Karakesisoglou, Akis (Iakowos) - Durham University - School of Biological and Biomedical Science

个人简介

BSc: 1993 University of Athens, Greece PhD: 1996 Ludwig-Maximilians University Munich, Germany Postdoctoral fellow: 1997-2002 University of Chicago, USA Group leader: 2002-2007 University of Cologne, Germany Senior Lecturer: 2007-present University of Durham, UK

研究领域

Structure and Function of the Nuclear Envelope The Role of the Cytoskeleton in Cell Architecture The Role of LINC Complex Proteins in Breast Cancer Metastasis The Role of LINC Complex Proteins in Motor Neuron Degeneration Premature and Physiological Human Ageing Skin Biology and Ageing Tissue and Animal Morphogenesis Stem Cell Biology and Tissue Engineering

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Cartwright, S. & Karakesisoglou, I. (2014). Nesprins in health and disease. Seminars in Cell and Developmental Biology 29: 169-179. Taranum, S., Sur, I., Muller, R., Lu, W. Rashmi, R.N. Munch, M., Neumann, S., Karakesisoglou, I. & Noegel, A.A. (2012). Cytoskeletal interactions at the nuclear envelope mediated by Nesprins. International Journal of Cell Biology 2012: 736524. Lui-Roberts, W., Stinchcombe, J.C., Ritter, A.T., Akhmanova, A., Karakesisoglou, I. & Griffiths, G.M. (2012). Cytotoxic T lymphocyte effector function is independent of nucleus–centrosome dissociation. European Journal of Immunology 42(8): 2132-2141. Taranum, S., Vaylann, E., Meinke, P., Abraham, S., Yang, L., Neumann, S., Karakesisoglou, I., Wehnert, M. & Noegel, A.A. (2012). LINC complex alterations in DMD and EDMD/CMT fibroblasts. European Journal of Cell Biology 91(8): 614-628. Lu, W., Schneider, M., Neumann, S., Jaeger, V-M., Taranum, S., Munck, M., Cartwright, S., Richardson, C., Carthew, J., Noh, K., Goldberg, M., Noegel, A. & Karakesisoglou, I. (2012). Nesprin interchain associations control nuclear size. Cellular and Molecular Life Sciences 69(20): 3493-3509. Rashmi R.N., Eckes B., Gl?ckner G., Groth M., Muller R., Munck M., Neumann S., Gloy J., Sellin L., Walz G., Schneider M., Karakesisoglou I., Eichinger L. & Noegel A.A. (2012). Roles for nuclear envelope associated Nesprin-2 Giant in cell differentiation, proliferation and chromatin association in a mouse model. Nucleus 3(2): 172-186. Schneider, M., Lu, W., Neumann, S., Brachner, A., Gotzmann, J., Noegel, A.A. & Karakesisoglou, I. (2011). Molecular mechanisms of centrosome and cytoskeleton anchorage at the nuclear envelope. Cellular and Molecular Life Sciences 68(9): 1593-1610. Zwerger, M., Kolb, T., Richter, K., Karakesisoglou, I. & Herrmann, H. (2010). Induction of a massive endoplasmic reticulum and perinuclear space expansion by expression of lamin B receptor mutants and the related sterol reductases TM7SF2 and DHCR7. Molecular Biology of the Cell 21(2): 354-368. Neumann, S., Schneider, M., Daugherty, R.L., Gottardi, C.J., Eming, S., Beijer, A., Noegel, A.A. & Karakesisoglou, I. (2010). Nesprin-2 interacts with α-Catenin and regulates Wnt signaling at the nuclear envelope. Journal of Biological Chemistry 285(45): 34932-34938. A.L. Olins, T.V. Hoang, M. Zwerger, H. Herrmann, H. Zentgraf, A.A. Noegel, I. Karakesisoglou, D. Hodzic & D.E. Olins (2009). The LINC-less granulocyte nucleus. European Journal of Cell Biology 88(4): 203-14. W. Stoffel, B. Holz, B. Jenke, E. Binczek, R.H. Gunter, C. Kiss, I. Karakesisoglou, M. Thevis, A.A. Weber, S. Arnhold & K. Addicks (2008). Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids. EMBO Journal 27(17): 2281-2292. M. Schneider, A.A. Noegel & I. Karakesisoglou (2008). KASH-domain proteins and the cytoskeletal landscapes of the nuclear envelope. Biochem Soc Trans 36(Pt 6): 1368-72. Y. Luke, H. Zaim, I. Karakesisoglou, V.M. Jaeger, L. Sellin, W. Lu, M. Schneider, S. Neumann, A. Beijer, M. Munck, V.C. Padmakumar, J. Gloy, G. Walz & A.A. Noegel (2008). Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin. Journal of Cell Science 121(11): 1887-1898. W. Lu, J. Gotzmann, L. Sironi, V.M. Jaeger, M. Schneider, Y. Luke, M. Uhlen, C.A. Szigyarto, A. Brachner, J. Ellenberg, R. Foisner, A.A. Noegel & I. Karakesisoglou (2008). Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta 1783(12): 2415-26. V. Peche, S. Shekar, M. Leichter, H. Korte, R. Schroder, M. Schleicher, T.A. Holak, C.S. Clemen, Y.B. Ramanath, G. Pfitzer, I. Karakesisoglou & A.A. Noegel (2007). CAP2, cyclase-associated protein 2, is a dual compartment protein. Cell Mol Life Sci 64(19-20): 2702-15. S. Kandert, Y. Luke, T. Kleinhenz, S. Neumann, W. Lu, V.M. Jaeger, M. Munck, M. Wehnert, C.R. Muller, Z. Zhou, A.A. Noegel, M.C. Dabauvalle & I. Karakesisoglou (2007). Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells. Human Molecular Genetics 16(23): 2944-2959. Libotte, T., Zaim, H., Abraham, S., Padmakumar, V. C., Schneider, M., Lu, W. S., Munck, M., Hutchison, C., Wehnert, M., Fahrenkrog, B., Sauder, U., Aebi, U., Noegel, A. A. & Karakesisoglou, I. (2005). Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope. Molecular Biology of the Cell 16(7): 3411-3424. Padmakumar, V. C., Libotte, T., Lu, W. S., Zaim, H., Abraham, S., Noegel, A. A., Gotzmann, J., Foisner, R. & Karakesisoglou, I. (2005). The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. Journal of Cell Science 118(15): 3419-3430. V.C. Padmakumar, S. Abraham, S. Braune, A.A. Noegel, B. Tunggal, I. Karakesisoglou & E. Korenbaum (2004). Enaptin, a giant actin-binding protein, is an element of the nuclear membrane and the actin cytoskeleton. Exp Cell Res 295(2): 330-9. Kodama, A., Karakesisoglou, I., Wong, E., Vaezi, A. & Fuchs, E. (2003). ACF7: An essential integrator of microtubule dynamics. Cell 115(3): 343-354.