陈贵泉 - 南京大学 - 模式动物研究所

个人简介

先后在Journal of Neuroscience、PNAS 和Nature等刊物上发表论文二十篇。于2005年在爱丁堡大学神经科学系获得博士学位。之后分别在哈佛大学和爱丁堡大学开展博士后研究。他于2012年正式加入南京大学模式动物研究所建立神经退行与神经发育相关疾病实验室。实验室的长期目标是阐明老年痴呆症和小颅畸形等疾病发病的分子机制。实验室主要采用小鼠遗传学、分子生物学、细胞和行为神经科学等多学科技术来研究上述科学问题。发现这些神经系统相关疾病病发的分子机制有助于找到新的治疗靶点用于预防和治疗。

研究领域

陈贵泉实验室长期从事神经退行疾病和神经发育缺陷疾病的发病机理的研究。临床研究的证据表明老年痴呆症和小颅畸形症的产生与γ-secretase信号通路及PI3I-Akt信号通路有密切的遗传学联系。我们主要以分子生物学和小鼠遗传学等手段研究早老素和早老素相关蛋白，以及PDK1和Akt等PI3K通路上的基因调控神经干细胞增殖分化、调控大脑皮层发育以及调节成年大脑内神经元存活的分子细胞机制

近期论文

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1. Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y*,Chen G*. Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1 Journal of Neuroscience 12 Aug. 2021: JN-RM-2432-20. 2. Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y*, Chen G*. Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system. Journal of Neuroscience 2021 (41):4976-4990. 3. Wang Q, Gong L, Mao S, Yao C, Liu M, Wang Y, Yang J, Yu B, Chen G*, Gu X*. Klf2-Vav1-Rac1 axis promotes axon regeneration after peripheral nerve injury. Experimental Neurology 2021 (343):113788. 4. Wang H，Liu M，Zou G，Wang L, Duan W，He X, Ji M，Zou X, Hu Y*, Yang J*，Chen G*. Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system. Neurobiology of Disease 2021 (148): 105212. 5. Wu J, Shao C, Ye X, Di X, Li D, Zhao H, Zhang B*, Chen G*, Liu H-K*, Qian Y* (2021) In vivo brain imaging of amyloid-b aggregates in Alzheimer's disease with a near-infrared fluorescent probe. ACS Sensors 2021 (6):863-870. 6. Bi H，Zhou C，Zhang Y，Cai X，Ji M，Yang J，Chen G*, Hu Y*. Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and agerelated neurodegeneration in the cortex independent of the Notch signaling. CNS Neuroscience & Therapeutics 2021 (27): 174-185. 7. Zhang T, Ding H, Wang Y, Yuan Z, Zhang Y, Chen G*, Xu Y*, Chen L*. Akt3-mTOR regulates hippocampal neurogenesis in adult mouse. Journal of Neurochemistry 2021:15441. 8. Shao C, Yuan J, Liu Y, Wang X, Gu J, Chen G, Zhang B, Liu H, Zhao J*, Zhu H* and Qian Y*. Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase- mediated oxidative stress and inhibit ferroptosis. Proc. Natl. Acad. Sci. USA 2020 (117): 10155-10164. 9. Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G*, Yin Z* and Hu Y*. Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development (Cover story). Cerebral Cortex 2020 (30):4183-4196. 10. Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G*, Guo Z* and Wang X*. Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease (Cover story). Science China Chemistry 2020 (63):73-82. 11. Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J* and Chen G*. Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. Journal of Neuroscience 2019 (39):2195-2207. 12. Zhang T, Shi Z, Wang Y, Wang L, Zhang B, Chen G, Wan Q, Chen L*. Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR. Acta Physiologica 2019 (225): e13167. 13. Zhou J, Wang X, Zhou L, Zhou L, Xu F, Su L, Wang H, Jia F, Xu F, Chen G, De Zeeuw C and Shen Y. Ablation of TFR1 in Purkinje cells inhibits mGlu1 trafficking and impairs motor coordination, but not autistic-like behaviors. Journal of Neuroscience 2017 (37): 11335- 11352.