个人简介
学科建设处副处长,国家自然科学基金优秀青年基金、江苏省杰出青年基金入选者
教育经历:
2001/09 – 2005/06 华南理工大学食品与生物工程学院生物工程专业,工学学士
2005/09 – 2010/06 华南理工大学生物科学与工程学院发酵工程专业,工学博士
2007/01 – 2010/06 华南理工大学、浙江大学、Ohio University,联合培养博士
2018/04 – 2019/04 香港中文大学 访问学者
工作经历:
2017/04 – 至今 南京工业大学食品与轻工学院,教授,博士生导师
2013/07 – 2017/03 南京工业大学食品与轻工学院,副教授,硕士生导师
2012/07 – 2013/06 南京工业大学食品与轻工学院,讲师
2010/07 – 2012/06 南京工业大学生物与制药工程学院,师资博士后
奖励与荣誉
1. 2019年,入选国家自然科学基金优秀青年基金项目
2. 2018年,国家技术发明奖二等奖(排名4)
3. 2018年,教育部高校科学研究优秀成果奖技术发明奖一等奖(排名4)
4. 2018年,中国轻工业联合会技术发明奖一等奖(排名5)
5. 2018年,新疆自治区科技进步奖二等奖(排名5)
6. 2018年,入选江苏省自然科学基金杰出青年基金项目
7. 2016年,江苏省“333高层次人才”第三层次培养对象
8. 2016年,南工精英九思奖
9. 2015年,江苏省“六大人才高峰”高层次人才
10. 2013年,江苏省科协首届“首席工程师”
11. 2012年,南京领军型科技创业321人才
12. 2012年,全国百篇优秀博士学位论文提名奖
主要学术成绩:
教学方面,先后主讲《食品生物化学》、《微生物学》、《生物炼制》、《生命科学与生物技术概论》等本科生课程,担任3届新生班主任,指导本科生1人参加省级“大学生挑战杯”,指导20项大学生创新创业训练计划项目(3项获国家级立项),3次参加江苏省科协青年会员创新创业大赛并获奖,优秀指导教师三等奖1次,指导研究生获江苏省优秀硕士学位论文1次,先后荣获校第十四届“师德十佳”、第二批“名师名导百人计划”、“南工集团奖教金”、“教书育人”竞赛先进个人、大学生菁英人才学校“学术创新导师”等荣誉。
科研方面,长期从事极端微生物资源及其食品酶资源的保育和开发,围绕微生物和酶的发现、改造与高效使用等三个关键科学问题,从新疆极端微生物来源的新菌种和新糖酶基因资源的挖掘与评价、生物催化体系中糖酶的理性改造、生物转化体系中微生物的定向调控等三个方面入手,设计面向食品工业环境应用的生物催化剂(微生物和酶)改造方法,通过食品科学、食品微生物学、合成生物、酶工程、发酵工程等多学科的交叉融合,在生物催化和生物转化的共性关键技术和研究方法学等方面开展基础理论研究和应用技术研究。共发表科研论文100余篇,其中以第一或通讯作者在Trends in Biotechnology、ACS Catalysis、Biotechnology Advances、Journal of Hazardous Materials、Bioresource Technology、Carbohydrate Polymers、Green Chemistry、Journal of Agricultural and Food Chemistry等期刊发表近100篇,9篇被选为封面/封底论文,并被Chem. Rev. , Chem. Soc. Rev., Nat. Pro. Rep.等国际顶级期刊引用。授权国家发明专利29项;参编英文教材4章、中文教材1本。先后主持国家食品安全专项重点研发计划课题/子课题、国家自然科学基金优秀青年/重点(联合)/面上/青年基金、国家973和863子课题等国家级课题8项,以及江苏省自然科学基金杰出青年基金等省部级和企业横向课题10余项,以及企业横向课题2项。
基金项目(在研)
1. 国家重点研发计划课题(分子机器仿生体系构建与多酶催化空间效应探究),2022.12-2024.11,主持
2. 国家自然科学基金优秀青年项目(食品酶资源利用),2020.1-2022.12,主持
3. 国家自然科学基金重点(联合)基金(海洋细菌极端酶微环境适应进化机制及定向适配性改造),2022.1-2025.12,主持
4. 江苏省自然科学基金杰出青年基金(碳水化合物的高效高值化生物催化转化的应用基础研究),2018,7-2021.6,主持
5. 国家“十三五”重点研发计划子课题(高通量自动化样品前处理、智能化现场快检设备研制及快检方法集成),2018.12-2021.12,主持
6. 国家“十三五”重点研发计划子课题(乳制品中糠醛类危害物的形成机制及其消除技术),2017.12-2021.12,主持
近期论文
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[1]. Zhengming Zhu, Liying Zhu, Ling Jiang*. Dynamic regulation of gut Clostridium-derived short-chain fatty acids. Trends in Biotechnology. 2022, 40(3): 266-270.
[2]. Yanxia Wang, Yao Chen, Ling Jiang*, Huang He*. Improvement of the enzymatic detoxification activity towards mycotoxins through structure-based engineering. Biotechnology Advances. 2022.56, 107927.
[3]. Yuxian Wang, Matthew Jay Malkmes, Cheng Jiang, Peng Wang, Liying Zhu, Hongman Zhang, Yangheng Zhang*, He Huang*, Ling Jiang*. Antibacterial mechanism and transcriptome analysis of ultra-small gold nanoclusters as an alternative of harmful antibiotics against Gram-negative bacteria. Journal of Hazardous Materials. 2021, 416, 126236.
