Christmann, Mathias - Freie Universität Berlin

个人简介

Education 2007 Venia Legendi in Organic Chemistry, RWTH Aachen, Germany 2001 Dr. rer. nat. with Prof. M. Kalesse, Leibniz University Hannover, Germany 1998 Diploma in Chemistry, TU Braunschweig, Germany Academic Career since 2013 Full Professor (W3), Freie Universität Berlin, Germany 2008-2013 Associate Professor (W2), TU Dortmund University, Germany 2003-2007 Habilitand, RWTH Aachen, Germany 2001-2002 Postdoctoral Associate at the University of Minnesota with Prof. C. J. Forsyth, Minneapolis, MN, USA Awards 2013 Carl Duisberg Memorial Prize 2012 DECHEMA Young Scientist Award for Natural Products Research 2009 Docent Fellowship of the Fonds der Chemischen Industrie 2003 Liebig Fellowship of the Fonds der Chemischen Industrie

研究领域

Organic synthesis constitutes the enabling science for the creation of new compositions of matter with ramifications for material’s science, medicine and biology. Our research program is dedicated to the understanding and modulation of biologically relevant pathways with small molecules.

近期论文

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Semisynthesis of Plant-Derived Englerin A Enabled by Microbe Engineering of Guaia-6,10(14)-diene as Building Block T. Siemon, Z. Wang, G. Bian, T. Seitz, Z. Ye, Y. Lu, S. Cheng, Y. Ding, Z. Deng, T. Liu, M. Christmann J. Am. Chem. Soc. 2020, 142, DOI: 10.1021/jacs.9b12940. Scalable Synthesis of Functionalized Ferrocenyl Azides and Amines Enabled by Flow Chemistry M. Kleoff, J. Schwan, L. Boeser, B. Hartmayer, M. Christmann, B. Sarkar, P. Heretsch Org. Lett. 2020, 22, DOI: 10.1021/acs.orglett.9b04450. Five‐Step Synthesis of Yaequinolones J1 and J2 J. Schwan, M. Kleoff, P. M. Heretsch, M. Christmann Org. Lett. 2020, 22, 675–678. Synthesis of spongidine A, D and petrosaspongiolide L methyl ester using pyridine C-H functionalization F. Bartels, M. Weber, M. Christmann Org. Lett 2020, 22, 552–555 NHS-modified ethynylphosphonamidates enable the synthesis of configurationally defined protein conjugates M.-A. Kasper, M. Gerlach, A. Schneider, C. Groneberg, S. Boldt, P. Ochtrop, D. Schumacher, J. Helma, H. Leonhardt, M. Christmann, C. P. R. Hackenberger ChemBioChem 2019, 20, 113–119. Protein Modification of Lysine with 2-(2-Styrylcyclopropyl)ethanal C. Apel, M.‐A. Kasper, C. Stieger, C. P. R. Hackenberger, M. Christmann Org. Lett 2019, 21, 10043–10047. Probing 2H‐Indazoles as Template for SGK1, Tie2 and SRC Kinase Inhibitors J. Schoene, T. Gazzi, P. Lindemann, M. Christmann, A. Volkamer, M. Nazaré ChemMedChem 2019, 14, 1514–1527. Synthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre‐functionalized Dipyrromethanes B. F Hohlfeld, K. J. Flanagan, N. Kulak, M. O. Senge, M. Christmann, A. Wiehe Eur. J. Org. Chem 2019, 4020–4033. Dienamine-Induced Divinylcyclopropane-Cycloheptadiene Rearrangements C. Apel, S. S. Hartmann, D. Lentz, M. Christmann Angew. Chem. Int. Ed. 2019, 58, 5075–5079. Synthesis of (+)-Darwinolide, a Biofilm-Penetrating Anti-MRSA Agent T. Siemon, S. Steinhauer. M. Christmann Angew. Chem. Int. Ed. 2019, 58, 1120–1122.Highlighted as HOT PAPER in Synfacts 2019, 15, 114. Formal Synthesis of Actinoranone Using a Racemization-Free One-Pot Semipinacol Rearrangement/Wittig Reaction M. Menger, M. Christmann Tetrahedron 2019, 75, 10–16. Synthesis of Quinolinone Alkaloids via Aryne Insertions into Unsymmetric Imides in Flow J. Schwan, M. Kleoff, B. Hartmayer, P. Heretsch, M. Christmann Org. Lett. 2018, 20, 7661–7664.featured in Org. Process Res. Dev. 2019, 23, 289. Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis R. Driller, S. Janke, M. Fuchs, E. Warner, A. R. Mhashal, D. T. Major, M. Christmann, T. Brück, B. Loll Nat. Commun. 2018, 9, 3971. Synthesis of Enantioenriched Bromohydrins via Divergent Reactions of Racemic Intermediates from Anchimeric Oxygen Borrowing Y.-M. Cao, D. Lentz, M. Christmann J. Am. Chem. Soc. 2018, 140, 10677–10681. Synthesis of Highly Enantioenriched Propelladienes and their Application as Ligands in Asymmetric Rh-Catalyzed 1,4-Additions T. Pecchioli, M. Christmann Org. Lett. 2018, 20, 5256–5259. Enabling strategies for step efficient syntheses J. Schwan, M. Christmann Chem. Soc. Rev. 2018, 47, 7985–7995.Mechanistic Studies on the Organocatalytic α‐Chlorination of Aldehydes: The Role and Nature of Off‐Cycle Intermediates S. Ponath, M. Menger, L. Grothues, M. Weber, D. Lentz, C. Strohmann, M. Christmann Angew. Chem. Int. Ed. 2018, 57, 11683–11687. Synthesis of (+)-Vitepyrroloid A and (+)-Vitepyrroloid B by Late-Stage Ni-Catalyzed C(sp2)-C(sp3) Cross-Electrophile Coupling M. Menger, D. Lentz, M. Christmann J. Org. Chem. 2018, 83, 6793–6797. TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (–)-Englerin A S. Y. Cheung, M. Henrot, M. Al-Saad, M. Baumann, H. Müller, A. Unger, H. Rubaiy, I. Mathar, K. Dinkel, P. Nussbaumer, B. Klebl, M. Freichel, B. Rode, S. Trainor, S. Clapcote, M. Christmann, H. Waldmann, S. Abbas, D. Beech, N. Vasudev Oncotarget 2018, 9, 9, 29634–29643. A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus-Silane System J. Schoene, H. Bel Abed, P. Schmieder, M. Christmann, M. Nazaré Chem. Eur. J. 2018, 23, 9090–9100.