陈鹏 - 北京大学 - 化学与分子工程学院

个人简介

EDUCATION 2002-2007 Ph.D in Chemistry (2007) University of Chicago Chicago, USA 1998-2002 B.S. in Chemistry, Peking University Beijing, China 1999-2002 B.S. Double degree in Economics, Peking University Beijing, China ACADEMIC POSITIONS 2022/01- present Executive Editor, ACS Chemical Biology, American Chemical Society 2021/05- present Director, Synthetic and Functional Biomolecules Center, Peking University 2020/01-present Director, Division of Chemical Biology, Chinese Chemical Society 2019/03-2021/12 Associate Editor, ACS Chemical Biology, American Chemical Society 2018/01-present, Cheung Kong Professor, Ministry of Education, P.R.China 2016/01-present, Senior Investigator, Peking-Tsinghua Center for Life Science 2015/01-present, Chairman, Department of Chemical Biology, Peking University 2014/08-present, Professor, Department of Chemical Biology, Peking University 2011/05-2015/12, Investigator, Peking-Tsinghua Center for Life Sciences 2009/07-2014/07, Investigator, Department of Chemical Biology, College of Chemistry, Peking University 2007-2009, Postdoctoral Fellow, The Scripps Research Institute, Advisor: Prof. Peter G. Schultz 2002-2007, Research Assistant, The University of Chicago, Chicago. Advisor: Prof. Chuan He

研究领域

Development and application of bioorthogonal chemical reactions on living systems, to provide innovative tools for life science research and develop innovative technologies for diagnostics and therapeutics through the chemical knowledge and tools. 1.Bioorthogonal chemistry and chemical tools development. 2.Protein engineering and omics. 3.Immune chemical biology.

