个人简介
Prof Kenneth Lo obtained his BSc (1993) and PhD (1997) degrees at The University of Hong Kong. His PhD work centered on the design of luminescent transition metal complexes as DNA and metal-ion probes; and the photophysical and photochemical studies of luminescent polynuclear coinage metal chalcogenide complexes. From 1997 to 1999, he worked as a Croucher Foundation Postdoctoral Research Fellow in the research groups of Prof H. Allen O. Hill, FRS and Dr Luet-Lok Wong of the Inorganic Chemistry Laboratory, University of Oxford. He carried out research work on genetic engineering and electrochemistry of cytochrome P450cam and putidaredoxin. Prof Lo joined the Department of Biology and Chemistry (currently Department of Chemistry) of City University of Hong Kong as Assistant Professor in 1999 and became Associate Professor (Scale B) in 2003, Associate Professor (Scale A) in 2007, and Professor in 2011. He is currently the Program Leader of BSc (Hons) Chemistry. At the College level, he is a member of the College Board. At the University level, he is currently on the University Research Committee and a member of the Working Group of Applied R & D.
Prof Lo's research interest is the utilization of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes, with a focus on the development of intracellular sensors, photoactive labels, and bioimaging reagents. He received The APA Prize for Young Scientist from The Asian and Oceanian Photochemistry Association in 2005 and The Distinguished Lectureship Award from The Chemical Society of Japan in 2011. He was awarded a Croucher Senior Research Fellowship from the Croucher Foundation in 2015. He was one of the Chairs of the Gordon Research Conference Metals in Medicine 2018 and is the Chair of the 23rd International Symposium of the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019). He was on the Editorial Advisory Board of Inorganic Chemistry (2015 to 2017) and the Advisory Board of RSC Advances from 2013 to 2015 He served as an Associate Editor for RSC Advances from 2015 to 2020 and has been an Associate Editor for Inorganic Chemistry since 2020.
研究领域
The main theme of our work is the utilization of luminescent transition metal complexes as nonisotopic covalent labels and noncovalent probes for biomolecules.
We have designed strongly luminescent rhenium(I), rhodium(III) and iridium(III) polypyridine complexes with an isothiocyanate, aldehyde, iodoacetamide and maleimide moiety. Amine- and sulfhydryl-modified oligonucleotides, amino acids, peptides and proteins have been labelled with these complexes to yield luminescent bioconjugates. New bioassays for molecular substrates including the drug digoxin have been developed.
Luminescent rhenium(I), ruthenium(II) and iridium(III) polypyridine complexes containing a biotin, indole, estradiol and fatty acid pendant have been designed. All the complexes display increased emission intensities and lifetimes upon binding to their respective biological receptors. We have used a selection of these complexes with intense and long-lived emission as energy donors in FRET-based bioassays. Additionally, systematic variation of the polypyridine ligands results in the production of new luminescent biological crosslinkers. Furthermore, the cytotoxicity and cellular uptake properties of these complexes have been examined.
近期论文
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P. K.-K. Leung, L. C.-C. Lee, H. H.-Y. Yeung, K. W. Io and K. K.-W. Lo, "Bioorthogonal Control of the Phosphorescence and Singlet Oxygen Photosensitisation Properties of Iridium(III) Tetrazine Complexes", Chemical Communications, 2021, in press
K. K.-W. Lo, "Preface: The 23rd International Symposium on the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019)", Coordination Chemistry Reviews, 2021, 434, 213800
A. S.-Y. Law, L. C.-C. Lee, K. K.-W. Lo and V. W.-W. Yam, "Aggregation and Supramolecular Self-Assembly of Low-Energy Red Luminescent Alkynylplatinum(II) Complexes for RNA Detection, Nucleolus Imaging, and RNA Synthesis Inhibitor Screening", Journal of the American Chemical Society, 2021, 143, 5396 – 5405
