个人简介

DARPA Young Faculty Award (2014) DuPont Young Professor for Scientific Innovation Award (2014) Distinction in the doctoral dissertation (2008) Pegram Award for excellence in graduate research (2008) Novartis Fellowship in Organic Chemistry (2004) O.T. and Kathryn Walter Award in Biology (2003) Beltmann Undergraduate Summer Research Fellowship (2002) Howard Hughes Undergraduate Summer Research Fellowship (2001)

研究领域

Analytical Chemistry/Biochemistry/Biofuels and Biomanufacturing/Biomolecular Structure and Function/Chemical Biology/Energy and Sustainability

Professor Peralta-Yahya’s research group is developing foundational technologies to more effectively engineer biological systems for chemical synthesis. One area of research is the development of biosensors to screen chemical-producing microbes, which could identify strains that produce chemicals at industrially relevant yield. This technology has potential applications in the area of microbial synthesis of pharmaceuticals & microbial production of high energy density fuels.

近期论文

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Sarria S., Wong B., Garía Martín H., Keasling J., Peralta-Yahya P. Microbial synthesis of pinene, ACS Synth Biol, 3, 466-75, 2014. de Rond T, Peralta-Yahya P, Cheng X, Northen TR, Keasling JD. Versatile synthesis of probes for high-throughput enzyme activity screening, Anal Bioanal Chem, 405, 4969-73, 2013. Romanini D., Peralta-Yahya P., Mondol V., Cornish V.W. A heritable recombination system for synthetic darwinian evolution in yeast, ACS Synth Biol, 1, 602-9, 2012. Peralta-Yahya P., Zhang F., del Cardayre S.B., Keasling J.D. Microbial engineering for the production of advanced biofuels, Nature, 488, 320-28, 2012. McAndrew R,P., Peralta-Yahya P., DeGiovanni A., Pereira J.H., Hadi M.Z., Keesling J.D., Adams P.D. Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure, 19, 1875-84, 2011. Peralta-Yahya P., Ouellet M., Chan R., Mukhopadhyay A., Keasling J.D., Lee T.S. Identification and microbial production of a terpene-based advanced biofuel, Nat Commun 2:483, doi: 10.1038/ncomms1494, 2011. Bokinsky G., Peralta-Yahya P., George A., Holmes B.M., Steen E.J., Dietrich J., Lee T.S., Tullman-Ercek D., Voigt C.A., Simmons B.A., Keasling J.D Synthesis of three advanced biofuels from ionic liquid-pretreated switchgrass using engineered Escherichia coli, Proc Natl Acad Sci USA. 108, 19949-54, 2011. Pirakitikulr N., Ostrov N., Peralta-Yahya P., Cornish, V.W. PCRless library mutagenesis via oligonucleotide recombination in yeast. Protein Sci, 19, 2336-46, 2010. Peralta-Yahya P., Keasling J.D. Advanced biofuel production in microbes, Biotechnol J, 5, 147-62, 2010. Peralta-Yahya P., Carter B.T., Lin H., Tao H., Cornish V.W. High-throughput selection for cellulase catalysts using chemical complementation, J Am Chem Soc, 130, 17446-52, 2008. Tao H., Peralta-Yahya P., Decatur J., Cornish V.W. Characterization of a new glycosynthase cloned by using chemical complementation, ChemBioChem, 9, 681-4, 2008. H. Tao, P. Peralta-Yahya, H. Lin, V.W. Cornish., Optimized design and synthesis of chemical dimerizer substrates for detection of glycosynthase activity via chemical complementation, Bioorg Med Chem, 14, 6940-53, 2006.