个人简介
王慧君，主任法医师，现任南方医科大学法医学院首席科学家，广东省司法鉴定协会会长。
从零起步，牵头建立和建设了南方医科大学法医学学科，完成了从教研室到法医学系再到法医学院的建立和建设，完成了我校从法医学专业本科生招生，硕士、博士点建立、招生，到博士后联合培养基地完整的法医学教育体系建设，为我国输送高层次法医人才。近年来共获科研基金二十余项，主持16项，含国家自然科学基金7项（其中重点项目1项），科研经费共计约750多万元。发表研究论文百余篇，其中SCI论文28篇，最高影响因子34.833（《新英格兰医学杂志》），出版专著10部。
牵头建立和建设的南方医科大学司法鉴定中心、交通事故司法鉴定技术研究所，面向社会提供高科技司法鉴定服务，每年承接万余例案件和事件的鉴定，产生了巨大的社会效益和经济效益，较好地发挥了高等院校科技力量服务社会的职能，在技生产力转化为经济效益和社会效益中发挥了重要作用。
曾获中华医学科技奖一等奖一项（排名第四），军队科技进步二等奖一项（排名第二），获中国人民解放军总后勤部育才奖银，荣立三等功一次。获司法部 “法律服务主题实践活动”先进个人、广东省精神文明建设先进个人、广州市抗击非典先进个人、南粤优秀教师、南医优秀教师、南医十佳导师等称号。
科研项目：
国家自然科学基金面上项目，81871528， METH激活胶质细胞经NF-κB-LCN2/焦亡通路致脑神经毒性损伤作用机制研究，2019.01-2022.12,57万，在研，主持
广州市科技计划项目，201803010005,C/EBPβ在METH导致的主动脉夹层中的作用机制，2018.04.01-2021.03.31,100万，在研，主持
国家自然科学基金重点项目,81430045,内质网应激在甲基苯丙胺诱导的神经毒性中的作用及分子病理机制, 2015.01-2019.12,320万，在研，主持
广东省研究生教育创新计划,GSTP1-P35/P25-CDK5信号轴介导的甲基苯丙胺神经毒性机制, 2014.01-2016.01,6万，已结题，主持
国家科技支撑计划项目子课题,虚拟解剖、数字化构模及生物力学响应研究, 2013.01-2013.12,21万，已结题，主持
国家自然科学基金, 81273345,NO相关氧化应激新通路在甲基苯丙胺致心脑毒性损伤机制中的研究, 2013.01-2016.12,70万，已结题，主持
上海市科委KF0906,冠心病猝死的代谢组学研究, 2009.01-2012.12, 5万，已结题，主持
国家自然科学基金面上,30872918,DDAH/ADMA/NOS系统及其相关靶蛋白在甲基苯丙胺精神毒性中作用机制研究, 2009.01-2011.12,30万，已结题，主持
国家自然科学基金委面上,30572090,甲基苯丙胺对中枢神经系统毒性作用和药物成隐性形成机理的研究, 2006.01-2008.12,27万，已结题，主持
广东省科委,2004B33801008,甲基苯丙胺（冰毒）对中枢神经系统毒性作用及药物成隐性机理的研究, 2004.12-2007.12,13万，已结题，主持
国家自然科学基金,30370588,iNOS过表达导致心肌炎猝死的分子机制研究, 2004.01-2006.12,7万，已结题，主持
总后军队专项基金,03F0 16-2,非典型性肺炎病理学及发病机制的研究, 2003.03-2003.12,30万，已结题，主持
第一军医大学博士后人员启动基金,010517，205号,巨噬细胞及其因子表达与损伤和修复时间关系的研究, 2001.04-2004.04,3万，已结题，主持
广东省科委科研功关,2KM05404S,法医学鉴定新技术——损伤时间推断参考标准的研究, 2001.01-2003.12,10万，已结题，主持
广东省科委科研功关,99B06703G,颅脑损伤的生物力学研究（创伤救治技术与器材开发）, 2001.09-2002.09,2万，已结题，主持
国家自然科学基金委员会, 39870764,创伤修复早期的细胞学和分子生物学变化与损伤时间的关系, 1999.01-2001.12,11万，已结题，主持
近期论文
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Wei-Qi Hao,Jing Liu,Li Jiang,Jun-Ping Han,Ling Wang,Jiu-Ling Li,Quan Ma,Chao Liu, Huijun Wang*,Cai-Xia Li,Exploring the ancestry differentiation and inference capacityof the 28-plex AISNPs,International Journal of Legal Medicine,07 June 2018 (IF:2.382）
Ning, X., Fu, Z., Zhu, B., Chao, L., Lin, Z., &Huijun Wang*, et al. Cdk5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. 2018. 2018 Apr 26 (IF:3.86）
Lizeng Li, Si Chen, Yue Wang,Xia Yue,Jingtao Xu,Weibing Xie,Pingming Qiu,Chao Liu,AiFeng Wang*and Huijun Wang*,Role of GSK3β/α-synuclein axis inmethamphetamine-induced neurotoxicity inPC12 cells,Toxicol. Res., 2017 Dec 22;7(2):221-234(IF:1.89）
Si-Hao Du, Dong-Fang Qiao, Chuan-Xiang Chen, Si Chen, Chao Liu, Zhoumeng Lin, Huijun Wang*, Weibing Xie,Toll-like receptor 4 mediates methamphetamine-induced neuroinflammation through Caspase-11 signaling pathway in astrocytes. Front Mol Neurosci. 2017 Dec 12;10:409. (IF:3.902）
