G. (2004). DNA binding by the meningococcal RdgC protein associated with pilin antigenic variation. Journal of Bacteriology 186: 870-874. Sharples, G. J., Curtis, F. A., McGlynn, P. & Bolt, E. L. (2004). Holliday Junction Binding and Resolution by the Rap Structure-specific Endonuclease of Phage lambda. Journal of Molecular Biology 340(4): 739-751.