林兆宇 - 南京大学 - 模式动物研究所

个人简介

2006-2012年在南京大学模式动物研究所攻读博士学位，师从高翔教授，并在美国圣路易斯华盛顿大学进行3年访问学者研究。回国后2012-2013年在南京大学化学化工学院进行博士后研究；2014年加入模式动物研究所任副研究员；2019年受聘为南京大学副教授，医药生物技术国家重点实验室研究员。基金种类　基金项目名称国家科技部重点研发计划2018YFA0801100发育编程及其代谢调节江苏省自然科学基金BK20181260GSMDA/Gsdma3在表皮稳态维持中的作用机制研究国家自然科学基金31301217脂肪酸代谢调节重编程的研究

研究领域

本课题组专注于生理稳态的免疫和代谢调控。由于免疫和代谢涉及几乎所有的核心生理稳态调控，所以其调控紊乱是自身免疫、肥胖、不孕不育、肿瘤、心血管和老年痴呆等多种复杂疾病的重要原因。本课题组希望从分子机制角度解释免疫和代谢紊乱导致的复杂疾病的症状，并探寻疾病临床治疗靶点和方法。围绕着生理稳态的免疫和代谢调控本课题组开展了以下三方面的研究内容： (一) 固有免疫中细胞焦亡与相关自身疾病（脓毒症、矽肺、哮喘和银屑病等）的发病机制研究和治疗方法开发 (二) 机体代谢紊乱（肥胖）的调控机制研究与相应减肥疗法的开发 (三) 基于肠道菌群人源化小鼠模型研究炎症性肠病和结肠癌的发病机制和治疗方法

近期论文

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1. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652. 2. Zheng, J., D. Wang, Q. Chen, Q. Liu, Z. Lin, Q. Hu, X. Wu, X. Gao, Q. Li, and J. Ren, Hypertonic saccharide solution delays pyroptosis in murine macrophages regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol, 2020. 50(3): p. 464-467. 3. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481. 4. Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020. 5. Zhang, X., Q. Xia, R. Wei, H. Song, J. Mi, Z. Lin, Y. Yang, Z. Sun, and K. Zou, Melatonin protects spermatogonia from the stress of chemotherapy and oxidation via eliminating reactive oxidative species. Free Radic Biol Med, 2019. 137: p. 74-86. 6. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082. 7. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren*, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508. 8. Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052. 9. Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639. 10. Luan, X.R., X.L. Chen, Y.X. Tang, J.Y. Zhang, X. Gao, H.P. Ke, Z.Y. Lin, and X.N. Zhang, CRISPR/Cas9-Mediated Treatment Ameliorates the Phenotype of the Epidermolytic Palmoplantar Keratoderma-like Mouse. Mol Ther Nucleic Acids, 2018. 12: p. 220-228. 11. Lin, Z.*, F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47. 12. Lai, B., J. Zou, Z. Lin, Z. Qu, A. Song, Y. Xu, and X. Gao, Haploinsufficiency of hnRNP U Changes Activity Pattern and Metabolic Rhythms. Am J Pathol, 2018. 188(1): p. 173-183. 13. Song, A., S. Jiang, Q. Wang, J. Zou, Z. Lin, and X. Gao*, JMJD3 Is Crucial for the Female AVPV RIP-Cre Neuron-Controlled Kisspeptin-Estrogen Feedback Loop and Reproductive Function. Endocrinology, 2017. 158(6): p. 1798-1811. 14. Tang, A., P. Shi, A. Song, D. Zou, Y. Zhou, P. Gu, Z. Huang, Q. Wang, Z. Lin*, and X. Gao*, PP2A regulates kinetochore-microtubule attachment during meiosis I in oocyte. Cell Cycle, 2016. 15(11): p. 1450-61. 15. Lyu, Y.S., P.L. Shi, X.L. Chen, Y.X. Tang, Y.F. Wang, R.R. Liu, X.R. Luan, Y. Fang, R.H. Mei, Z.F. Du, H.P. Ke, E. Matro, L.E. Li, Z.Y. Lin, J. Zhao, X. Gao, and X.N. Zhang, A Small Indel Mutant Mouse Model of Epidermolytic Palmoplantar Keratoderma and Its Application to Mutant-specific shRNA Therapy. Mol Ther Nucleic Acids, 2016. 5: p. e299. 16. Jiang, S., Q. Wang, Z. Huang, A. Song, Y. Peng, S. Hou, S. Guo, W. Zhu, S. Yan, Z. Lin*, and X. Gao*, Gastric Bypass Surgery Reverses Diabetic Phenotypes in Bdnf-Deficient Mice. Am J Pathol, 2016. 186(8): p. 2117-2128. 17. Hou, S., L. Xian, P. Shi, C. Li, Z. Lin*, and X. Gao*, The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice. Sci Rep, 2016. 6: p. 26735. 18. Xian, L., S. Hou, Z. Huang, A. Tang, P. Shi, Q. Wang, A. Song, S. Jiang, Z. Lin, S. Guo, and X. Gao, Liver-specific deletion of Ppp2calpha enhances glucose metabolism and insulin sensitivity. Aging (Albany NY), 2015. 7(4): p. 223-32. 19. Shi, P., A. Tang, L. Xian, S. Hou, D. Zou, Y. Lv, Z. Huang, Q. Wang, A. Song, Z. Lin, and X. Gao, Loss of conserved Gsdma3 self-regulation causes autophagy and cell death. Biochem J, 2015. 468(2): p. 325-36.