甘振继 - 南京大学 - 模式动物研究所

个人简介

中组部 “青年千人计划”入选者（2015）。2008年获得中科院上海生命科学研究院博士学位，师从刘勇教授。随后在美国Sanford-burnham医学研究所Daniel P. Kelly教授实验室进行博士后训练。于2013年底全职回到南京大学建立了“骨骼肌线粒体代谢”实验室，研究方向为线粒体代谢重塑与疾病发生。主要研究成果以通讯作者在J Clin Invest.、PNAS、EMBO Mol Med.(封面故事)、Cell Reports、Cell Research等期刊上发表论文9篇；以第一作者在J Clin Invest.、Genes & Development 等期刊上发表多篇论文。曾获得美国心脏学会（AHA）博士后奖学金(2011)，获得AHA 的Louis and Arnold Katz Basic Science Award基础研究青年学者奖（2012）,入选江苏省“双创人才”（2016）、江苏省“杰出青年”（2017）、国家“优青”（2019）。目前承担了包括国家973计划、国自然面上项目在内的多项研究课题。基金种类基金项目名称青年千人计划　骨骼肌代谢的分子调控机制国家重点基础研究发展计划（973计划）2015CB856300靶向线粒体代谢的分子探测与过程调控国家自然科学基金面上项目31471110核受体/miRNA通路在肌肉线粒体能量代谢中的功能和分子机制研究国家自然科学基金面上项目31771291miR-499/Fnipl通路在骨骼肌线粒体质量控制与代谢疾病中的功能机制研究国家自然科学基金重大研究计划培育项目91857105线粒体蛋白质稳态控制在骨骼肌-脂肪间代谢交流中的功能机制研究国家自然科学基金优秀青年项目31922033骨骼肌代谢重塑与疾病国家重点研发计划2018YFA0800704应激对组织器官代谢稳态和发育的调控作用与机制江苏省基础研究计划杰出青年项目BK20170014重要细胞器之间的交互对话在代谢稳态平衡中的功能及其调控机制

研究领域

线粒体重塑与代谢疾病。主要是运用基因工程小鼠为模式动物，通过分子细胞生物学手段探索包括肥胖症、糖尿病与慢性肌肉病在内的代谢疾病发生的分子机制。主要的研究方向有：1）骨骼肌线粒体代谢重塑与疾病的发生；2）利用全基因组染色体状态谱动态分析及代谢组学分析的方法，研究运动代谢的分子基础；3）重要细胞器的交互对话在代谢稳态调节中的作用机制

近期论文

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He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 2021;131(17):e143737. Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X, Gan Z*. AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genet. 2021; 17(3):e1009488. Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z*. Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest. 2020 Jun 16:136155. doi: 10.1172/JCI136155. Chen X, Gao YQ, Zheng YY, Wang W, Wang P, Liang J, Zhao W, Tao T, Sun J, Wei L, Li Y, Zhou Y, Gan Z, Zhang X, Chen HQ, Zhu MS*. The intragenic microRNA miR199A1 in the dynamin 2 gene contributes to the pathology of X-linked centronuclear myopathy. J Biol Chem. 2020; 295(26):8656-8667. Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*. Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785. Xu Z, Fu T, Guo Q, Sun W, Gan Z*. Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity. Pharmacol Res. 2018; 141:176-180. Zhu Z, Wang Z, Zhang C, Wang Y, Zhang H, Gan Z, Guo Z, Wang X. Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism. Chem Sci. 2019; 10(10):3089-3095. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research. 2018; 28(10): 969-980. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose crosstalk to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372. Ma Y, Sun L, Li J, Hu Y, Gan Z, Zong G, Zheng H, Jin Q, Li H, Hu FB, Zeng R, Sun Q, Lin X. Erythrocyte PUFAs, circulating acylcarnitines, and metabolic syndrome risk: a prospective study in Chinese. J Lipid Res. 2019; 60(2):421-429. Yang J, Cao Q, Zhang H, Hao L, Zhou D, Gan Z, Li Z, Tong YX, Ji LN, Mao ZW. Targeted reversal and phosphorescence lifetime imaging of cancer cell metabolism via a theranostic rhenium (I)-DCA conjugate. Biomaterials. 2018; 176:94-105. Yang J, Zhao JX, Cao Q, Hao L, Zhou D, Gan Z, Ji LN, Mao ZW. Simultaneously Inducing and Tracking Cancer Cell Metabolism Repression by Mitochondria-Immobilized Rhenium (I) Complex. ACS Appl Mater Interfaces. 2017; 9(16):13900-13912. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med. 2016; 8(10):1212-1228. Cover story. Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu J, Lai L, Kong Y, Xie H, Yi F, Lai L, Vega R, Kelly DP, Smith SR, Gan Z*. Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J. Biol. Chem. 2016; 291(49):25306-25318. Kong Y*, Li K, Fu T, Wan C, Zhang D, Song H, Zhang Y, Liu N, Gan Z*, Yuan L*. Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression. Oncotarget. 2016; 7(42):67716-67731. Liu J, Liang X, Gan Z*. Transcriptional regulatory circuits controlling muscle fiber type switching. Sci China Life Sci. 2015; 58(4):321-7. Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan Z, Gao X, Chen HQ, Zhu MS. Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci USA. 2015; 112(44):13627-32. Kong Y, Liang X, Liu L, Zhang D, Wan C, Gan Z, Yuan L. High throughput sequencing identifies microRNAs mediating α-synuclein toxicity by targeting neuroactive-ligand receptor interaction pathway in early stage of drosophila parkinson's disease model. PLoS One. 2015; 10(9):e0137432. Gan Z, Rumsey J, Hazen BC, Lai L, Leone TC, Vega RB, Xie H, Conley KE, Auwerx J, Smith SR, Olson EN, Kralli A, Kelly DP. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism. J Clin Invest. 2013; 123(6):2564-75. Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y. A role for protein inhibitor of activated STAT 1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors. J Biol Chem. 2012; 287(45):37973-85. Gan Z, Burkart-Hartman EM, Han DH, Finck B, Leone TC, Smith EY, Ayala JE, Holloszy J, Kelly DP. The nuclear receptor PPARb/d programs muscle glucose metabolism in cooperation with AMPK and MEF2. Genes Dev. 2011; 25(24):2619-30. Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y. c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. PLoS One. 2012; 7(11):e48611. George CX, Gan Z, Liu Y, Samuel CE. Adenosine deaminases acting on RNA, RNA editing, and interferon action (invited review). J Interferon Cytokine Res. 2011; 31(1):99-117. Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W, Liu Y. Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J. 2010; 24(10):3720-32. Gan Z, Zhao L, Yang L, Huang P, Zhao F, Li W, Liu Y. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells. J Biol Chem. 2006; 281(44):33386-94.