Denny, Paul - Durham University - School of Biological and Biomedical Science

研究领域

Cell Biology Lipid Biochemistry Molecular Biology Parasitology

近期论文

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Bolt, H.L., Eggimann, G.A., Denny, P.W. & Cobb, S.L. (2016). Enlarging the chemical space of anti-leishmanials: a structure-activity relationship study of peptoids against Leishmania mexicana, a causative agent of cutaneous leishmaniasis. Medicinal Chemistry Communications 7(5): 799-805. Gr?ftehauge, M.K., Truan, D., Vasil, A., Denny, P.W., Vasil, M.L. & Pohl, E. (2015). Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide Adduct. International Journal of Molecular Sciences 16(7): 15971-15984. Eggimann, G.A., Bolt, H.L., Denny, P.W. & Cobb, S.L. (2015). Investigating the Anti-leishmanial Effects of Linear Peptoids. ChemMedChem 10(3): 233-237. Eggimann, G.A., Sweeney, K., Bolt, H.L., Rozatian, N., Cobb, S.L. & Denny, P.W. (2015). The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides. Molecules 20(2): 2775-2785. Denny, P.W. & Steel, P.G. (2015). Yeast as a Potential Vehicle for Neglected Tropical Disease Drug Discovery. Journal of Biomolecular Screening 20(1): 56-63. Norcliffe, J.L., Alvarez-Ruiz, E., Martin-Plaza, J.J., Steel, P.G. & Denny, P.W. (2014). The utility of yeast as a tool for cell-based, target-directed high-throughput screening. Parasitology 141(1): 8-16. Trm?i?, M., Chadbourne, F.L., Brear, P.M., Denny, P.W., Cobb, S.L. & Hodgson, D.R.W. (2013). Aqueous synthesis of N,S,-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing. Organic and Biomolecular Chemistry 11(16): 2660-2675. Pratt, S., Wansadhipathi-Kannangara, N.K., Bruce, C.R., Mina, J.G., Shams-Eldin, H., Casas, J., Hanada, K., Schwarz, R.T., Sonda, S. & Denny, P.W. (2013). Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondii. Molecular and Biochemical Parasitology 187(1): 43-51. Ali, H.Z., Harding, C.R. & Denny, P.W. (2012). Endocytosis and sphingolipid scavenging in Leishmania mexicana amastigotes. Biochemistry Research International 2012: 691363. Smith, TK, Reynolds, TB & Denny, PW (2012). Lipid Metabolism as a Therapeutic Target (Editorial). Biochemistry Research International 2012: 158139 Young, S.A., Mina, J.G., Denny, P.W. & Smith, T.K. (2012). Sphingolipid and ceramide homeostasis, potential therapeutic targets. Biochemistry Research International 2012: 248135. Mina, J.G., Mosely, J.A., Ali, H.Z., Denny P.W. & Steel, P.G. (2011). Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain. Organic and Biomolecular Chemistry 9(6): 1823-1830. Featured in: Sheridan, C. (2011). Industry continues dabbling with open innovation models. Nature Biotechnology 29(12): 1063-1065. Chadbourne, F.L., Raleigh, C., Ali, H.Z., Denny, P.W. & Cobb, S.L. (2011). Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa. Journal of Peptide Science 17(11): 751-755. Mina, J.G., Mosely, J.A., Ali, H.Z., Shams-Eldin, H., Schwarz, R.T., Steel, P.G. & Denny, P.W. (2010). A plate-based assay system for analyses and screening of the Leishmania major inositol phosphorylceramide synthase. International Journal of Biochemistry and Cell Biology 42(9): 1553-1561. Cobb, S.L. & Denny, P.W. (2010). Antimicrobial peptides for leishmaniasis. Current Opinion in Investigational Drugs 11(8): 868-875. Mina, J.G., Okada, Y. , Wansadhipathi-Kannangara, N.K., Pratt, S., Shams-Eldin, H., Schwarz, R.T., Steel, P.G., Fawcett, T. & Denny, P.W. (2010). Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase. Plant Molecular Biology 73(4-5): 399-407. Mina, J.G., Pan, S.Y., Wansadhipathi, N.K., Bruce, C., Shams-Eldin, H., Schwarz, R.T., Steel, P.G. & Denny, P.W. (2009). The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target. Molecular And Biochemical Parasitology 168(1): 16-23. Featured in: In Brief (2006). Research Highlights. Nature Reviews Drug Discovery 5(9): 722. Denny, P. W., Shams-Eldin, H., Price, H. P., Smith, D. F. & Schwarz, R. T. (2006). The protozoan inositol phosphorylceramide synthase: A novel drug target that defines a new class of sphingolipid synthase. Journal Of Biological Chemistry 281(38): 28200-28209.