Chazot, P - Durham University - School of Biological and Biomedical Science

个人简介

PRESIDENT, European Histamine Research Society (EHRS) (2012-2018) FELLOW and AMBASSADOR, British Pharmacological Society (2012-present day) VICE CHAIR and CO-APPLICANT, EU COST ACTION BM0806 (2009-2013) CHAIR, International Union of Pharmacological Societies Subcommittee (2011-present day) DURHAM LGR/COMMITTEE OFFICER (2008- ) British Neuroscience Association PRESIDENT, Parkinson’s UK North Durham Branch (2010 – present day) SCIENCE EDITOR & CO-FOUNDER, Trends in Anaesthesia and Critical Care (TACC) (2010-) THEME EDITOR, Histamine Pharmacology 2009 and 2013 British Journal of Pharmacology ASSISTANT EDITOR Inflammation Research (2004-present day) EDITOR: European Journal of Medicinal Plants (2011- ) FOUNDER and DIRECTOR, WOLFSON RESEARCH INSTITUTE SPECIAL INTEREST GROUP – PAIN (2012-present day)

研究领域

Dr Chazot’s group is interested in identifying, studying and validating novel drug targets for treating acute brain damage and a range of common chronic neuro- and immuno-pathologies. His favourite molecules to study are histamine (http://www.ehrs.org.uk/ and http://www.histamineresearch.com) and glutamate. Technologies employed include immunobiochemistry, molecular biology, ligand autoradiography, radioligand binding, heterologous expression, primary neuronal cultures, adenoviral transfection, in vitro electrophysiology, in vivo behavioural testing

