Benham, Adam - Durham University - School of Biological and Biomedical Science

研究领域

Antigen processing and presentation Oxidative folding of proteins in the Endoplasmic Reticulum

近期论文

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Tokuhiro, K., Satouh, Y., Nozawa, K., Isotani, A., Fujihara, Y., Hirashima, Y., Matsumura, H., Takumi, K., Miyano, T., Okabe, M., Benham, A.M. & Ikawa, M. (2015). Calreticulin is required for development of the cumulus oocyte complex and female fertility. Scientific Reports 5: 14254. Tarran, W. A., Freeman, G. R., Murphy, L., Benham, A. M., Kataky, R. & Williams, J. A. G. (2014). Platinum(II) Complexes of N^C^N?Coordinating 1,3-Bis(2-pyridyl)benzene Ligands: Thiolate Coligands Lead to Strong Red Luminescence from Charge-Transfer States. Inorganic Chemistry 53(11): 5738–5749. Battle, D.M., Dias-Gunasekara, S., Watson, G.R. , Mohamed Ahmed, E., Saysell, C.G., Altaf, N., Sanusi, A.L., Munipalle, P., Scoones, D., Walker, J., Viswanath, Y. & Benham, A.M. (2013). Expression of the Endoplasmic Reticulum Oxidoreductase Ero1α in gastro-intestinal cancer reveals a link between homocysteine and oxidative protein folding. Antioxidants and Redox Signaling 19(1): 24-45. Benham, A.M., van Lith, M., Sitia, R. & Braakman, I. (2013). Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philosophical Transactions of the Royal Society B: Biological Sciences 368(1617): 20110403. Tokuhiro, K., Ikawa, M., Benham, AM. & Okabe, M. (2012). Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proceedings of the National Academy of Sciences of the United States of America 109(10): 3850-3855. Benham, A.M (2012). Protein secretion and the endoplasmic reticulum. In Protein Synthesis and Translational Control. Hershey, JWB, Sonenberg, N & Mathews, MB Cold Spring Harbor Press. 4: 147-162. Benham, A.M. (2012). The protein disulfide isomerase family: key players in health and disease. Antioxidants & Redox Signaling 16(8): 781-789. Ikawa, M., Tokuhiro, K., Yamaguchi, R., Benham, AM., Tamura, T., Wada, I., Satouh, Y., Inoue, N. & Okabe, M. (2011). Calsperin is a testis-specific chaperone required for sperm fertility. Journal of Biological Chemistry 286(7): 5639-5646. van Lith, M., McEwen-Smith, RM. & Benham, AM. (2010). HLA-DP, HLA-DQ and HLA-DR have different requirements for invariant chain and HLA-DM. Journal of Biological Chemistry 285(52): 40800-40808. Ikawa, M., Inoue, N., Benham, A.M. & Okabe, M. (2010). Fertilization: a sperm's journey to and interaction with the oocyte. Journal Clinical Investigation 120(4): 984-994. Benham, A.M. (2009). Protein folding and disulfide bond formation in the eukaryotic cell. FEBS Journal 276(23): 6905-11. van Lith, M., Karala, A., Bown, D., Gatehouse, J., Ruddock, L., Saunders, P & Benham, AM. (2007). A developmentally regulated chaperone complex for the endoplasmic reticulum of male haploid germ cells. Molecular Biology of the Cell 18(8): 2795-2804. Lemin, A., Saleki, K., van Lith, M. & Benham, AM. (2007). Activation of the unfolded protein response and alternative splicing of ATF6α in HLA-B27 positive lymphocytes. FEBS Letters 581: 1819-1824. van Lith, M. & Benham, AM. (2006). The DMalpha and DMbeta chain co-operate in the oxidation and folding of HLA-DM. Journal of Immunology 177(8): 5430-5439. Dias-Gunasekara, S., van Lith, M., Williams, JAG., Kataky, R. & Benham, AM. (2006). Mutations in the FAD binding domain cause stress-induced misoxidation of the endoplasmic reticulum oxidoreductase Ero1b. Journal of Biological Chemistry 281(35): 25018-25025. Saleki, K, Hartigan, N, van Lith, M, Bulleid, N & Benham, AM (2006). Differential oxidation of HLA-B2704 and HLA-B2705 in lymphoblastoid and transfected adherent cell lines. Antioxidants and Redox Signaling 8: 292-299. van Lith M, Hartigan N, Hatch J & Benham AM (2005). PDILT, a divergent testis-specific protein disulfide isomerase with a non-classical SXXC motif that engages in disulfide-dependent interactions in the endoplasmic reticulum. Journal of Biological Chemistry 280(2): 1376-1383. Dias-Gunasekara S, Gubbens J, van Lith M, Dunne C, Williams JA, Kataky R, Scoones D, Lapthorn A, Bulleid NJ & Benham AM (2005). Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Erolb. Journal of Biological Chemistry 280(38): 33066-33075. Dixon DP, van Lith M, Edwards R & Benham AM (2003). Cloning and initial characterization of the Arabidopsis thaliana Endoplasmic Reticulum Oxidoreductins. Antioxidants and Redox Signaling 4: 389-396. Mezghrani A, Fassio A, Benham AM, Simmen T, Braakman I & Sitia R (2001). Manipulation of oxidative protein folding and PDI redox state in mammalian cells. EMBO Journal 20: 6288-6296. Benham AM, Cabibbo A, Fassio A, Bulleid N, Sitia R & Braakman I (2000). The CXXCXXC motif determines the folding, structure and stability of human Ero1-La. EMBO Journal 19: 4493-4502.