喻国灿 - 清华大学

个人简介

Education 2010/09 – 2015/06 Zhejiang University, Ph.D. in Chemistry (Supervisor: Prof. Feihe Huang) 2006/09 – 2010/06 Hefei University of Technology, B.S. in Polymer Materials and Engineering Experience 2020/12 – current Tsinghua University, Assistant Professor 2015/09 – 2020/09 National Institutes of Health, Research Fellow (Supervisor: Dr. Xiaoyuan (Shawn) Chen) Selected Awards 2021 “2021 Highly Cited Researcher” by Clarivate Analytics; “Top 1% Highly Cited Chinese Author List” of RSC journals 2020 “2020 Highly Cited Researcher” by Clarivate Analytics; “Top 1% Highly Cited Chinese Author List” of RSC journals 2019 “Top 1% Highly Cited Chinese Author List” of RSC journals 2015 Outstanding Graduate of Zhejiang Province; Outstanding Graduate of Zhejiang University 2012 Chu Kochen Award of Zhejiang University 2012-2014 National Scholarship

研究领域

Precise supramolecular theranostics We are focusing on the fabrication of novel supramolecular theranostics using artificial macrocycles and natural biomacromolecules as building blocks. mRNA delivery systems and vaccines We are designing and synthesizing novel and patentable ionizable lipids, cationic lipids, cholesterol derivatives, and functional polymers. Supramolecular regulation of tumor microenvironment and tumor metabolism for cancer immunotherapy. We are interested in the development of new supramolecular systems that can be specifically accumulated in tumors to regulate tumor microenvironment and manipulate the metabolism of cancer cells and lymphocytes.

