Gatehouse, John A. - Durham University - School of Biological and Biomedical Science

个人简介

Postdoctoral Research Assistant 1976-1979; Addison Wheeler Research Fellow 1979-1984; Lecturer 1984-1997; Reader 1997-2011; Professor 2011-present. Currently Deputy Head of School and Director of Undergraduate Teaching

研究领域

Biochemistry and molecular biology of plant-insect interactions Expression of recombinant plant and insect proteins in microorganisms Genetic engineering of plants for insect resistance Insect biochemistry and molecular biology Plant biochemistry and molecular biology Protein engineering

近期论文

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Yang, S., Fitches, E., Pyati, P. & Gatehouse, J.A. (2015). Effect of insecticidal fusion proteins containing spider toxins targeting sodium and calcium ion channels on pyrethroid-resistant strains of peach-potato aphid (Myzus persicae). Pest Management Science 71(7): 951-956. Yang, S., Pyati, P., Fitches, E. & Gatehouse, J.A. (2014). A recombinant fusion protein containing a spider toxin specific for the insect voltage-gated sodium ion channel shows oral toxicity towards insects of different orders. Insect Biochemistry and Molecular Biology 47: 1-11. Price, D.R.G. & Gatehouse, J.A. (2014). Genome-wide annotation and functional identification of aphid GLUT-like sugar transporters. BMC Genomics 15: 647. Nakasu, Y.E.T., Williamson, S.M., Edwards, M.G., Fitches, E.C., Gatehouse, J.A., Wright, G. & Gatehouse, A.M.R. (2014). Novel biopesticide based on a spider venom peptide shows no adverse effects on honeybees. Proceedings of the Royal Society B: Biological Sciences 281(1787): 20140619. Nakasu, Erich Y.T., Edwards, Martin G., Fitches, Elaine C., Gatehouse, John A. & Gatehouse, Angharad M.R. (2014). Transgenic plants expressing -ACTX-Hv1a and snowdrop lectin (GNA) fusion protein show enhanced resistance to aphids. Frontiers in Plant Science 5: 673. Fitches, E.C., Pyati, P., King, G.F. & Gatehouse, J.A. (2012). Fusion to snowdrop lectin magnifies the oral activity of insecticidal omega-Hexatoxin-Hv1a peptide by enabling its delivery to the central nervous system. PLoS ONE 7(6): e39389. Pyati, Prashant, Chellamuthu, Anitha, Gatehouse, Angharad M. R., Fitches, Elaine & Gatehouse, John A. (2012). Insecticidal activity of wheat Hessian fly responsive proteins HFR-1 and HFR-3 towards a non-target wheat pest, cereal aphid (Sitobion avenae F.). Journal of Insect Physiology 58(7): 991-999. Ferry, N., Stavroulakis, S., Guan, W., Davison, G.M., Bell, H.A., Weaver, R.J., Down, R.E., Gatehouse, J.A. & Gatehouse, A.M.R. (2011). Molecular interactions between wheat and cereal aphid (Sitobion avenae): Analysis of changes to the wheat proteome. PROTEOMICS 11(10): 1985-2002. Pyati, P., Bandani, A.R., Fitches, E. & Gatehouse, J.A. (2011). Protein digestion in cereal aphids (Sitobion avenae) as a target for plant defence by endogenous proteinase inhibitors. Journal of Insect Physiology 57(7): 881-891. Fang, Q, Wang, F, Gatehouse, J.A., Gatehouse, A.M.R., Chen, X-X, Hu, C & Ye, G-Y (2011). Venom of Parasitoid, Pteromalus puparum, Suppresses Host, Pieris rapae, Immune Promotion by Decreasing Host C-Type Lectin Gene Expression. PLoS ONE 6(10): e26888. Hinchliffe, G, Bown, DP, Gatehouse, JA & Fitches, E (2010). Insecticidal activity of recombinant avidin produced in yeast. Journal of Insect Physiology 56(6): 629-639. Price, DRG, Tibbles, K, Shigenobu, S, Smertenko, A, Russell, CW, Douglas, AE, Fitches, E, Gatehouse, AMR & Gatehouse, JA (2010). Sugar transporters of the major facilitator superfamily in aphids; from gene prediction to functional characterization. Insect Molecular Biology 19(S2): 97-112. Pyati, PS, Bell, HA, Fitches, E, Price, DRG, Gatehouse, AMR & Gatehouse, JA (2009). Cathepsin L-like cysteine proteinase (DcCathL) from Delia coarctata (wheat bulb fly): Basis of insecticidal activity. Insect Biochemistry and Molecular Biology 39(8): 535-546. Gatehouse, JA (2008). Biotechnological prospects for engineering insect-resistant plants. Plant Physiology 146(3): 881-887. Price, DRG & Gatehouse, JA (2008). RNAi-mediated crop protection against insects. Trends in Biotechnology 26(7): 393-400. Trung, NP, Fitches, E & Gatehouse, JA (2006). A fusion protein containing a lepidopteran-specific toxin from the South Indian red scorpion (Mesobuthus tamulus) and snowdrop lectin shows oral toxicity to target insects. BMC Biotechnology 6: 18. Mehlo, L, Gahakwa, D, Nghia, PT, Loc, NT, Capell, T, Gatehouse, JA, Gatehouse, AMR & Christou, P (2005). An alternative strategy for sustainable pest resistance in genetically enhanced crops. Proceedings Of The National Academy Of Sciences Of The United States Of America 102(22): 7812-7816. Fitches, E, Edwards, MG, Mee, C, Grishin, E, Gatehouse, AMR, Edwards, JP & Gatehouse, JA (2004). Fusion proteins containing insect-specific toxins as pest control agents: snowdrop lectin delivers fused insecticidal spider venom toxinto insect haemolymph following oral ingestion. Journal Of Insect Physiology 50(1): 61-71. Fitches, E, Audsley, N, Gatehouse, JA & Edwards, JP (2002). Fusion proteins containing neuropeptides as novel insect control agents: snowdrop lectin delivers fused allatostatin to insect haemolymph following oral ingestion. Insect Biochemistry And Molecular Biology 32(12): 1653-1661. Gatehouse, JA (2002). Plant resistance towards insect herbivores: a dynamic interaction. New Phytologist 156(2): 145-169.