研究领域

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Anti-Cancer Research: Tumour selective drug design, multi scale synthesis for biological evaluation. PhD thesis title, ‘Synthesis of Novel CYP1-activated Anti-cancer Prodrugs’. Area of study: Design, Synthesis and Optimisation for in-vitro biological evaluation of reference and novel small-molecules for cytochrome P450 CYP1-enzyme targeted prodrug cancer chemotherapy. This includes the design and synthesis of novel prodrugs targeted towards CYP1B1, an aromatic hydroxylase specifically expressed in all tumour samples investigated to date, but not in normal somatic tissues. The development of prodrugs is based partly on the structure of natural product, Estradiol, a known substrate of CYP1B1 activation to partly toxic 4-hydroxyestradiol. Purification by flash column chromatography or recrystallisation and analytical techniques include 1H and 13C NMR, mass spectrometry and infrared spectra analysis.