Xiang Xu, Enping Huang, Yunchun Tai, Xu Zhao, Xuebing Chen, Chuanxiang Chen, Rui Chen, Chao Liu, Zhoumeng Lin, Huijun Wang*, Weibing Xie. Nupr1 modulates methamphetamine-induced dopaminergic neuronal apoptosis and autophagy through CHOP-Trib3-mediated endoplasmic reticulum stress signaling pathway. Front Mol Neurosci. 2017 Jun 26;10:203 (IF:3.902）
Cai D, Huang E, Luo B, Yang Y, Zhang F, Liu C, Lin Z, Xie WB, Huijun Wang*.Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cell Death Dis. 2016 Mar 31;7:e2161. （IF 5.965）
Chen R, Wang B, Chen L, Cai D, Li B, Chen C, Huang E, Liu C, Lin Z, Xie WB, Huijun Wang*.DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes. Toxicol Appl Pharmacol. 2016 Mar 15;295:1-11（IF 3.847）
Li B, Chen R, Chen L, Qiu P, Ai X, Huang E, Huang W, Chen C, Liu C, Lin Z, Xie WB, Huijun Wang*. Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons. Mol Neurobiol. 2017 Apr;54(3):1642-1660.（IF 6.19）
Chen C, Qincao L, Xu J, Du S, Huang E, Liu C, Lin Z, Xie WB, Huijun Wang*.Role of PUMA in methamphetamine-induced neuronal apoptosis. Toxicol Lett. 2016 Jan 5;240(1):149-60.（IF 3.522）
Huang W, Xie WB, Qiao D, Qiu P, Huang E, Li B, Chen C, Liu C, Wang Q, Lin Z, Huijun Wang*. Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Sci. 2015 May;145(1):68-79. (IF:4.478)
Tai Y, Chen L, Huang E, Liu C, Yang X, Qiu P, Huijun Wang*. Protective effect of alpha-synuclein knockdown on methamphetamine-induced neurotoxicity in dopaminergic neurons. Neural Regen Res. 2014 May 1;9(9):951-8. (IF:0.234)
Wang J, Zou D, Li Z, Huang P, Li D, Shao Y, Huijun Wang*, Chen Y. Mechanical properties of cranial bones and sutures in 1-2-year-old infants. Med Sci Monit. 2014 Oct 3;20:1808-13. (IF:1.216)
Leung KP, Qu YH, Qiao DF, Xie WB, Li DR, Xu JT, Huijun Wang*, Yue X. Critical role of insulin‑like growth factor binding protein‑5 in methamphetamine‑induced apoptosis in cardiomyocytes. Mol Med Rep. 2014 Nov;10(5):2306-12 (IF: 1.484)
Wu XF, Wang AF, Chen L, Huang EP, Xie WB, Liu C, Huang WY, Chen CX, Qiu PM, Huijun Wang*.S-Nitrosylating protein disulphide isomerase mediates α-synuclein aggregation caused by methamphetamine exposure in PC12 cells. Toxicol Lett. 2014 Oct 1;230(1):19-27. (IF:3.355)
Qiao D, Xu J, Le C, Huang E, Liu C, Qiu P, Lin Z, Xie WB, Huijun Wang*. Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis. Toxicol Lett. 2014 Nov 4;230(3):444-53. (IF:3.355)