近期论文

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Nat Commun. 2023, 4, 8042.164. A lung-selective delivery of mRNA encoding broadly neutralizing antibody against SARS-CoV-2 infection. Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G. Adv. Mater. 2023, 2304257.163. Engineering Clinically Relevant Probiotics with Switchable "Nano-Promoter" and "Nano-Effector" for Precision Tumor Therapy. Cao F, Jin L, Zhang C, Gao Y, Qian Z, Wen H, Yang S, Ye Z, Hong L, Yang H, Tong Z, Cheng L, Ding Y, Wang W, Yu G, Mao Z, Chen X. JACS Au 2023, 3, 11, 3181–3193.162. Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy. Xinyang Yu, Shaolong Qi, Fangfang Cao, Kai Yang, Hongjian Li, Kun Peng, Zhida Liu*, Bing Bai, Marija Buljan*, Xiaoyuan Chen*, and Guocan Yu* ACS Nano 2023, 17, 23, 23814–23828.161. Poly(ethyl ethylene phosphate): Overcoming the "Polyethylene Glycol Dilemma" for Cancer Immunotherapy and mRNA Vaccination.Xinyang Yu, Hongjian Li, Chunbo Dong, Shaolong Qi, Kai Yang, Bing Bai, Kun Peng, Marija Buljan*, Xin Lin*, Zhida Liu*, and Guocan Yu* Research. 2023, 6, 0211.160. Supramolecular Biomaterials for Cancer Immunotherapy. H Liang, Q Lu, J Yang*, and G Yu* Adv. NanoBiomed Res. 2023, 3, 2200172.159. Stimuli-Responsive Dendritic Supramolecular Vector for Tumor-Specific Gene Delivery. X Ouyang, D Gao, J Shen,* Y Zhou, Y Gao, Y Lv, Q Wang,* G Yu,* and P. K. Chu* Acta Biomater. 2023, 168, 565-579.158. Dynamically assembled nanomedicine based on host−guest molecular recognition for NIR laser-excited chemotherapy and phototheranostics. Dan Wu, Zhankui Zhang, Xinyue Li, Jie Zhou, Yibin Cao, Shaolong Qi, Lei Wang, Zhida Liu, Guocan Yu Adv. Mater. 2023, 2304249.157. Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions. Yan M, Wu S, Wang Y, Liang M, Wang M, Hu W, Yu G, Mao Z, Huang F, Zhou J. J. Am. Chem. Soc. 2023, 145, 34, 18789–18799.156. Supramolecular Modulation of Tumor Microenvironment through Pillar[5]arene-Based Host−Guest Recognition to Synergize Cancer Immunotherapy. Y Feng, S Qi, X Yu, X Zhang, H Zhu*, and G Yu* Org. Lett. 2023, 25, 13, 2289–2293.155. Selective Iodination Enables Anthocyanin Synthesis to Be More General. J Hu, Y Li, G Wu, S Liang, Z Zhao, J Liu, J Chen, G Yu, J Sun, and W Bai* Chem. Soc. Rev. 2023, 52, 2911-2945.154. Polymerization in living organisms. D Wu, J Lei, Z Zhang, F Huang*, M Buljan, G Yu* Small. 2023, 2300217.153. Self‐Assembly of Selenium‐Doped Carbon Quantum Dots as Antioxidants for Hepatic Ischemia‐Reperfusion Injury Management. B Bai, S Qi, K Yang, X Yu, R Jian, T Zhang, D Wang, H Meng, Y Zhao, Y Xia*, H Xu*, G Yu*, Z Chen* Adv. Mater. 2023, 2207875.152. Vesicular Antibodies: Shedding Light on Antibody Therapeutics with Cell Membrane Nanotechnology. C Zhao, Y Pan, G Yu*, XZ Zhao, X Chen*, L Rao* Nano Today. 2023, 49, 101795.151. NIR-II fluorescence lymphatic imaging and intraoperative navigation based on the “isolated cage” monodisperse strategy. S Qi, Y Wang, Y Zhu, X Zhang, X Wang, X Yu, K Yang, B Bai, Y Feng, J Lei, K Zhang, Z Lu, S Zhu*, J Du*, G Yu* Acta Pharm Sin B. 2023, 903-915.150. Lipid nanomaterials-based RNA therapy and cancer treatment. X Zhang*, L Hai, Y Gao, G Yu*,Y Sun* Angew. Chem.Int. Ed. 2022, 61, e202213572.149. Suprasomes Based on Host–Guest Molecular Recognition: An Excellent Alternative to Liposomes in Cancer Theranostics. K Yang, B Hua, S Qi, B Bai, C Yu*, F Huang, G Yu* Sci Bull. 2022, 1898-1909.148. Supramolecular engineering of cell membrane vesicles for cancer immunotherapy. S Qi, H Zhang, X Zhang, X Yu, Y Wang, QF Meng, K Yang, B Bai, R Tian,S. Zhu,* L. Rao,* F. Huang, G. Yu* Theranostics. 2022, 12, 14.147. Circular RNA cancer vaccines drive immunity in hard-to-treat malignancies. H. Li,# K. Peng,# K. Yang, W. Ma, S. Qi, Xinyang Yu, J. He, X. Lin*, G. Yu* Angew. Chem.Int. Ed. 2022, 61, e202203786.146. A Hybrid Supramolecular Polymeric Nanomedicine for Cascade-Amplified Synergetic Cancer Therapy. K. Yang,# S. Qi,# X. Yu, B. Bai, X. Zhang, Z. Mao, F. Huang, G. Yu* Chem. Soc. Rev. 2022, 51, 1336-1376.145. Metal-free bioorthogonal click chemistry in cancer theranostics. D. Wu,*,# K. Yang,# Z. Zhang, Y. Feng, L. Rao,* X. Chen,* G. Yu,* Angew. Chem.Int. Ed. 2022, 61, e202115208.144. Aggregation-Induced Emission Featured Supramolecular Tubisomes for Imaging-Guided Drug Delivery.J. Yang,# X. Yu,# J.-I. Song, Q. Song, S. C. L. Hall, G. Yu, S. Perrier,* J. Nanobiotech. 2022, 20, 24.143. The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery.S. Qi, X. Wang, K. Chang, W. Shen, G. Yu,* J. Du,* Chem. Soc. Rev. 2021, 50, 2839–2891.142. Supramolecular cancer nanotheranostics.J. Zhou,# L Rao,# G. Yu,* X. Chen,* F. Huang,* Angew. Chem. Int. Ed. 2021, 60, 8018–8034.141. Cell Death Mediated by Pyroptosis Pathway with the Help of Nanotechnology: New Prospects for Cancer Therapy.D.Wu,* S. Wang,* G. Yu,* X. Chen,* Adv. Funct. Mater. 2021, 31, 2008078.140. Oxygen-Evolving Manganese Ferrite Nanovesicles for Hypoxia‐Responsive Drug Delivery and Enhanced Cancer Chemoimmunotherapy.K. Yang, # G. Yu,# R. Tian, Z. Zhou, H. Deng,* L. Li, Z. Yang, G. Zhang, D. Liu, J. Wei, L. Yue, R. Wang,* X. Chen,* Adv. Mater. 2021, 34, 2107434.139. Polyprodrug Nanomedicines: An Emerging Paradigm for Cancer Therapy.K. Yang, Z. Yang, G. Yu,* Z. Nie,* R. Wang,* X. Chen,* Angew. Chem. Int. Ed. 2021, 60, 17570–17578.138. Supramolecular Polymerization-Induced Nanoassemblies for Self-Augmented Cascade Chemotherapyand Chemodynamic Therapy of Tumor.K. Yang,# G. Yu,# Z. Yang,L. Yue, X. Zhang,C. Sun,J. Wei,L. Rao,X. Chen*,R Wang* Chem 2021, 7, 3256–3291.137. Artificial transmembrane ion transporters as potential therapeutics.J. Yang,* G. Yu,* J. L. Sessler,* I. Shin,* P. A. Gale,* F. Huang,* J. Nanobiotech. 2021, 19, 330.136. Evaluation of the stability of cucurbit [8] uril-based ternary host− guest complexation in physiological environment and the fabrication of a supramolecular theranostic nanomedicine.H. Wu, Z. Chen,* S. Qi, B. Bai, J. Ye, D. Wu, J. Shen, F. Kang,* G. Yu,* Curr. Opin. Chem. Biol. 2021, 61, 19–31.135. Supramolecular coordination complexes as diagnostic and therapeutic agents.G. Yu,# M. Jiang,# F. Huang,* X. Chen,* Adv. Sci. 2021, 2002927.134. Photodynamic-Chemodynamic Cascade Reactions for Efficient Drug Delivery and Enhanced Combination Therapy.S. Wang, G. Yu, W. Yang, Z. Wang,* O. Jacobson, R. Tian, H. Deng, L. Lin,* X. Chen,* Angew. Chem. Int. Ed. 2021, 60, 21033–21039.133. Exquisite Vesicular Nanomedicine by Paclitaxel Mediated Co-assembly with Camptothecin Prodrug.Z. Zhou,* C. Du, Q. Zhang, G. Yu, F. Zhang,* X. Chen,* Sci. China Chem. 2021, 64, 688–700.132. Pillararene-based supramolecular systems for theranostics and bioapplications.H. Zhu, Q. Li, L. E Khalil-Cruz, N. M Khashab,* G. Yu,* F Huang*, Biomaterials 2021, 275, 120822.131. A hypoxia responsive nanoassembly for tumor specific oxygenation and enhanced sonodynamic therapy.K. Yang, L. Yue, G. Yu, L. Rao, R. Tian, J. Wei, Z. Yang, C. Sun, X. Zhang, M. Xu, Z. Yuan, X. Chen,* R. Wang,*