侯卫 - 浙江工业大学

个人简介

教育经历 2011-9至2016-6, 中国科学院上海药物研究所, 药物化学, 博士, 导师: 李援朝 2007-9至2011-6, 郑州大学, 药学, 学士，导师: 刘宏民工作经历 2020-12至现在, 浙江工业大学, 药学院, 副研究员 2018-12至2020-12, 浙江工业大学, 药学院, 校聘副教授 2016-10至2018-11, 浙江工业大学, 博士后, 合作导师: 阮奔放

研究领域

（1）微量元素硒的药物化学生物学（2）DNA编码化合物库的设计、构建与筛选（3）以临床需求为导向的创新药物研究。在含硒药物、核苷类药物的设计、合成和优化方面积累了丰富的经验。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xu, H.;*# Wang, Y.;# Dong, H.; Zhang, Y.; Gu, Y.; Zhang, S.; Meng, Y.; Li, J.; Shi, X.; Ji, Q.; Liu, L.; Ma, P.;Ma, F.;*Yang, G.;*Hou, W.* Selenylation Chemistry Suitable for On-Plate Parallel and On-DNA Library Synthesis Enabling High-Throughput Medicinal Chemistry. Angew. Chem. Int. ed. 2022, 61, e202206516. (通讯作者，Hot Paper, back cover, IF: 15.336，中科院一区，Top期刊) [link] Xu, H.;# Gu, Y.;# Zhang, S.; Xiong, H.; Ma, F.; Lu, F.; Ji, Q.; Liu, L.; Ma, P.; Hou, W.;* Yang, G.;* Lerner, R. A.*A Chemistry for Incorporation of Selenium into DNA-Encoded Libraries. Angew. Chem. Int. ed. 2020, 59, 13273-13280. (通讯作者，VIP Paper, inside back cover, IF: 15.336，中科院一区，Top期刊，Times cited: 15) [link] Hou, W.;* Xu, H.* Incorporating selenium into heterocycles and natural products — from chemical properties to pharmacological activities. J. Med. Chem. 2022, 65, 10.1021/acs.jmedchem.1c01859. (第一作者&通讯作者，IF: 7.446，中科院一区，Top期刊，Invited Perspective) [link] Hou, W.;* Dong, H.; Zhang, X.;* Wang, Y.; Su, L.; Xu, H.*Selenium as an emerging versatile player in heterocycles and natural products modification. Drug. Discov. Today. 2022, 27, 2268-2277.(第一作者&通讯作者，IF:7.851，中科院一区，Top期刊，Invited MiniReview) Hou, W.; Luo, Z.; Zhang, G.; Cao, D.; Li, D.; Ruan, H.; Ruan, B. H.; Su, L.;* Xu, H.* Click chemistry-based synthesis and anticancer activity evaluation of novel C-14 1,2,3-triazole dehydroabietic acid hybrids. Eur. J. Med. Chem. 2017, 138, 1042-1052. (第一作者，IF: 6.514，中科院一区，Top期刊，Times cited: 35). [link] Xiong, H.; Gu, Y.; Zhang, S.; Lu, F.; Ji, Q.; Liu, L.; Ma, P.; Yang, G.; Hou, W.;* Xu, H.* Iridium- Catalyzed C-H Amidation of s-Tetrazines. Chem. Commun. 2020, 56, 4692-4695. (通讯作者，IF: 6.164，中科院二区，Top期刊，Times cited: 14). [link] Hou, W.;* Liu, B.;* Xu, H.* Celastrol: Progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. Eur. J. Med. Chem.2020, 189, 112081. (第一作者&通讯作者，IF: 6.514，中科院一区，Top期刊，高被引论文，Times cited: 44). [link] Hou, W.; Liu, B.;* Xu, H.* Triptolide: Medicinal chemistry, chemical biology and clinical progress. Eur. J. Med. Chem.2019, 176, 378-392. (第一作者，IF: 6.514，中科院一区，Top期刊，Times cited: 56). [link] Zhang, X.;* Bai, R.; Xiong, H.; Xu, H.;*Hou, W.*Meeting Organometallic Chemistry with Drug Discovery: C-H activation Enabled Discovery a new ring system of 12H-Indazolo[2,1-a]cinnolin-12-ones with Anti-proliferation Activity. Bioorg. Med. Chem. Lett.2020, 30, 126916. (通讯作者，IF: 2.823，中科院三区，Times cited: 4). [link] Su, L.; Zheng, Y.; Ren, P.; Luo, Z.; Hou, W.;*Xu, H.* Ruthenium(II)-catalyzed synthesis of indazolonefused cinnolines via C–H coupling with diazo compounds. Org. Biomol. Chem.2018, 16, 7236-7244. (通讯作者，IF: 3.876，中科院三区，Top期刊，Times cited: 27). [link] Hou, W.; Yang, Y.; Wu, Y.; Feng, H.; Li, Y.; Zhou, B.*Rhodium(III)-catalyzed alkylation of primary C(sp3)–H bonds with a-diazocarbonyl Compounds.Chem. Commun. 2016, 52, 9672-9675. (第一作者，IF: 6.164，中科院二区，Top期刊，Times cited: 53). [link]