Qu YH, Leung KP, Qiao DF, Li DR, Liu C, Yue X, Huijun Wang*. Remodeling of ion channel expression may contribute to electrophysiological consequences caused by methamphetamine in vitro and in vivo. Biochem Biophys Res Commun. 2014 Jan 10;443(2):441-6. (IF:2.281)
Yang X, Liu Y, Liu C, Xie W, Huang E, Huang W, Wang J, Chen L, Wang H, Qiu P, Xu J, Zhang F, Huijun Wang*.. Inhibition of ROCK2 expression protects against methamphetamine-induced neurotoxicity in PC12 cells. Brain Res. 2013 Oct 2;1533:16-25. (IF: 2.879)
Zhang F, Chen L, Liu C, Qiu P, Wang A, Li L, Huijun Wang*. Up-regulation of protein tyrosine nitration in methamphetamine-induced neurotoxicity through DDAH/ADMA/NOS pathway. Neurochem Int. 2013 Jun;62(8):1055-64. (IF:2.659)
Weixia Weng，Hong Liu，Shuanglin Li，Jianye Ge，Huijun Wang*,Chao Liu. Mutation rates at 16 Y-chromosome STRs in the South China Han population. Int J Legal Med.2012 Oct 23. (IF:2.686)
Dong-Ri Li，Fu Zhang , Yao Wang , Huijun Wang*, Quantitative analysis of GFAP- and S100 protein-immunopositive astrocytes to investigate the severity of traumatic brain injury. Legal Medicine 14 (201203) 84–92 (IF:1.238)
Xia YUE, Dongfang QIAO, Aifeng WANG, Xiaohui TAN, Yanhong LI, Chao LIU，Huijun Wang*.CD200 Attenuates Methamphetamine-induced Microglial Activation and Dopamine Depletion*.J Huazhong Univ Sci Technol32(3):415-421,201206 (IF: 0.385)
Xuefeng Li, Huijun Wang*, Pingming Qiu, Hong Luo. Proteomic profiling of proteins associated with methamphetamine-induced neurotoxicity in different regions of rat brain. Neurochemistry International 52 (2008) 256–264 (IF:3.228)
Chao liu,Changhui Liu, Huijun Wang*. Genetic diversity at 15 STR Loci in two tribal populations in Southern China.Forensic Science International.2006 (IF:2.307)
Chao liu,Changhui Liu,Huijun Wang*. STR data for the 15 Loci from three minority populations in Guabgxi municipality in South China .Forensic Science International.2006 (IF:2.307)
Wang Huijun ,Ding Yanqing, Xujun etal. Death of a SARS case from secondary aspergilus Infection. Chinese Medical Journal 2004;117(8):1278-1280 (SCI收录)
Wang.Huijun, Ding, Yanqing, Pei Guoxian, et al . A preliminary pathological study on human allotransplantation. Chinese Journal of Traumatology (English Edition) 2003; 6(5):284-287 (SCI收录)
Wang.Huijun, Ding, Yanqing, Li Xin, Yang lei, Zhang wenli, Kang Wei. Fatal Aspergillosis in a Patient with SARS Who Was Treated with Corticosteroids. New England Journal of Medicine, 2003; 349（5）:507-508 (IF=34.833)
Ding Yanqing,Wang Huijun，Shen Hong et al.Clinical pathology of severe acute respiratory syndrome, a report from China.J. of Pathology,2003;200（3）：282 (IF=5.6)
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