熊二虎 - 华南师范大学 - 生命科学学院

个人简介

华南师范大学生命科学学院副研究员，2012年9月-2018年9月在湖南大学生物传感与计量学国家重点实验室/化学化工学院进行硕博连读，获化学专业博士学位。2016年9月-2018年9月在美国德克萨斯大学奥斯汀分校留学。目前主要从事CRISPR基因编辑技术的生物传感研究，纳米生物电化学与电/光电分析化学传感研究，以及核酸分子线路与DNA纳米技术方面的研究。在J. Am. Chem. Soc., ACS Nano, Nano Today, Anal. Chem., Chem. Commun., Biosens. Bioelectron., ACS Sensors等国际期刊发表学术论文近30篇，总引用850余次，单篇引用超过100的2篇，h指数16，i10指数18。主持国家自然科学基金青年基金1项，华南师范大学青年英才科研启动项目1项，湖南省研究生科研创新项目1项，生物传感与计量学国家重点实验室开放课题1项；参与国家重大基础研究培育项目，国家自然科学基金面上项目等多项。

研究领域

目前主要从事CRISPR基因编辑技术的生物传感研究，纳米生物电化学与电/光电分析化学传感研究，以及核酸分子线路与DNA纳米技术方面的研究。

近期论文

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Menglu Hu, Chaoqun Yuan, Tian Tian, Xusheng Wang, Jian Sun, Erhu Xiong,* Xiaoming Zhou,* Single-step, salt-aging-free, and thiol-free freezing construction of AuNP-based bioprobes for advancing CRISPR-based diagnostics, J. Am. Chem. Soc., 2020, 142, 7506–7513. Xusheng Wang, Erhu Xiong,* Tian Tian, Meng Cheng, Wei Lin, Heng Wang, Guihong Zhang, Jian Sun,* Xiaoming Zhou,* Clustered regularly interspaced short palindromic repeats/Cas9-mediated lateral flow nucleic acid assay, ACS Nano, 2020, 14, 2497–2508. Yijuan Bao, Yongzhong Jiang, Erhu Xiong*, Tian Tian, Zhenzhen Zhang, Jing Lv, Yang Li*, Xiaoming Zhou*, CUT-LAMP: Contamination-free loop-mediated isothermal amplification based on the CRISPR/Cas9 cleavage, ACS Sensors, 2020, 5, 1082–1091. Dongbao Yao, Sanchita Bhadra, Erhu Xiong, Haojun Liang, Andrew D. Ellington,* Cheulhee Jung,* Dynamic programming of a DNA walker controlled by protons, ACS Nano, 2020, 14, 4007–4013. Qian Chen, Tian Tian, Erhu Xiong, Po Wang,* Xiaoming Zhou*, CRISPR/Cas13a signal amplification linked immunosorbent assay for femtomolar protein detection, Anal. Chem., 2020, 92, 573–577. Chaoqun Yuan,† Tian Tian,† Jian Sun,† Menglu Hu, Xusheng Wang, Erhu Xiong, Meng Cheng, Yijuan Bao, Wei Lin, Jieming Jiang, Chengwei Yang, Qian Chen, Huang Zhang, Heng Wang, Xiran Wang, Xianbo Deng, Xiaoping Liao, Yahong Liu, Zhang Wang,* Guihong Zhang,* Xiaoming Zhou,* Universal and naked-eye gene detection platform based on the clustered regularly interspaced short palindromic repeats/Cas12a/13a system, Anal. Chem., 2020, 92, 4029–4037. Erhu Xiong, Deshuai Zhen, Ling Jiang,* and Xiaoming Zhou,* Binding-induced 3D-bipedal DNA walker for cascade signal amplification detection of thrombin combined with catalytic hairpin assembly strategy, Anal. Chem., 2019, 91, 15317–15324. Erhu Xiong, Zhenzhen Li, Xiaohua Zhang,* Jiawan Zhou, Xiaoxia Yan, Yunqing Liu, and Jinhua Chen, Triple-helix molecular switch electrochemical ratiometric biosensor for ultrasensitive detection of nucleic acids, Anal. Chem., 2017, 89, 8830–8835. Erhu Xiong, Xiaohua Zhang, Yunqing Liu, Jiawan Zhou, Peng Yu, Xiaoyu Li, and Jinhua Chen,* Ultrasensitive