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个人简介

2022年 3月-现今:福州大学化学学院 教授 博士生导师 2020 年 10 月-2022年 2月:西北工业大学 教授 博士生导师/前沿交叉研究中心主任 2019年4月-2020年9月:新加坡纳米生物国家实验室课题组长/资深研究员 2014年7月-2019年3月:新加坡生物工程和纳米技术研究院课题组长/资深研究员 2006年7月-2014年6月:新加坡国立大学化学系助理教授及国立大学药物化学平台的 核心成员 2002年3月-2006年6月:美国斯克利普斯研究所博士后。师从美国科学院及医学院双 院士Peter G. Schultz教授 2002年2月:美国纽约州立大学布法罗分校理学博士学位, 师从Gong Bing教授 1996年7月:中国科学技术大学理学学士

研究领域

研究方向为生物有机功能超分子化学 (人工离子/水/DNA/质子通道)及在海水淡化,抗癌新药和第三代基因测序技术开发中的应用)。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Jie Shen, J.; Gu, Y.; Ke, L.; Zhang, Q.; Cao, Y.; Lin, Y.; Wu, Z.; Wu, C.; Mu, Y.; Wu, Y.; Ren, C. L.;* Zeng, H. Q.,* Cholesterol-Stabilized Membrane-Active Nanopores with Potent and Specific Anticancer Activities. Nat. Commun. 2022, In revision Shen, J.; Ren, C.; Zeng, H. Q.,* Membrane-Active Molecular Machines. Acc. Chem. Res. 2022, DOI: 10.1021/acs.accounts.1c00804 Shen, J.; Ye, R.; Liu, Z; Zeng, H. Q.,* Hybrid Pyridine-Pyridone Foldamer Channels as M2-Like Artificial Proton Channels. Angew. Chem. Int. Ed. 2022, 61, DOI: 10.1002/anie.202200259 Roy, A.; Shen, J.; Joshi, H.; Song, W.; Tu, Y.-M.; Chowdhury, R.; Ye, R. J.; Li, N.; Ren, C.; Kumar, M.; Aksimentiev, A.; Zeng, H. Q.,* Foldamer-Based Ultrapermeable and Highly Selective Artificial Water Channels that Exclude Protons. Nat. Nanotech. 2021, 16, 911-917 Shen, J.; Ye, R. J.; Zeng, H. Q.,* Crystal Packing-Guided Construction of Hetero-Oligomeric Peptidic Ensembles as Synthetic 3-in-1 Transporters. Angew. Chem. Int. Ed. 2021, 60, 12924-12930 (Hot paper) Zhang, H.; Ye, R. J.; Mu, Y. G.; Li, T.; Zeng, H. Q.,* Small Molecule-Based Highly Active and Selective K+ Transporters with Potent Anticancer Activities. Nano Lett. 2021, 21, 1384–1391 Shen, J.; Han, J. J. Y.; Ye, R. J.; Zeng, H. Q.,* Molecular rotors as a class of generally highly active ion transporters. Sci. China Chem. 2021, 64, 2154-2160 Li, N.; Shen, J.; Ang, G. K.; Ye, R. J.; Zeng, H. Q.,* Molecular Tetrahedrons as Selective and Efficient Ion Transporters via a Two-Station Swing-Relay Mechanism. CCS Chem. 2020, 2, 2269-2279 Li, N.; Chen, F.; Shen, J.; Zhang, H.; Wang, T.; Ye, R. J.; Li, T.; Loh, T.P.; Yang, Y.Y.; Zeng, H. Q.,* Buckyball-Based Spherical Display of Crown Ethers for De Novo Custom Design of Ion Transport Selectivity. J. Am. Chem. Soc. 2020, 142, 21082-21090 Shen, J.; Ye, R. J.; Romanies, A.; Lin, Y.; Roy, A.; Chen, F.; Ren, C. L., Liu, Z.; Zeng, H. Q.,* Aquafoldmer-Based Aquaporin-like Synthetic Water Channel. J. Am. Chem. Soc. 2020, 142, 10050-10058 Shen, J.; Fan, J.; Ye, R. J.; Li, N.; Mu, Y.; Zeng, H. Q.,* Polypyridine-Based Helical Amide Foldamer Channels: Rapid Transport of Water and Protons with High Ion Rejection. Angew. Chem. Int. Ed. 2020, 59, 13328-13334 Roy, A.; Joshi, H.; Ye, R. J.; Shen, J.; Chen, F.; Aksimentiev, A.*; Zeng, H. Q.,* Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels. Angew. Chem. Int. Ed. 2020, 59, 4806-4813 Chen, F.; Shen, J.; Li, N.; Roy, A.; Ye, R. J.; Ren, C. L.; Zeng, H. Q.,* Pyridine/Oxadiazole-Based Helical Foldamer Ion Channels with Exceptionally High K+/Na+ Selectivity. Angew. Chem. Int. Ed. 2020, 59, 1440-1444 Ye, R. J.; Ren, C. L.; Shen, J.; Li, N.; Chen, F.; Roy, A.; Zeng, H. Q.,* Molecular Ion Fishers as Highly Active and Exceptionally Selective K+ Transporters. J. Am. Chem. Soc. 2019, 141, 9788-9792 Ren, C. L.; Chen, F.; Ye, R. J.; Ong, Y. S.; Lu, H. F.; Lee, S. S.; Ying, J. Y.-R.; Zeng, H. Q.,* Molecular swings as highly active ion transporters. Angew. Chem. Int. Ed. 2019, 58, 8034-8038 (Hot Paper) Ren, C. L.; Zeng, F.; Shen, J.; Chen, F.; Roy, A.; Zhou, S.; Ren, H.; Zeng, H. Q.,* Pore-Forming Monopeptides as Exceptionally Active Anion Channels. J. Am. Chem. Soc. 2018, 140, 8817–8826 Ren, C. L.; Ding, Z.; Roy, A.; Shen, J.; Zhou, S. Y.; Chen, F.; Li, S.; Ren, H. S..; Yang, Y. Y.; Zeng, H. Q.,* A halogen bond-mediated highly selective and active artificial chloride channel with high anticancer activity. Chem. Sci. 2018, 9, 4044-4051 (Front Cover) Ren, C. L.; Shen, J.; Zeng, H. Q.,* Combinatorial evolution of fast-conducting highly selective K+-channels via modularly tunable directional assembly of crown ethers J. Am. Chem. Soc. 2017, 139, 12338–12341 Shen, J.; Ren, C. L.; Zeng, H. Q.,* Surprisingly high selectivity and high affinity in mercury recognition by H-bonded cavity-containing aromatic foldarands. J. Am. Chem. Soc. 2017, 139, 5387–5396 Ren, C. L.; Shen, J.; Chen, F.; Zeng, H. Q.,* Rapid Room-Temperature Gelation of Crude Oils by a Wetted Powder Gelator. Angew. Chem. Int. Ed. 2017, 56, 3847-3851

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