Bleris, Leonidas - The University of Texas at Dallas

个人简介

Leonidas Bleris is a Cecil H. and Ida Green Chair in Systems Biology Science and Professor with the Bioengineering Department of the University of Texas at Dallas. Before joining UTD, Bleris was a Postdoctoral Fellow at the FAS Center for Systems Biology at Harvard University. Bleris earned a Ph.D. in Electrical Engineering from Lehigh University in 2006. He received a Diploma in Electrical and Computer Engineering in 2000 from Aristotle University of Thessaloniki, Greece. Bleris was awarded the Christine Mirzayan Science and Technology Policy Graduate Fellowship from the National Academy of Science (NAS), and served with the Board of Mathematical Sciences and their Applications. During 2009-2010, Bleris was a Visiting Scientist at the FAS Center for Systems Biology at Harvard University, and 2008-2015 an Independent Expert with the European Commission under the "Science, Economy and Society" directorate. Bleris served as the University of Texas at Dallas Representative for the 2011-2012 Tuning Oversight Council for Engineering and Science, Committee on Bioengineering, and received the 2014 Junior Faculty Research Award from the Erik Jonsson School of Engineering and Computer Science. In 2018 Bleris was awarded a Cecil H. and Ida Green Chair in Systems Biology Science. His research has focused on systems biology, mammalian synthetic biology and genome editing, and has received support from the National Institutes of Health (NIH) and the National Science Foundation (NSF) including the NSF CAREER award.

研究领域

CRISPR-based editing reveals edge-specific effects in biological networks. Mapping the operational landscape of microRNAs in synthetic gene circuits. Exploiting the CRISPR/Cas9 PAM constraint for single-nucleotide resolution interventions. Discriminating direct and indirect connectivities in biological networks. CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells. Assembly and validation of versatile transcription activator-like effector libraries. Biological 2-input decoder circuit in human cells. Synthetic mammalian transgene negative autoregulation. Reverse engineering validation using a benchmark synthetic gene circuit in human cells.

近期论文

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Plasmonic LAMP: Improving the Detection Specificity and Sensitivity for SARS-CoV-2 by Plasmonic Sensing of Isothermally Amplified Nucleic Acids. Ye, H., C. Nowak, Y. Liu, Y. Li, T. Zhang, L. Bleris*, Z. Qin*.Small, 2022. Machine learning-based approaches for identifying human blood cells harboring CRISPR-mediated fetal chromatin domain ablations. Li, Y., S. Zaheri, K. Nguyen, F. Hassanipour, L. Bleris.Scientific Reports, 12(1481), 2022. URL Cell Morphology-based Machine Learning Models for Human Cell State Classification. Li, Y., C. Nowak, U. Pham, K. Nguyen, L. Bleris. npj Systems Biology and Applications, 7(23), 2021. Robust filtering and noise suppression in intragenic miRNA-mediated host regulation. Kang, T., T. Quarton, K. Ehrhardt, C. Nowak, A. Singh, Y. Li, L. Bleris. iScience, 23(10), 2020. Transcriptomics and Solid Tumors: The Next Frontier in Precision Cancer Medicine. Tsimberidou, A., Fountzilas, E., Bleris, L. and R. Kurzrock Seminars in Cancer Biology, 2020. URL Uncoupling gene expression noise along the central dogma using genome engineered human cell lines. Quarton, T., Kang, T., Papakis, V., Nguyen, K., Nowak, C., Li, Y. and L. Bleris Nucleic Acids Research, 48(16), 2020. Mechanistic insights into host adaptation, virulence and epidemiology of the phytopathogen Xanthomonas. An, S., Potnis, N., Dow, J., Vorholter, F., He, Y., Becker, A., Teper, D., Li, Y., Wang, N., Bleris, L., Ji-Liang Tang FEMS Microbiology Reviews, 44(1), 2020. URL Coevolutionary couplings unravel PAM proximal constraints of CRISPR-SpCas9. Li, Y., Paz, J., Jiang, X., Liu, R., Pokkulandra, A., Bleris, L.*, F. Morcos* Biophysical Journal, 117(9), 2019. URL p63 and SOX2 dictate glucose reliance and metabolic vulnerabilities in squamous cell carcinoma. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBarardinis RJ, Kim TH, Kim JW. Cell Reports, 28(7), 2019. CRISPR-based editing reveals edge-specific effects in biological networks. Li, Y., Nowak, C., Withers, D., Pertsemlidis, A., L. Bleris The CRISPR Journal, 2018. Regulating the Uptake of Viral Nanoparticles in Macrophage and Cancer Cells by via a pH Switch. Lee, H., Benjamin, C.E., Nowak, C.M., Tuong, L.H., Welch, R.P., Chen, Z., Dharmarwardana, M., Murray, K.W., Bleris, L., D'Arcy, S., Gassensmith, J.J. Molecular Pharmaceutics, 2018. Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor. Dharmarwardana, M., Martins, A.F., Chen, Z., Palacios, P.M., Nowak, C.M., Welch, R.P., Li, S., Luzuriaga, M.A., Bleris, L., Pierce, B.S., Sherry, A.D., Gassensmith, J.J. Molecular Pharmaceutics, 2018. Mapping the operational landscape of microRNAs in synthetic gene circuits. Quarton, T., K. Ehrhardt, J. Lee, S. Kannan, Y. Li, L. Ma, L. Bleris npj Systems Biology and Applications, 2018. Techniques and strategies employing engineered transcription factors. Lawson, S. and L. Bleris Current Opinion in Biomedical Engineering, 4:152-162, 2017. Guide RNA engineering for versatile Cas9 functionality. Nowak, C. S. Lawson, M. Zerez, L. Bleris Nucleic Acids Research, 2016. Exploiting the CRISPR/Cas9 PAM constraint for single-nucleotide resolution interventions Li, Y., Mendiratta, S., Ehrhardt, K., Kashyap, N., White, M. A. and L. Bleris PLoS ONE, 11(1), 2016. MiR-192-mediated positive feedback loop controls the robustness of stress-induced p53 oscillations in breast cancer cells. Moore, R., H. K. Ooi, T. Kang, L. Bleris and L. Ma PLoS Computational Biology, 11(12), 2015. Discriminating direct and indirect connectivities in biological networks. Kang, T., R. Moore, Y. Li, E. Sontag, L. Bleris Proceedings of the National Academy of Sciences (PNAS), 112, 41, 2015. Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting. Ehrhardt, K. Guinn, M., Quarton, T., Zhang, M. Q., L. Bleris Biosensors and Bioelectronics, 2015. URL