近期论文

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Ennaceur, A., Hussain, M.D., Abuhamdah, R.M., Mostafa, R.M. & Chazot, P.L. (2017). Slope climbing challenges, fear of heights, anxiety and time of the day. Behavioural Brain Research 316: 169-182. Wang, J.G., Wang, Y.L., Xu, F., Zhao, J.X., Zhou, S.Y., Yu, Y., Chazot, P.L., Wang, X.F. & Lu, C.B. (2016). Activity- and development-dependent down-regulation of TARPγ8 and GluA1 in cultured rat hippocampal neurons. Acta Pharmacologica Sinica 37(3): 303-311. Lethbridge, N.L. & Chazot, P.L. (2016). Ligand autoradiographical quantification of histamine H3 receptor in human dementia with Lewy bodies. Pharmacological Research 113(Part A): 245-256. Abuhamdah, R.M., Hussain, M.D., Chazot, P.L. & Ennaceur, A. (2016). Pre-training in a radial arm maze abolished anxiety and impaired habituation in C57BL6/J mice treated with dizocilpine. Physiology & Behavior 164(Part A): 353-360. Ennaceur, A. & Chazot, P.L. (2016). Preclinical animal anxiety research - flaws and prejudices. Pharmacology Research & Perspectives 4(2): n/a. Lucarini, L., Pini, A., Rosa, A.C., Lanzi, C., Durante, M., Chazot, P.L., Krief, S., Schreeb, A., Stark, H. & Masini, E. (2016). Role of Histamine H4 Receptor ligands in Bleomycin-induced pulmonary fibrosis. Pharmacological Research 111: 740-748. Chen, Y., Paavola, J., Stegajev, V., Stark, H., Chazot, P.L., Wen, J.G. & Konttinen, Y.T. (2015). Activation of histamine H3 receptor decreased cytoplasmic Ca(2+) imaging during electrical stimulation in the skeletal myotubes. European Journal of Pharmacology 754: 173-178. Abuhamdah, R.M., Hussain, M.D., Chazot, P.L. & Ennaceur, A. (2015). Effects of chronic fluoxetine treatment on anxious behaviour of BALB/c mice in a 3-dimensional maze. Stress 18(6): 677-685. Pini, A., Chazot, P.L. (joint 1st author), Veglia, E., Moggio, A. & Rosa, A.C. (2015). H3 receptor renal expression in normal and diabetic rats. Inflammation Research 64(5): 271-273. Veglia, E., Grange, C., Pini, A, Moggio, A., Lanzi, C., Camussi, G., Chazot, P.L. & Rosa, A.C. (2015). Histamine receptor expression in human renal tubules: a comparative pharmacological evaluation. Inflammation Research 64(3-4): 261-270. Chen, Y., Stegaev, V., Kouri, V.P., Sillat, T., Chazot, P.L., Stark, H., Wen, J.G. & Konttinen, Y.T. (2015). Identification of histamine receptor subtypes in skeletal myogenesis. Molecular Medicine Reports 11(4): 2624-2630. Abuhamdah, S., Abuhamdah, R., Howes, M.J., Al-Olimat, S., Ennaceur, A. & Chazot, P.L. (2015). Pharmacological and neuroprotective profile of an essential oil derived from leaves of Aloysia citrodora?Palau. Journal of Pharmacy and Pharmacology 67(9): 1306-1315. Dib, K., Perecko, T., Jenei, V., McFarlane, C., Comer, C., Brown, V., Katebe, M., Scheithauer, T., Thurmond, R.L., Chazot, P.L. & Ennis, M. (2014). The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils. Journal of Leukocyte Biology 96(3): 411-419. Wang, M., Chazot, P.L., Ali, S., Duckett, S.F. & Obrenovitch, T.P. (2012). Effects of NMDA receptor antagonists with different subtype selectivities on retinal spreading depression. British Journal of Pharmacology 165(1): 235-244. Ennaceur A, Michalikova S, van Rensburg R & Chazot PL (2011). MK-801 increases baseline level of anxiety in mice introduced to a spatial memory task without prior habituation. Neuropharmacology 61(5-6): 981-991. van Rensburg, R, Errington, DR, Ennaceur, A, Lees, G, Obrenovitch, TP & Chazot, PL (2009). A new model for the study of high-K(+)-induced preconditioning in cultured neurones: role of N-methyl-d-aspartate and alpha7-nicotinic acetylcholine receptors. Journal of Neuroscience Methods 177(2): 311-316. Ennaceur, A. Michalikova, S. & Chazot, P.L. (2009). Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space. Behavioural Brain Research 197(2): 417-434. Connolly, W, Shenton, FC, Lethbridge N, Leurs R, Waldvogel HJ, Faull RLM, Lees G & Chazot PL (2009). The histamine H4 receptor is functionally expressed on neurons in the mammalian CNS. British Journal of Pharmacology 157(1): 55-63. Dijkstra, D., Stark, H., Chazot, P.L., Shenton, F.C., Leurs, R., Werfel, T. & Gutzmer, R. (2008). Human Inflammatory Dendritic Epidermal Cells Express a Functional Histamine H4 Receptor. Journal of Clinical and Investigative Dermatology 128(7): 1696-1703. Van Rijn, RM., Chazot, PL., Shenton, FC., Sansuk, K., Bakker, RA. & Leurs, R. (2006). Oligomerization of recombinant and endogenously expressed human histamine H4 receptors. Molecular Pharmacology 70(2): 604-615. Abuhamdah, S., Fuerstner, A., Lees, G. & Chazot, PL. (2005). Radioligand binding studies of caloporoside and novel congeners with contrasting effects upon [35S] TBPS binding to the mammalian GABAA receptor. Biochemical Pharmacology 70(9): 1382-1388. Chazot, PL., Godukhin, OV., McDonald A. & Obrenovitch, TP. (2002). Spreading Depression-induced preconditioning in the mouse cortex: Differential changes in the protein expression of ionotropic nicotinic acetylcholine and glutamate receptors. Journal of Neurochemistry 83(5): 1235-1238. Chazot, PL., Lawrence, S. & Thompson, CL. (2002). Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2B-selective NMDA receptor antagonists. Neuropharmacology 42(3): 319-324.