electrochemical detection of nucleic acids based on the dual-signaling electrochemical ratiometric method and exonuclease III-assisted target recycling amplification strategy, Anal. Chem., 2015, 87, 7291–7296. Erhu Xiong, Deshuai Zhen, Ling Jiang,* Homogeneous enzyme-free and entropy-driven isothermal fluorescent assay for nucleic acids based on dual-signal output amplification strategy, Chem. Commun., 2018, 54, 12594–12597. Erhu Xiong, Xiaoxia Yan, Xiaohua Zhang,* Yunqing Liu, Jiawan Zhou, Jinhua Chen,* Exonuclease III–assisted cascade signal amplification strategy for label-free and ultrasensitive electrochemical detection of nucleic acids, Biosens. Bioelectron., 2017, 87, 732–736. Erhu Xiong, Liang Wu, Jiawan Zhou, Peng Yu, Xiaohua Zhang,* Jinhua Chen,* A ratiometric electrochemical biosensor for sensitive detection of Hg2+ based on thymine–Hg2+–thymine structure, Anal. Chim. Acta, 2015, 853, 242–248. Erhu Xiong, Deshuai Zhen, Ling Jiang,* Cascade signal amplified assay of nucleic acids based on entropy-driven amplification strategy and Mg2+-dependent DNAzyme cleavage, Talanta, 2019, 198， 179–184. Erhu Xiong,† Xiaoxia Yan,† Xiaohua Zhang,* Yanmei Li, Ruiying Yang, Leixia Meng, Jinhua Chen,* A new photoelectrochemical biosensor for ultrasensitive determination of nucleic acid based on three-stage cascade signal amplification strategy, Analyst, 2018, 143, 2799–2806. Erhu Xiong, Ling Jiang,* A ultrasensitive electrochemical immunoassay based on proximity hybridization-triggered three-layer cascade signal amplification strategy, Analyst, 2019, 144, 634–640. Erhu Xiong, Xiaohua Zhang,* Yunqing Liu, Jiawan Zhou, Peng Yu, and Jinhua Chen,* An electrochemical biosensor for sensitive detection of Hg2+ based on exonuclease III-assisted target recycling and hybridization chain reaction amplification strategies, Anal. Methods, 2016, 8, 2106–2111. Alexander A. Boulgakov,† Erhu Xiong,† Sanchita Bhadra, Andrew D. Ellington, Edward M. Marcotte,* From space to sequence and back again: iterative DNA proximity ligation and its applications to DNA-based imaging, bioRxiv, 2018, DOI: https://doi.org/10.1101/470211. Liang Wu, Erhu Xiong, Xia Zhang, Xiaohua Zhang, Jinhua Chen,* Nanomaterials as signal amplification elements in DNA-based electrochemical sensing, Nano Today, 2014, 9, 197–211. Liang Wu, Xiaohua Zhang, Wei Liu, Erhu Xiong, Jinhua Chen,* Sensitive electrochemical aptasensor by coupling “signal-on’’ and “signal-off’’ strategies, Anal. Chem., 2013, 85, 8397–8402. Yunqing Liu, Erhu Xiong, Xiaoyu Li, Junjing Li, Xiaohua Zhang,* Jinhua Chen,* Sensitive electrochemical assay of alkaline phosphatase activity based on TdT-mediated hemin/G-quadruplex DNAzyme nanowires for signal amplification, Biosens. Bioelectron., 2017, 87, 970–975.