Cann, Martin - Durham University - School of Biological and Biomedical Science

研究领域

Cell biology of bicarbonate and carbon dioxide Cyclic nucleotide signaling Signal transduction

近期论文

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Turner, M.J., Saint-Crib, V., Patel, W., Ibrahim, S.H., Verdon, B., Ward, C., Garnett, J.P., Tarran, R., Cann, M.J. & Gray, M.A. (2016). Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator-dependent anion and fluid secretion in airway epithelia. The Journal of Physiology 594(6): 1643-1661. Fenyk, S., Dixon, C.H., Kittens, W.H., Townsend, P.D., Sharpies, G.J., P?lsson, L.-O., Takken, F.L.W. & Cann, M.J. (2016). The tomato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor I-2 couples DNA-Binding to Nucleotide-Binding Domain Nucleotide Exchange. Journal of Biological Chemistry 291(3): 1137-1147. McLeish, T.C.B., Cann, M.J. & Rodgers, T.L. (2015). Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?. Biophysical Journal 109(6): 1240-1250. Townsend, P.D., Rogers, T.L., Pohl, E., Wilson, M.R., McLeish, T.C.B. & Cann, M.J. (2015). Global low-frequency motions in protein allostery: CAP as a model system. Biophysical Reviews 7(2): 175-182. Fenyk, Stepan, Townsend, Philip D., Dixon, Christopher H., Spies, Gerhard B., de San Eustaquio Campillo, Alba, Slootweg, Erik J., Westerhof, Lotte B., Gawehns, Fleur K.K., Knight, Marc R., Sharples, Gary J., Goverse, Aska, P?lsson, Lars-Olof, Takken, Frank L.W. & Cann, Martin J. (2015). The Potato Nucleotide-Binding Leucine-Rich Repeat (NLR) Immune Receptor Rx1 is a Pathogen Dependent DNA-Deforming Protein. Journal of Biological Chemistry 290(41): 24945-24960. Townsend, P.D., Rodgers, T.L., Glover, L.C., Korhonen, H.J., Richards, S.A., Colwell, L.J., Pohl, E., Wilson, M.R., Hodgson, D.R.W., McLeish, T.C.B. & Cann, M.J. (2015). The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein. Journal of Biological Chemistry 290(36): 22225-22235. Townsend, P., Jungwirth, B., Pojer, P., Bu?mann, M., Money, V.A., Cole, S.T., Pühler, A., Tauch, A., Bott, M., Cann, M.J. & Pohl, E. (2014). The crystal structures of apo and cAMP-bound GlxR from Corynebacterium glutamicum reveal structural and dynamic changes upon cAMP binding in CRP/FNR family transcription factors. PlosONE 9(12): e113265. Meigh, L., Greenhalgh, S.A., Rodgers, T.L., Cann, M.J., Roper, D.I. & Dale, N. (2013). CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits. eLife 2: e01213. Rodgers, TL, Townsend, PD, Burnell, D, Jones, ML, Richards, SA, McLeish, TCB, Pohl, E, Wilson, MR & Cann, MJ (2013). Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors. PLoS Biology 11(9): e1001651. Fenyk, S, de San Eustaquio Campillo, A, Pohl, E, Hussey, PJ & Cann, MJ (2012). A Nucleotide Phosphatase Activity in the Nucleotide Binding Domain of an Orphan Resistance Protein from Rice. The Journal of Biological Chemistry 287(6): 4023-4032. Topal, H, Fulcher, NB, Bitterman, J, Salazar, E, Buck, J, Levin, LR, Cann, MJ, Wolfgang, MC & Steegborn, C (2012). Crystal Structure and Regulation Mechanisms of the CyaB Adenylyl Cyclase from the Human Pathogen Pseudomonas aeruginosa. Journal of Molecular Biology 416(2): 271-286. Cook, Z.C., Gray, M.A. & Cann, M.J. (2012). Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca2+ Release. Journal of Biological Chemistry 287(31): 26291-26301. Fulcher, NB, Holliday, PM, Klem, E, Cann, MJ & Wolfgang, MC (2010). The Pseudomonas aeruginosa Chp chemosensory system regulates intracellular cAMP levels by modulating adenylate cyclase activity. Molecular Microbiology 76(4): 889-904. Townsend, PD, Holliday, PM, Fenyk, S, Hess, KC, Gray, MA, Hodgson, DRW & Cann, MJ (2009). Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide. Journal Of Biological Chemistry 284(2): 784-791. Cann, M (2007). A subset of GAF domains are evolutionarily conserved sodium sensors. Molecular Microbiology 64(2): 461-472. Cann, M.J. (2007). Sodium regulation of GAF domain function. Biochemical Society Transactions 35(5): 1032-1034. Williamson, D., Cann, M.J. & Hodgson, D.R.W. (2007). Synthesis of 5'-Amino-5'-deoxyguanosine-5'-N-phosphoramidate and its Enzymatic Incorporation at the 5'-Termini of RNA Molecules. Chemical Communications 2007(47): 5096-5098. J.H. Yu, D. Parker, R. Pal, R.A. Poole & M.J. Cann (2006). A europium complex that selectively stains nucleoli of cells. Journal of the American Chemical Society 128(7): 2294-2299. Hammer, A., Hodgson, D.R.W. & Cann, M.J. (2006). Regulation of prokaryotic adenylyl cyclases by CO?. Biochemical Journal 396(2): 215-218. R. A. Poole, G. Bobba, M. J. Cann, J. C. Frias, D. Parker & R. D. Peacock (2005). Synthesis and characterisation of highly emissive and kinetically stable lanthanide complexes suitable for usage 'in cellulo'. Organic & Biomolecular Chemistry 3(6): 1013-1024.