Leggio, Leila Lo - University of Copenhagen

个人简介

July 1993: First class Honours Degree from the University of Bath, UK (professional placements at Babraham Institute, Cambridge, UK and Max-Planck Institute, Martinsried, München, Germany). March 1997: PhD obtained at Institute of Food Research, Reading, UK/Birkbeck College, London, April 1997-July 2003: Postdoctoral employment at Centre for Crystallographic Studies, Department of Chemistry, University of Copenhagen (funded by the Danish National Research Foundation, the EU and EMBO). August 2003-February 2018: Associate professor at the Department of Chemistry, University of Copenhagen. 2005-2012: Group leader of Biophysical Chemistry Group, Department of Chemistry, University of Copenhagen(Integrated in the Biophysical and Bioinorganic Chemistry Section in 2012) From Jan 2016: Section Leader, Biological Chemistry section From March 2018: Professor at the Department of Chemistry, University of Copenhagen 72 published or accepted peer reviewed articles, reviews and conference proceedings, 12 as first author, 31 as corresponding author. 10 additional publications 2818 Web of Science (WoS) and 4311 Google Scholar (GS) citations, 41 cites/article on WoS, H-I of 22 from WoS and 28 from GS, i10index from GS of 49, i100 index from GS of 1 Author of 86 PDB entries

研究领域

Structure-function relationship in proteins, with recent focus mainly on carbohydrate-active protein, DNA-binding transcription factors and protein engineering/design. X-ray crystallography and more recently small angle scattering are the main techniques used.