L. C.-C. Lee, A. W.-Y. Tsang, H.-W. Liu and K. K.-W. Lo, "Photofunctional Cyclometalated Iridium(III) Polypyridine Complexes Bearing a Perfluorobiphenyl Moiety for Bioconjugation, Bioimaging, and Phototherapeutic Applications", Inorganic Chemistry, 2020, 59, 17496 – 14806
P. K.-K.- Leung and K. K.-W. Lo, "Modulation of emission and singlet oxygen photosensitisation in live cells utilising bioorthogonal phosphorogenic probes and protein tag technology", Chemical Communications, 2020, 56, 6074 – 6077
K. K.-W. Lo, "Preface: The 23rd International Symposium on the Photochemistry and Photophysics of Coordination Compounds (ISPPCC 2019)", Journal of Inorganic Biochemistry, 2020, 209, 111128
J. Shum, P.-Z. Zhang, L. C.-C. Lee and K. K.-W. Lo, "Bioorthogonal Phosphorogenic Rhenium(I) Polypyridine Sydnone Complexes for Specific Lysosome Labeling", ChemPlusChem, 2020, 85, 1374 – 1378 Cover Picture for Issue 7/2020
K. K.-W. Lo, "Molecular Design of Bioorthogonal Probes and Imaging Reagents Derived from Photofunctional Transition Metal Complexes", Accounts of Chemical Research, 2020, 53, 32 – 44
A. S.-Y. Law, L. C.-C. Lee, M. C.-L. Yeung, K. K.-W. Lo and V. W.-W. Yam, "Amyloid Protein-Induced Supramolecular Self-Assembly of Water-Soluble Platinum (II) Complexes: A Luminescence Assay for Amyloid Fibrillation Detection and Inhibitor Screening", Journal of the American Chemical Society, 2019, 141, 18570 – 18577
J.-H. Zhu, B. Z. Tang, and K. K.-W. Lo, "Luminescent Molecular Octopuses with a Polyhedral Oligomeric Silsesquioxane Core and Iridium(III) Polypyridine Arms: Synthesis, Aggregation Induced Emission, Cellular Uptake and Bioimaging Studies", Chemistry – A European Journal, 2019, 25, 10633 – 10641
S. P.-Y. Li, V. M.-W. Yim, J. Shum and K. K.-W. Lo, "Iridium(III) Polypyridine Complexes with a Disulfide Linker as Biological Sensors and Cytotoxic Agents", Dalton Transactions, 2019, 48, 9692 – 9702 ( Link ) (under the theme "Diagnostics and Medical Applications" of the themed issue "d-Block Chemistry").
A. M.-H. Yip, J. Shum, H.-W. Liu, H. Zhou, M. Jia, N. Niu, Y. Li, C. Yu and K. K.-W. Lo, "Luminescent Rhenium(I) Polypyridine Complexes Appended with a Perylene Diimide or Benzoperylene Monoimide Moiety: Photophysics, Intracellular Sensing, and Photocytotoxic Activity", Chemistry – A European Journal, 2019, 25, 8970 – 8974
J. Shum, P. K.-K. Leung and K. K.-W. Lo, "Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications", Inorganic Chemistry, 2019, 58, 2231 – 2247
L. C.-C. Lee, H. M.-H. Cheung, H.-W. Liu and K. K.-W. Lo, "Exploitation of Environment-sensitive Luminophores in the Design of Novel Sydnone‐based Bioorthogonal Imaging Reagents", Chemistry – A European Journal, 2018, 24, 14064 – 14068
K. Y. Zhang, P. Gao, G. Sun, T. Zhang, X. Li, S. Liu, Q. Zhao, K. K.-W. Lo, and W. Huang, "Dual-phosphorescent Iridium(III) Complexes Extending Oxygen Sensing from Hypoxia to Hyperoxia", Journal of the American Chemical Society, 2018, 140, 7827 – 7834.
A. M.-H. Yip and K. K.-W. Lo "Luminescent Rhenium(I), Ruthenium(II), and Iridium(III) Polypyridine Complexes Containing a Poly(ethylene glycol) Pendant or Bioorthogonal Reaction Group as Biological Probes and Photocytotoxic Agents", Coordination Chemistry Reviews, 2018, 361, 138 – 163
L. C.-C. Lee, K.-K. Leung and K. K.-W. Lo, "Recent Development of Luminescent Rhenium(I) Tricarbonyl Polypyridine Complexes as Cellular Imaging Reagents, Anticancer Drugs, and Antibacterial Agents", Daltons Transactions, 2017, 46, 16357 – 16380
C. T.-S. Lau, C. Chan, K. Y. Zhang, V. A. L. Roy and K. K.-W. Lo, "Photophysical, Cellular Uptake, and Bioimaging Studies of Luminescent Ruthenium(II) Polypyridine Complexes Containing a D-Fructose Pendant", European Journal of Inorganic Chemistry, 2017, 5288 – 5294 Included in the Cluster Issue entitled "Luminescent Materials: Metal Complexes, Clusters, and Nanomaterials" Guest Editorial
K. K.-S. Tso, H.-W. Liu and K. K.-W. Lo, "Phosphorogenic Sensors for Biothiols Derived from Cyclometalated Iridium(III) Polypyridine Complexes Containing a Dinitrophenyl Ether Moiety", Journal of Inorganic Biochemistry, 2017, 177, 412 – 422
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