个人简介

Arturo Leone Young Investigator Award, 2012; Cell Biology of Metals Young Investigator Award, 2011; NIH NRSA Post-doctoral Fellowship, 2008-2011; Pegram Award for Excellence in Graduate Research, 2008; Distinction in the Doctoral Dissertation, 2008; Protein Design Symposium Young Investigator Award, 2007; NSF GK-12 Graduate Fellowship, 2005-2007; Miller Award for Outstanding Graduate Teaching, 2005; Distinction in the Chemistry Major, 2003; Finholt Prize in Inorganic Chemistry, 2003; Sigma Xi Grants-In-Aid-of-Research Grant, 2003; Cancer Research Training Award Fellowship, 1999-2001

研究领域

Analytical Chemistry/Biochemistry/Biomolecular Structure and Function/Chemical and Biological Imaging/Chemical Biology/Inorganic Chemistry/Molecular Biophysics

Metalloproteins constitute one of the largest classes of proteins in the proteome and are involved in virtually every metabolic and signaling pathway of consequence to human health and disease. Broadly speaking, the Reddi laboratory is interested in determining the cellular, molecular, and chemical mechanisms by which metalloproteins are activated by cells, and once activated, how they communicate with other biomolecules to promote normal metabolism and physiology, placing an emphasis on systems relevant to cancer, neurodegenerative disorders, and infectious diseases. Current projects in the lab are focused on elucidating heme trafficking pathways and the role of Cu/Zn Superoxide Dismutase (SOD1) in redox signaling. Prospective students will get broad training in disciplines that span modern biochemistry, bioinorganic chemistry, biophysics, chemical biology, molecular genetics, and cell biology.

近期论文

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Cu/Zn Superoxide Dismutase integrates signals from oxygen and glucose to repress respiration. Reddi, A. R., Culotta, V. C. Cell. 2013, 152, 224-235. Analysis of hypoxia and hypoxia-like states through metabolite profiling. Gleason J. E., Corrigan D. J., Cox J. E., Reddi A. R., McGinnis L. A., Culotta V. C. PLoS One. 2011, 6 , e24741. Regulation of manganese antioxidants by nutrient sensing pathways in Saccharomyces cerevisiae. Reddi A. R., Culotta V. C. Genetics. 2011, 189, 1261-70. Probing in vivo Mn2+ speciation and oxidative stress resistance in yeast cells with electron-nuclear double resonance spectroscopy. McNaughton R. L., Reddi A. R., Clement M. H., Sharma A., Barnese K., Rosenfeld L., Gralla E. B., Valentine J. S., Culotta V. C., Hoffman B. M. Proc Natl Acad Sci U S A. 2010, 107, 15335-9. The effect of phosphate accumulation on metal ion homeostasis in Saccharomyces cerevisiae. Rosenfeld L., Reddi A. R., Leung E., Aranda K., Jensen L. T., Culotta V. C. J Biol Inorg Chem. 2010, 15, 1051-62. Manganese homeostasis in Saccharomyces cerevisiae. Reddi A. R., Jensen L. T., Culotta V. C. Chem Rev. 2009, 109, 4722-32. The overlapping roles of manganese and Cu/Zn SOD in oxidative stress protection. Reddi A. R., Jensen L. T., Naranuntarat A., Rosenfeld L., Leung E., Shah R., Culotta V. C. Free Radic Biol Med. 2009, 46, 154-62. Role of protons in the thermodynamic contribution of a Zn(II)-Cys4 site toward metalloprotein stability. Reddi A. R., Gibney B. R. Biochemistry. 2007, 46, 3745-58. Deducing the energetic cost of protein folding in zinc finger proteins using designed metallopeptides. Reddi A. R., Guzman T. R., Breece R. M., Tierney D. L., Gibney B. R. J Am Chem Soc. 2007, 129, 12815-27. Thermodynamic investigation into the mechanisms of proton-coupled electron transfer events in heme protein maquettes. Reddi A. R., Reedy C. J., Mui S., Gibney B. R. Biochemistry. 2007, 46, 291-305. Thermodynamic investigation into the mechanisms of proton-coupled electron transfer events in heme protein maquettes. Reddi A. R., Reedy C. J., Mui S., Gibney B. R. Biochemistry . 2007, 46, 291-305. Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Thompson A. M., Reddi A. R., Shi X., Goldbeck R. A., Moënne-Loccoz P., Gibney B. R., Holman T. R. Biochemistry. 2007, 46, 14629-37. Femtomolar Zn(II) affinity in a peptide-based ligand designed to model thiolate-rich metalloprotein active sites. Petros A. K., Reddi A. R., Kennedy M. L., Hyslop A. G., Gibney B. R. Inorg Chem. 2006, 45, 9941-58. Femtomolar Zn(II) affinity in a peptide-based ligand designed to model thiolate-rich metalloprotein active sites. Petros A. K., Reddi A. R., Kennedy M. L., Hyslop A. G., Gibney B. R. Inorg Chem. 2006, 45, 9941-58. Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteins. Zhuang J., Reddi A. R., Wang Z., Khodaverdian B., Hegg E. L., Gibney B. R. Biochemistry. 2006, 45, 12530-8. Evaluating the roles of the heme a side chains in cytochrome c oxidase using designed heme proteins. Zhuang J., Reddi A. R., Wang Z., Khodaverdian B., Hegg E. L., Gibney B. R. Biochemistry. 2006, 45, 12530-8. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks W. T., Frank D. B., Huff C., Renfrew H. C., Martin J., Meng X., de Caestecker M. P., McNally J. G., Reddi A., Taylor S. I., Roberts A. B., Wang T., Lechleider R. J. J Biol Chem. 2001, 276, 19332-9. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. Parks W. T., Frank D. B., Huff C., Renfrew-Haft C., Martin J., Meng X., de Caestecker M. P., McNally J. G., Reddi A., Taylor S. I., Roberts A. B., Wang T., Lechleider R. J. J Biol Chem. 2001, 276, 19332-9.