[4]. Tingting Liu, Matthew Jay Malkmes, Liying Zhu, He Huang, Ling Jiang*. Metal-organic frameworks coupling simultaneous saccharication and fermentation for enhanced butyric acid production from rice straw under visible light by Clostridium tyrobutyricum CtΔack::cat1. Bioresource Technology. 2021, 332, 125117.
[5]. Zhidong Zhang#, Guilin Liu#, Yao Chen, Weizhen Xue, Qianyue Ji, Qiwu Xu, He Zhang, Guangyi Fan, He Huang, Ling Jiang*, Jianwei Chen*. Comparison of different sequencing strategies for assembling chromosome-level genomes of extremophiles with variable GC content. iScience. 2021, https://doi.org/10.1016/j.isci. 2021.102219. Yuxian Wang, Liying Zhu*, Hongman Zhang, He Huang, Ling Jiang*. Formulation of pH and temperature dual-responsive Pickering emulsion stabilized by chitosan-based microgel for recyclable biocatalysis. Carbohydrate Polymers. 2020. 116373.
[6]. Liying Zhu, Bowen Shen, Zhe Song, Ling Jiang*. Permeabilized TreS-Expressing Bacillus subtilis Cells Decorated with Glucose Isomerase and a Shell of ZIF-8 as a Reusable Biocatalyst for the Coproduction of trehalose and Fructose. Journal of Agricultural and Food Chemistry. 2020, 68(15):4464-4472.
[7]. Ling Jiang, Xiaogang Song, Yingfeng Li, Qing Xu, Jiahua Pu, He Huang*, Chao Zhong*. Programming integrative extracellular and intracellular biocatalysis for rapid, robust and recyclable synthesis of trehalose. ACS Catalysis. 2018, 8: 1837−1842.
[8]. Ling Jiang, Hongxin Fu, Hopen K. Yang, Wei Xu, Jufang Wang*, Shang-Tian Yang*. Butyric acid: Applications and recent advances in its bioproduction. Biotechnology Advances. 2018, 36(8): 2101−2117.
[9]. Wenxiu Zheng, Xujie Liu, Liying Zhu, He Huang, Tianfu Wang, Ling Jiang*, Pretreatment with γ-valerolactone/[Mmim] DMP and enzymatic hydrolysis on corncob and its application for immobilized butyric acid fermentation. Journal of Agricultural and Food Chemistry.2018, 66: 11709−11717.
[10]. Xincheng Yan, Liying Zhu, Yadong Yu, Qing Xu, He Huang, Ling Jiang*. In situ Biocatalytic Production of Trehalose with Auto-Induction Expression of Trehalose Synthase. Journal of Agricultural and Food Chemistry. 2018, 66: 1444−1451.
[11]. Jingjing Bao, Nian Liu, Qing Xu, Lingying Zhu, He Huang, Ling Jiang*. Programming biofilm-mediated multi-enzyme assembly cascade system for biocatalytic production of glucosamine from chitin. Journal of Agricultural and Food Chemistry. 2018, 66: 8061−8068.
[12]. Chu Shi, Qing Xu, Yue Ge, Ling Jiang*, He Huang*. A luciferase-zinc finger system for the rapid detection of pathogenic bacteria. Journal of Agricultural and Food Chemistry. 2017, 65, 6674-6681.
[13]. Qian Wu, Liying Zhu, Qing Xu, He Huang, Ling Jiang*, Shangtian Yang. Tailoring the oxidative stress tolerance of Clostridium tyrobutyricum CCTCC W428 by introducing trehalose biosynthetic capability. Journal of Agricultural and Food Chemistry. 2017, 65, 8892-8901.
[14]. Yadong Yu, Tao Li, Na Wu, Lujing Ren, Ling Jiang*, Xiaojun Ji*, He Huang*. Mechanism of Arachidonic Acid Accumulation During Aging in Mortierella alpina: A Large-Scale Label-Free Comparative Proteomics Study. Journal of Agricultural and Food Chemistry. 2016, 64, 9124-9134.
[15]. Ling Jiang, Huaiyan Cui, Liying Zhu, Yi Hu, Xian Xu, Shuang Li, He Huang*. Enhanced propionic acid production from whey lactose with immobilized Propionibacterium acidipropionici and role of trehalose synthesis in acid tolerance. Green Chemistry. 2015, 17, 250-259.
[16]. Ling Jiang, Shuang Li, Yi Hu, Qing Xu, He Huang*. Adaptive evolution for fast growth on glucose and the effects on the regulation of glucose transport system in Clostridium tyrobutyricum. Biotechnology and Bioengineering. 2012, 109, 708-718.
[17]. Ling Jiang, Jufang Wang*, Shizhong Liang, Jin Cai, Zhinan Xu*, Peilin Cen, Shangtian Yang, Shuang Li. Enhanced butyric acid tolerance and bioproduction by Clostridium tyrobutyricum immobilized in a fibrous bed bioreactor. Biotechnology and Bioengineering. 2011, 108, 31-40.
[18]. Ling Jiang, Jufang Wang*, Shizhong Liang, Xiaoning Wang, Peilin Cen, Zhinan Xu*. Butyric acid fermentation in a fibrous bed bioreactor with immobilized Clostridium tyrobutyricum from cane molasses. Bioresource Technology. 2009, 100, 3403-3409.
[19]. Ling Jiang, Jin Cai, Jufang Wang*, Shizhong Liang, Zhinan Xu*, Shangtian Yang. Phosphoenolpyruvate-dependent phosphorylation of sucrose by Clostridium tyrobutyricum ZJU 8235: evidence for the phosphotransferase transport system. Bioresource Technology. 2010, 101, 304-309.