个人简介

Marcelo Calderón received his Ph.D. in organic chemistry in 2007 from the National University of Córdoba, Argentina, under the supervision of Prof. Miriam Strumia. His research topic dealt with the preparation of amphiphilic polymers by dendronization. In 2007 he joined the Research Group of Prof. Rainer Haag at the Freie Universitat Berlin for his Postdoctoral work, where he pursued the development of polymer-drug conjugates for the passive targeted delivery of drugs, genes, and imaging probes. Since May 2013 he is a Junior Profesor for Macromolecular and Organic Chemistry at the Institute for Chemistry and Biochemistry from the Freie Universität Berlin.

研究领域

Polymer Therapeutics

The research interest of our group deals with the development of novel polymer therapeutic concepts. We use responsive dendritic systems and nanogels as smart polymeric systems for the improvement of the therapeutic index of drugs. Our main areas of research are: (1) multifunctional polymer-drug conjugates, (2) self-assembling amphiphiles for the controlled delivery of bioactives, (3) new diagnostic technologies as theranostic approaches, and (4) enviroment-responsive nanogels. Our work is mainly focused on polymer and organic chemistry that is supported by our strong international collaboration network involving biochemists, biologists, medical doctors, etc. with knowledge in areas as gene therapy, cancer therapeutics, topical applications, amongst others.

近期论文

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"Dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage", H. R. Krüger, G. Nagel, S. Wedepohl, M. Calderón*, Nanoscale (2015), 7, 3838-3844. "Dendritic Amphiphiles as Additives for Honeycomb-like Patterned Surfaces by Breath Figures: Role of the Molecular Characteristics on the Pore Morphology", A.S. de León, S. Malhotra, M. Molina, R. Haag, M. Calderón*, J. Rodriguez-Hernandez, A. Munoz-Bonilla*, Journal of Colloid and Interface Science (2015), 440, 263–271. "Hair Follicles as a Target Structure for Nanoparticles", "J. Lademann, F. Knorr, H. Richter, S. Jung, M.M.C. Meinke, E. Ruehl, U. Alexiev, M. Calderón, A. Patzelt. Journal of Innovative Optical Health Sciences (2015), 8, 1530004. "Nitric Oxide Releasing Nanomaterials for Cancer Treatment: Current Status and Perspectives", A. B. Seabra, R. de Lima, M. Calderón. Current Topics in Medicinal Chemistry (2015), 15, 298-308. "Dendritic Polyglycerol Sulfate as a Novel Platform for Paclitaxel Delivery: Pitfalls of Ester Linkage", A. Sousa-Herves, P. Würfel, N. Wegner, J. Khandare, K. Licha, R. Haag, P. Welker*, and M. Calderón*, Nanoscale (2015), 7, 3923-3932. "Facile ultrasonication approach for the efficient synthesis of ethylene glycol-based thermoresponsive nanogels", C. Biglione, A. Sousa-Herves, M. Menger, S. Wedepohl, M. Calderón*, M.C. Strumia*, RSC Advances (2015), 5, 15407-15413. "Dendritic polymers for smart drug delivery applications", J. Khandare*, M. Calderón*, Nanoscale (2015), 7, 3806-3807. "Thermoresponsive Nanodevices in Biomedical Applications", J. Bergueiro, M. Calderón*, Macromolecular Bioscience (2015), 15, 183-199. "Thermosensitive Dendritic Polyglycerol-Based Nanogels for Cutaneous Delivery of Biomacromolecules", M. Witting§, M. Molina§, K. Obst, H.C. Hennies, M. Calderón, W. Frieß, S. Küchler, Nanomedicine: Nanotechnology, Biology, and Medicine, in press "One-pot synthesis of doxorubicin-loaded multiresponsive nanogels based on hyperbranched polyglycerol", A. Sousa-Herves, S. Wedepohl, M. Calderón*, Chemical Communications (2015), 51, 5264-5267. "First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate", N. Dib, L. Fernández, L. Otero, M. Santo, M. Calderón, M. Martinelli, M. Strumia, Journal of Inclusion Phenomena and Macrocyclic Chemistry (2015), In press. "A selective macromolecular probe for in vivo imaging of cathepsin B activity in the tumor microenvironment", H.-Y. Hu, H.R. Krüger, D. Vats, M. Vizovisek, A. Duro-Castano, D. Bühlmann, J. Rajkovic, S. Reichert, K.U. Wendt, M. Calderón, M. Rudin, M.J. Vicent, O. Plettenburg, B. Turk, C. Schultz, R. Haag. Manuscript submitted. "Self-propelled Carbon Nanotube Based Microrockets for Rapid Capture and Isolation of Circulating Tumor Cells", S.S. Banerjee, M. Calderón, Jayant J. Khandare et al. Manuscript submitted. "Stimuli-responsive nanogel composites for biomedical applications.", M. Molina, M. Asadian-Birjand, J. Balach, J. Bergueiro, M. Calderón*. Manuscript submitted. "New approaches from nanomedicine for treating Leishmaniasis", V. Gutiérrez, A.B. Seabra, R.M. Reguera, J. Khandare, M. Calderón*. Manuscript submitted. "Engineering Thermoresponsive Polyether-Based Dendritic Nanogels for Biomedical Applications", M. Asadian-Birjand, J.C. Cuggino, R.-C. Mutihac, K. Achazi, J. Dernedde, F. Rancan, U. Blume-Peytavi, A. Vogt, M. Calderón*. Manuscript submitted. "Structure-activity Relationship Study of Dendritic Polyglycerolamine for Efficient siRNA Transfection", F. Sheikhi-Mehrabadi, O. Hirsch, R. Zeisig, P. Posocco, E. Laurini, S. Pricl, R. Haag, W. Kemmner, M. Calderon*. Manuscript submitted.