近期论文

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Guo W, Liu Y, Han Y, Tang H, Fan X, Wang C*, Chen P*, "Amplifiable protein identification via residue-resolved barcoding and composition code counting", Natl. Sci. Rev. (2024), https://doi.org/10.1093/nsr/nwae183 Liu, Z.#; Guo, F.#; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen P.*; Fan X.*, Bioorthogonal photocatalytic proximity labeling in primary living samples. Nat. Commun. (2024) 15, 2712. Zhu Y, Ding W, Fan X*, Lin S*, Chen P*, “Genetically encoded bioorthogonal tryptophan decaging in living cells”, Nat. Chem. (2023), under revision. Weng Y, Chen W, Kong Q, Wang R, Zeng R, He A, Liu Y, Mao Y, Qin Y, Ngai WSC, Zhang H, Wang J, Ke M, Tian R*, Chen P*. “DeKinomics pulse-chases kinase functions in living cells”, Nat. Chem. Biol. (2023). Zhang X, Huang H, Liu Y, Wu Z, Wang F, Fan X*, Chen P*, Wang J*, “Optical control of protein functions via genetically encoded photocaged aspartic acids”, J. Am. Chem. Soc. (2023),145, 19218-24. Qin F*, Li B, Wang H, Ma S, et al, Ji X*, Chen P*. “Linking chromatin acylation mark-defined proteome and genome in living cells”, Cell, (2023), 186, 1066-85 Liu Z, Xie X, Huang Z, Lin F, Liu S, Chen Z, Qin S, Fan X*, Chen P*. “Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging”. Chem. (2022), 8, 2179-91 Luo H, Tang W, Liu H, Zeng X, Ngai WSC, Gao R, Li H, Li R, Zheng H, Guo J, Qin F, Wang G, Li K, Fan X*, Zou P*, Chen P*. “Photocatalytic chemical crosslinking for profiling RNA-protein interactions in living cells”, Angew. Chem. Int. Ed. (2022), doi: 10.1002/anie.202202008. Liu H, Luo H, Xue Q, Qin S, Qiu S, Liu S, Lin J, Li JP*. Chen, P*, “Antigen-specific T cell detection via photocatalytic proximity cell labeling (PhoXCELL)”. J. Am. Chem. Soc. (2022),144, 5517-26. Ngai WSC, Yang S, Zeng X, Liu Y, Lin F, Wang X, Zhang H, Fan X*, Chen P*. “Bioorthogonally activatable base editing for on-demand pyroptosis”. J. Am. Chem. Soc. (2022). 144, 5411-17. Han Y, Yang Z, Hu H, Zhang H, Chen L, Li K, Kong L, Wang Q, Liu B, Wang M*, Lin J*, Chen P*. “Covalently engineered protein minibinders with enhanced neutralization efficacy against escaping SARS-CoV-2 variants”. J. Am. Chem. Soc. (2022). 144, 5702-07 Huang Z, Liu Z, Xie X, Zeng R, Chen Z, Kong L, Fan X*, Chen P*. “Bioorthogonal photocatalytic decaging-enabled mitochondrial proteomics”, J. Am. Chem. Soc. (2021), 143, 18714-20 Zhang H, Han Y, Yang Y, Lin F, Lin J*, Chen P*. “Covalently engineered nanobody chimeras for targeted membrane protein degradation”. J. Am. Chem. Soc. (2021),143, 16377-82 Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*. “SAR1B senses leucine levels to regulate mTORC1 signalling”, Nature, (2021), 596, 281-4. Wang J, Liu Y, Liu Y, Wang C*, Chen P*. “CAGE-prox: A unified approach for time- resolved protein activation in living systems”, Curr. Proto., (2021), e180. DOI: 10.1002/cpz1.180. Liu Y, Zeng R, Zou P*, Chen P*. “Spatiotemporally resolved subcellular phosphoproteomics”, Proc. Natl. Acad. Sci. USA. (2021), 118, e2025299118. Yang S, Ngai WSC, Chen P*. “Chemical engineering of bacterial effectors for regulating cell signaling and responses”, Curr Opin Chem Biol. (2021), 64, 48-56. Wang, J, Wang, X. Fan, X*. Chen P*. “Unleashing the power of bond cleavage chemistry in living systems”, ACS Cent. Sci. (2021), 7, 929-43. Liu S, Lin C, Xu Y, Luo H, Peng L, Zeng X, Zheng X, Chen P*, Zou P*. “A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons”, Nat. Chem. (2021), 13,472-9 Zhu R, Zhang G, Jing M, Han Y, Li J, Zhao J, Li Y, Chen P*. “Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction”, Nat. Commun. (2021), 12, 581. Zhang X, Luo H, Fan X*, Chen P*. “Development and application of inverse-electron-demand Diels-Alder reaction in biorthogonal chemistry”. Sci. Sin. Chim. (2020), 50,1280-95. Chen L, Liu B, Sun P, Wang W, Luo S, Zhang W, Yang Y, Wang Z, Lin J*, Chen P*. “Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Nanogel as a Pro-Antigen Strategy with Enhanced Protective Immune Responses”. Small. (2020), 16, e2004237. Li J, Wang YN, Xu BS, Liu YP, Zhou M, Long T, Li H, Dong H, Nie Y, Chen P, Wang ED*, Liu RJ*. “Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs”. EMBO Rep. (2020), 21, e50095. Yu R, Wu H, Ismail H, Du S, Cao J, Wang J, Ward T, Yang F, Gui P, Ali M, Chu L, Mo F, Wang Q, Chu Y, Zang J, Zhao Y, Ye M, Fang G, Chen P, Dou Z, Gao X, Wang W, Liu X, Yao X. “Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics”. J Mol Cell Biol. (2020), 12, 462-76 Yang S, Tang Q, Chen L, Chang J, Zhao J,Jiang T, Wang M,* Chen P*. “Cationic Lipid-based Intracellular Delivery of Bacterial Effectors for Rewiring Malignant Cell Signaling”, Angew. Chem. Int. Ed. (2020), 59, 18087-94. Zheng H, Lin S, Chen P*. “Genetically encoded protein labeling and crosslinking in living Pseudomonas aeruginosa”. Bioorg Med Chem. (2020), 28, 115545 Song H, Wang Y, Wang R, Zhang X, Liu Y, Jia G, Chen P*. “SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference”, Cell Chem. Biol. (2020), 27, 283-91. Wang J, Liu Y, Liu Y, Zheng S, Wang X, Zhao J, Yang F, Zhang G, Wang C*, Chen P*. “Time-resolved protein activation by proximal decaging in living systems”，Nature. (2019), 569, 509–513. Ge Y, Chen L, Liu S, Zhao J, Zhang H, Chen P*. “Enzyme-mediated intercellular proximity labeling for detecting cell-cell interactions”，J. Am. Chem. Soc. (2019), 141, 1833-37. Zhao J, Liu Y, Lin F, Wang W, Yang S, Ge Y, Chen P*. “Bioorthogonal Engineering of Bacterial Effectors for Spatial–Temporal Modulation of Cell Signaling”, ACS Cent. Sci. (2019), 5, 145-53. He D, Zhang M, Liu S, Xie X, Chen P*. “Protease-mediated protein quality control for bacterial acid resistance”, Cell Chem. Biol. (2019), 26,144-50.