近期论文

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Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA Varming, Anders Kokkenborg, Rasmussen, K. K., Zong, Zhiyou, Thulstrup, Peter Waaben, Kilstrup, M. & Lo Leggio, Leila, 2022, In: FEBS Journal. 289, 4, p. 1135-1148 14 p. Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans Muderspach, Sebastian Jannick, Fredslund, F., Volf, V., Poulsen, Jens-Christian Navarro, Blicher, T. H., Clausen, M. H., Rasmussen, K. K., Krogh, K. B. R. M., Jensen, K. & Lo Leggio, Leila, 1 Dec 2021, In: Biotechnology for Biofuels. 14, 1, 16 p., 183. Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans Kristensen, C. S., Varming, Anders Kokkenborg, Leinweber, Helena Augusta Katharina, Hammer, K., Lo Leggio, Leila, Ingmer, Hanne & Kilstrup, M., 1 Oct 2021, In: MicrobiologyOpen. 10, 5, 22 p. Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii Krska, D., Mazurkewich, S., Brown, H. A., Theibich, Yusuf, Poulsen, Jens-Christian Navarro, Morris, A. L., Koropatkin, N. M., Lo Leggio, Leila & Larsbrink, J., 13 Jul 2021, In: Biochemistry. 60, 27, p. 2206-2220 15 p. Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan Sprenger, J., Lawson, C. L., Von Wachenfeldt, C., Lo Leggio, Leila & Carey, J., 1 Jul 2021, In: Acta Crystallographica Section F: Structural Biology Communications. 77, 7, p. 215-225 11 p. Probing the determinants of the transglycosylation/hydrolysis partition in a retaining α-L-arabinofuranosidase Zhao, J., Tandrup, T., Bissaro, B., Barbe, S., Poulsen, Jens-Christian Navarro, André, I., Dumon, C., Lo Leggio, Leila, O'Donohue, M. J. & Fauré, R., 25 May 2021, In: New Biotechnology. 62, p. 68-78 11 p. Estimating the accuracy of calculated electronparamagnetic resonance hyperfine couplings for alytic polysaccharide monooxygenase Theibich, Y. A., Sauer, Stephan P. A., Lo Leggio, Leila & Hedegård, E. D., 12 Jan 2021, In: Computational and Structural Biotechnology Journal. 19, p. 555-567 13 p. Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs) Frandsen, Kristian Erik Høpfner, Haon, M., Grisel, S., Henrissat, B., Lo Leggio, Leila & Berrin, J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 11 p., 100086. Calmodulin complexes with brain and muscle creatine kinase peptides Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., Rowlett, R., Lo Leggio, Leila, Åkerfeldt, K. S. & Linse, S., 2021, In: Current Research in Structural Biology. 3, p. 121-132 12 p. Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects Mishra, Narendra Kumar, Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, Shunliang, Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 18, p. 8467–8473 7 p. Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC Ipsen, Johan Ørskov, Hernández‐Rollán, C., Muderspach, Sebastian Jannick, Brander, Søren, Bertelsen, A. B., Jensen, Poul Erik, Nørholm, M. H. H., Lo Leggio, Leila, Johansen, Katja Salomon & Ferguson, S. (ed.), 2021, In: FEBS Letters. 595, 12, p. 1708-1720 13 p. Guest-protein incorporation into solvent channels of a protein host crystal (hostal) Sprenger, J., Carey, J., Schulz, Alexander, Drouard, F., Lawson, C. L., Von Wachenfeldt, C., Linse, S. & Lo Leggio, Leila, 2021, In: Acta crystallographica Section D: Structural biology . 77, p. 471-485 15 p. Inhibition of lytic polysaccharide monooxygenase by natural plant extracts Tokin, Radina, Frandsen, Kristian Erik Høpfner, Ipsen, Johan Ørskov, Lo Leggio, Leila, Poojary, Mahesha Manjunatha, Berrin, J., Grisel, S., Brander, Søren, Jensen, Poul Erik & Johansen, Katja Salomon, 2021, In: New Phytologist. 232, 3, p. 1337–1349 13 p. Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications Ipsen, Johan Ørskov, Hallas-Møller, Magnus, Brander, Søren, Lo Leggio, Leila & Johansen, Katja Salomon, 2021, In: Biochemical Society Transactions. 49, 1, p. 531-540 10 p. Scission of Glucosidic Bonds by a Lentinus similis Lytic Polysaccharide Monooxygenases Is Strictly Dependent on H2O2while the Oxidation of Saccharide Products Depends on O2 Brander, Søren, Tokin, Radina, Ipsen, Johan Ørskov, Jensen, Poul Erik, Hernández-Rollán, C., Nørholm, M. H. H., Lo Leggio, Leila, Dupree, P. & Johansen, Katja Salomon, 2021, In: ACS Catalysis. 11, 22, p. 13848-13859 Biochemical evidence of both copper chelation and oxygenase activity at the histidine brace Brander, Søren, Horvath, I., Ipsen, Johan Ørskov, Peciulyte, A., Olsson, L., Hernández-rollán, C., Nørholm, M. H. H., Mossin, S., Lo Leggio, Leila, Probst, C., Thiele, D. J. & Johansen, Katja Salomon, 1 Dec 2020, In: Scientific Reports. 10, 1, 11 p., 16369. Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage Rasmussen, K. K., Palencia, A., Varming, Anders Kokkenborg, El-Wali, H., Erba, E. B., Blackledge, M., Hammer, K., Herrmann, T., Kilstrup, M., Lo Leggio, Leila & Jensen, M. R., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20576-20585 10 p. Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator Pedersen, M., Neergaard, J. T., Cassias, J., Rasmussen, K. K., Lo Leggio, Leila, Sneppen, Kim, Hammer, K. & Kilstrup, M., 26 May 2020, In: Scientific Reports. 10, 1, 13 p., 8659. An 1,4-α-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus Andersen, S., Møller, M. S., Poulsen, Jens-Christian Navarro, Pichler, M. J., Svensson, B., Lo Leggio, Leila, Goh, Y. J. & Abou Hachem, M., 22 May 2020, In: Applied and Environmental Microbiology. 86, 15, 14 p., e00661-20. A fungal family of lytic polysaccharide monooxygenase-like copper proteins Labourel, A., Frandsen, Kristian Erik Høpfner, Zhang, Liying, Brouilly, N., Grisel, S., Haon, M., Ciano, L., Ropartz, D., Fanuel, M., Martin, F., Navarro, D., Rosso, M., Tandrup, T., Bissaro, B., Johansen, Katja Salomon, Zerva, A., Walton, P. H., Henrissat, B., Lo Leggio, Leila & Berrin, J., 2020, In: Nature Chemical Biology. 16, p. 345-350 11 p.