个人简介

David completed his degree and PhD at the University of Birmingham before embarking on a research career as a Senior Research and Teaching Fellow. He joined Birmingham City University in 2016 as lead for the Biomedical sciences programme. David maintains research links with the University of Birmingham where he continues to supervise a doctoral research student

研究领域

Microbiology Genetics Molecular Biology Biotechnology

Dr Lee’s research focuses on the regulation of gene expression in bacteria, with particular interest in understanding how the organized bacterial chromosome impacts on, and is impacted by, transcription events. In addition, he is interested in how horizontally acquired genes, particularly transcription factors, impact upon gene expression.

近期论文

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Lambert, C., Cadby, I.T., Till, R., Bui, N.K., Lerner, R., Hughes, W.S., Lee, D.J., Alderwick, L.J., Vollmer, W., Sockett, E.R. & Lovering, A.L. (2015) Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus. Nature Comm, doi: 10.1038/ncomms9884. IF: 11.47 Bryant, J.A., Sellars, L.E., Busby, S.J. & Lee, D.J. (2014). Chromosome position effects on gene expression in Escherichia coli K-12. Nucleic Acids Res 42, 11383-92. IF: 9.11 Bingle, L.E., Constantinidou, C., Shaw, R.K., Islam, M.S., Patel, M., Snyder, L.A., Lee, D.J., Penn, C.W., Busby, S. J. & Pallen, M. J. (2014). Microarray analysis of the Ler regulon in enteropathogenic and enterohaemorrhagic Escherichia coli strains. PLoS One 9, e80160. IF: 3.23 Capeness, M.J., Lambert, C., Lovering, A.L., Till, R., Uchida, K., Chaudhuri, R., Alderwick, L.J., Lee, D.J., Swarbreck, D., Liddell, S., Aizawa, S. & Sockett, R.E. (2013). Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling. PLoS One 8, e79759. IF: 3.23 Lee, D.J., Minchin, S.D. & Busby, S.J. (2012). Activating transcription in bacteria. Annu Rev Microbiol 66, 125-52. IF: 12.18 Lee, D.J. & Busby, S.J. (2012). Repression by cyclic AMP receptor protein at a distance. MBio 3, e00289-12. IF: 6.79 Sanchez-Romero, M.A., Lee, D.J., Sanchez-Moran, E. & Busby, S.J. (2012). Location and dynamics of an active promoter in Escherichia coli K-12. Biochem J 441, 481-5. IF: 4.04 Hollands, K., Lee, D.J., Lloyd, G.S. & Busby, S.J. (2010). Activation of sigma 28-dependent transcription in Escherichia coli by the cyclic AMP receptor protein requires an unusual promoter organization. Mol Microbiol 75, 1098-111. IF: 4.42 Browning, D.F., Lee, D.J., Spiro, S. & Busby, S.J. (2010). Down-regulation of the Escherichia coli K-12 nrf promoter by binding of the NsrR nitric oxide-sensing transcription repressor to an upstream site. J Bacteriol 192, 3824-8. IF: 2.81 Piper, S.E., Mitchell, J.E., Lee, D.J. & Busby, S.J. (2009). A global view of Escherichia coli Rsd protein and its interactions. Mol Biosyst 5, 1943-7. IF: 3.21 Lee, D.J., Bingle, L.E., Heurlier, K., Pallen, M.J., Penn, C.W., Busby, S.J. & Hobman, J.L. (2009). Gene doctoring: a method for recombineering in laboratory and pathogenic Escherichia coli strains. BMC Microbiol 9, 252. IF: 2.73 Grainger, D.C., Lee, D.J. & Busby, S.J. (2009). Direct methods for studying transcription regulatory proteins and RNA polymerase in bacteria. Curr Opin Microbiol 12, 531-5. IF: 5.90 Butala, M., Busby, S.J. & Lee, D.J. (2009). DNA sampling: a method for probing protein binding at specific loci on bacterial chromosomes. Nucleic Acids Res 37, e37. IF: 9.79 Lee, D.J., Busby, S.J., Westblade, L.F. & Chait, B.T. (2008). Affinity isolation and I-DIRT mass spectrometric analysis of the Escherichia coli O157:H7 Sakai RNA polymerase complex. J Bacteriol 190, 1284-9. IF: 2.81 Grainger, D.C., Goldberg, M.D., Lee, D.J. & Busby, S.J. (2008). Selective repression by Fis and H-NS at the Escherichia coli dps promoter. Mol Microbiol 68, 1366-77. IF: 4.42